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    HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS
    2.
    发明申请
    HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS 审中-公开
    用于ROMP和RCM反应的高活性催化剂选择性

    公开(公告)号：US20140080984A1

    公开(公告)日：2014-03-20

    申请号：US14086339

    申请日：2013-11-21

    申请人： Zheng-Yun James ZHAN

    发明人： Zheng-Yun James ZHAN

    IPC分类号： C08F4/80

    CPC分类号： C08F4/80 ,  B01J31/1805 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  B01J2531/821 ,  C07F15/0046 ,  C08G61/08 ,  C08G2261/418

    摘要： The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts.

    摘要翻译： 本发明涉及一种新型卡宾配体和钌催化剂，其分别对ROMP和RCM反应具有高度活性和选择性。 它公开了不同取代的卡宾配体对相应的卡宾钌络合物的催化活性和稳定性的显着电子和空间效应; 本发明中的一些新型钌络合物可广泛用作催化剂，对ROMP和RCM反应具有高度有效的选择性。 本发明还涉及新的钌催化剂的制备和复分解的用途。 此外，本发明还提供了在新的钌催化剂存在下通过ROMP反应制备各种官能聚合物的有效方法。

    Polyheterocyclic compounds highly potent as HCV inhibitors
    4.
    发明授权
    Polyheterocyclic compounds highly potent as HCV inhibitors 有权
    作为HCV抑制剂高度有效的多杂环化合物

    公开(公告)号：US08653025B2

    公开(公告)日：2014-02-18

    申请号：US13014993

    申请日：2011-01-27

    申请人： Zheng-Yun James Zhan

    发明人： Zheng-Yun James Zhan

    IPC分类号： A61K38/00 ,  A01N37/18 ,  A61P31/12

    CPC分类号： C07K5/12 ,  A61K31/427 ,  A61K38/00 ,  A61K38/12 ,  A61K45/06 ,  C07D491/056 ,  C07D519/00 ,  C07K5/06078 ,  C07K5/0808 ,  C07K5/1016 ,  A61K2300/00

    摘要： The present invention discloses the structure, preparation methods and uses of a series of novel polyheterocyclic based compounds (Ia-Ib and IIa-IIb) that are highly effective for inhibiting hepatitis C virus (HCV): where the structural variables are defined herein. The present invention is also provides a method of treating HCV infection by the polyheterocyclic based HCV inhibitory compounds, compositions and therapeutic methods.

    摘要翻译： 本发明公开了一系列新型多杂环基化合物（Ia-Ib和IIa-IIb）的结构，制备方法和用途，其对于抑制丙型肝炎病毒（HCV）非常有效：其中结构变量在本文中定义。 本发明还提供了一种通过基于多环基的HCV抑制化合物治疗HCV感染的方法，组合物和治疗方法。

    RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS
    6.
    发明申请
    RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS 有权
    可回收的用于金属反应的Rügenium催化剂

    公开(公告)号：US20120016093A1

    公开(公告)日：2012-01-19

    申请号：US13242363

    申请日：2011-09-23

    申请人： Zheng-Yun James ZHAN

    发明人： Zheng-Yun James ZHAN

    IPC分类号： C08F4/80 ,  C07C2/02 ,  C07F15/00

    CPC分类号： B01J31/2265 ,  B01J31/068 ,  B01J31/1666 ,  B01J31/1683 ,  B01J31/2208 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2404 ,  B01J31/403 ,  B01J2231/54 ,  B01J2531/821 ,  B01J2540/34 ,  B01J2540/40 ,  B01J2540/62 ,  C07C315/04 ,  C07C2601/10 ,  C07F15/0046 ,  Y02P20/584 ,  C07C317/14

    摘要： The invention relates to novel carbene ligands and their incorporated monomeric and resin/polymer linked ruthenium catalysts, which are recyclable and highly active for olefin metathesis reactions. It is disclosed that significant electronic effect of different substituted 2-alkoxybenzylidene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes, some of novel ruthenium complexes in the invention can be broadly used as catalysts highly efficient for olefin metathesis reactions, particularly in ring-closing (RCM), ring-opening (ROM), ring-opening metathesis polymerization (ROMP) and cross metathesis (CM) in high yield. The invention also relates to preparation of new ruthenium complexes and the use in metathesis.

    摘要翻译： 本发明涉及新的卡宾配体及其引入的单体和树脂/聚合物连接的钌催化剂，其可再循环并且对于烯烃复分解反应具有高活性。 公开了不同取代的2-烷氧基亚苄基配体对相应的卡宾钌络合物的催化活性和稳定性的显着电子效应，本发明中的一些新型钌络合物可广泛用作对于烯烃复分解反应高效的催化剂，特别是在环 封闭（RCM），开环（ROM），开环易位聚合（ROMP）和交叉复分解（CM）。 本发明还涉及新的钌络合物的制备和复分解的用途。

    RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS
    7.
    发明申请
    RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS 有权
    可回收的用于金属反应的Rügenium催化剂

    公开(公告)号：US20100041844A1

    公开(公告)日：2010-02-18

    申请号：US12604818

    申请日：2009-10-23

    申请人： Zheng-Yun James ZHAN

    发明人： Zheng-Yun James ZHAN

    IPC分类号： C08F4/80 ,  C07F17/02 ,  C07C15/46

    CPC分类号： B01J31/2265 ,  B01J31/068 ,  B01J31/1666 ,  B01J31/1683 ,  B01J31/2208 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2404 ,  B01J31/403 ,  B01J2231/54 ,  B01J2531/821 ,  B01J2540/34 ,  B01J2540/40 ,  B01J2540/62 ,  C07C315/04 ,  C07C2601/10 ,  C07F15/0046 ,  Y02P20/584 ,  C07C317/14

    摘要： The invention relates to novel carbene ligands and their incorporated monomeric and resin/polymer linked ruthenium catalysts, which are recyclable and highly active for olefin metathesis reactions. It is disclosed that significant electronic effect of different substituted 2-alkoxybenzylidene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes, some of novel ruthenium complexes in the invention can be broadly used as catalysts highly efficient for olefin metathesis reactions, particularly in ring-closing (RCM), ring-opening (ROM), ring-opening metathesis polymerization (ROMP) and cross metathesis (CM) in high yield. The invention also relates to preparation of new ruthenium complexes and the use in metathesis.

    摘要翻译： 本发明涉及新的卡宾配体及其引入的单体和树脂/聚合物连接的钌催化剂，其可再循环并且对于烯烃复分解反应具有高活性。 公开了不同取代的2-烷氧基亚苄基配体对相应的卡宾钌络合物的催化活性和稳定性的显着电子效应，本发明中的一些新型钌络合物可广泛用作对于烯烃复分解反应高效的催化剂，特别是在环 封闭（RCM），开环（ROM），开环易位聚合（ROMP）和交叉复分解（CM）。 本发明还涉及新的钌络合物的制备和复分解的用途。

    Recyclable ruthenium catalysts for metathesis reactions
    10.
    发明授权
    Recyclable ruthenium catalysts for metathesis reactions 有权
    用于复分解反应的可回收钌催化剂

    公开(公告)号：US08049025B2

    公开(公告)日：2011-11-01

    申请号：US12604818

    申请日：2009-10-23

    申请人： Zheng-Yun James Zhan

    发明人： Zheng-Yun James Zhan

    IPC分类号： C07F15/00 ,  C07C2/02

    CPC分类号： B01J31/2265 ,  B01J31/068 ,  B01J31/1666 ,  B01J31/1683 ,  B01J31/2208 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2404 ,  B01J31/403 ,  B01J2231/54 ,  B01J2531/821 ,  B01J2540/34 ,  B01J2540/40 ,  B01J2540/62 ,  C07C315/04 ,  C07C2601/10 ,  C07F15/0046 ,  Y02P20/584 ,  C07C317/14

    摘要： The invention relates to novel carbene ligands and their incorporated monomeric and resin/polymer linked ruthenium catalysts, which are recyclable and highly active for olefin metathesis reactions. It is disclosed that significant electronic effect of different substituted 2-alkoxybenzylidene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes, some of novel ruthenium complexes in the invention can be broadly used as catalysts highly efficient for olefin metathesis reactions, particularly in ring-closing (RCM), ring-opening (ROM), ring-opening metathesis polymerization (ROMP) and cross metathesis (CM) in high yield. The invention also relates to preparation of new ruthenium complexes and the use in metathesis.

    摘要翻译： 本发明涉及新的卡宾配体及其引入的单体和树脂/聚合物连接的钌催化剂，其可再循环并且对于烯烃复分解反应具有高活性。 公开了不同取代的2-烷氧基亚苄基配体对相应的卡宾钌络合物的催化活性和稳定性的显着电子效应，本发明中的一些新型钌络合物可广泛用作对于烯烃复分解反应高效的催化剂，特别是在环 封闭（RCM），开环（ROM），开环易位聚合（ROMP）和交叉复分解（CM）。 本发明还涉及新的钌络合物的制备和复分解的用途。