-
公开(公告)号：US08431565B2
公开(公告)日：2013-04-30
申请号：US12337683
申请日：2008-12-18
Applicant: R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
Inventor： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Robert Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin , Mary-Margaret E. Zablocki
IPC: A61K31/519 , C07D487/04 , A61P25/02
CPC classification number: C07D487/04
Abstract: The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
Abstract translation: 本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗 的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。
-
公开(公告)号：US20130012448A1
公开(公告)日：2013-01-10
申请号：US13543022
申请日：2012-07-06
Applicant: Claudio D. Schteingart , Frédérique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
Inventor： Claudio D. Schteingart , Frédérique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
CPC classification number: C07K5/1016 , A61K38/00 , A61K38/07 , C07K5/10 , C07K5/1008 , C07K5/101 , C07K7/02
Abstract: The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure of formula I: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.
-
公开(公告)号：US20120015930A1
公开(公告)日：2012-01-19
申请号：US13126201
申请日：2009-12-01
Applicant: Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
Inventor： Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
IPC: A61K31/553 , A61K31/55 , C07D498/04 , A61K31/4985 , A61P25/04 , C07D471/04 , A61K31/437 , A61K31/5383 , A61P29/00 , A61P17/04 , C07D487/04 , A61K31/551
CPC classification number: C07D487/04 , A61K31/553 , C07D498/04
Abstract: The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
Abstract translation: 本发明提供了具有通式I的通式结构的取代的咪唑并杂环：其中Y选自-O - ， - OCRgRh - ， - CRgRhO-，-CRgRh-， - （CRgRh）2 - ， - NR1 - ，CRRRNRi-和 -NRiCRgRh-。 还提供了式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂并用于预防和治疗大麻素受体相关疾病和病症，例如疼痛， 炎症和瘙痒。
-
公开(公告)号：US20110275609A1
公开(公告)日：2011-11-10
申请号：US13126490
申请日：2010-01-14
Applicant: Robert Zhiyong Luo
Inventor： Robert Zhiyong Luo
IPC: A61K31/4162 , C07D471/04 , C07D491/113 , C07D487/04 , A61P17/04 , A61K31/437 , A61K31/55 , A61K31/506 , A61K31/541 , A61P29/00 , C07D491/04 , A61K31/496
CPC classification number: A61K31/437 , C07D231/56 , C07D401/04 , C07D403/04 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/10
Abstract: The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I The structures of rings A and B and substituents Ra, Rb and Rc are described in the specification. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis, treatment and inhibition of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
Abstract translation: 本发明提供具有通式I的通式结构的取代的吡唑并 - 杂环环A和B以及取代基R a，R b和R c的结构在说明书中描述。 还提供了式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和用于预防，治疗和抑制大麻素受体相关疾病和病症，例如 疼痛，炎症和瘙痒。
-
公开(公告)号：US07741350B1
公开(公告)日：2010-06-22
申请号：US12582417
申请日：2009-10-20
Applicant: Robert Zhiyong Luo
Inventor： Robert Zhiyong Luo
IPC: A61K31/425 , A61K31/42 , A61K31/415 , A61K31/40 , A61K31/35 , C07D277/00 , C07D413/12 , C07D487/04 , C07D207/06 , C07D311/94
CPC classification number: C07D471/04 , C07D231/56 , C07D401/04 , C07D413/12 , C07D417/04 , C07D491/052
Abstract: The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
Abstract translation: 本发明提供了具有式I的通式结构的取代的吡唑并 - 杂环。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂化物和立体异构体。该化合物可用作大麻素受体的调节剂和预防 以及治疗大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。
-
Patent Agency Ranking
6.发明授权Fluorous tagging compounds and methods of increasing the fluorous nature of compounds 有权氟标记化合物和增加化合物的氟性质的方法公开(公告)号：US07700794B2
公开(公告)日：2010-04-20
申请号：US10999698
申请日：2004-11-29
Applicant: Dennis P. Curran , Roger Read , Zhiyong Luo
Inventor： Dennis P. Curran , Roger Read , Zhiyong Luo
CPC classification number: C07D213/40 , C07C69/96 , C07C237/22 , C07C237/42 , C07C255/62 , C07D207/14 , C07D207/16 , C07D211/62 , C07D217/06 , C07D401/06 , C07D405/06 , Y10T436/13 , Y10T436/19
Abstract: A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group, Rs is a spacer group, d is 1 or 0, m is 1, 2 or 3, Ra is an alkyl group and X is a suitable leaving group. A compound has the formula: wherein Rf is a fluorous group, n is an integer between 0 and 6, m is 1, 2 or 3, Ra is an alkyl group and X is a leaving group.
Abstract translation: 增加化合物的氟性质的方法包括使化合物与至少一种具有下式的第二化合物反应的步骤：其中Rf是氟基，Rs是间隔基，d是1或0，m是1， 2或3，Ra是烷基，X是合适的离去基团。 化合物具有下式：其中Rf是氟基，n是0和6之间的整数，m是1,2或3，Ra是烷基，X是离去基团。
-
公开(公告)号：US20090075907A1
公开(公告)日：2009-03-19
申请号：US12176279
申请日：2008-07-18
Applicant: Claudio D. Schteingart , Frederique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
Inventor： Claudio D. Schteingart , Frederique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
CPC classification number: C07K5/1016 , A61K38/00 , A61K38/07 , C07K5/10 , C07K5/1008 , C07K5/101 , C07K7/02
Abstract: The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure of formula I: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.
Abstract translation: 本发明涉及κ阿片样物质受体的合成肽酰胺配体，特别是涉及低P450 CYP抑制和低渗透入脑的κ阿片受体激动剂。 本发明的合成肽酰胺符合式I的结构：含有这些化合物的药物组合物可用于预防和治疗与多种疾病和病症相关的疼痛和炎症。 这种可治疗的疼痛包括内脏痛，神经性疼痛和痛觉过敏。 与IBD和IBS等条件相关的炎症，眼部和耳部炎症，其他疾病和病症如瘙痒症，水肿，低钠血症，低钾血症，肠梗阻，肠炎和青光眼均可用本发明的药物组合物治疗或预防。
-
公开(公告)号：US20080318935A1
公开(公告)日：2008-12-25
申请号：US12142846
申请日：2008-06-20
Applicant: R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
Inventor： R. Paul Beckett , Richard Foster , Christelle Henault , Janet L. Ralbovsky , Carla M. Gauss , Gary R. Gustafson , Zhiyong Luo , Ann-Marie Campbell , Tatiana E. Shelekhin
IPC: A61K31/5517 , C07D487/04 , C07D471/04 , A61K31/4985 , A61K31/5377 , A61P29/00
CPC classification number: C07D487/04
Abstract: The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
Abstract translation: 本发明提供了具有式I结构的取代的咪唑并杂环化合物。还提供式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂和预防和治疗 的大麻素受体相关疾病和病症，如疼痛，炎症和瘙痒。
-
公开(公告)号：US08951970B2
公开(公告)日：2015-02-10
申请号：US13543022
申请日：2012-07-06
Applicant: Claudio D. Schteingart , Frédérique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
Inventor： Claudio D. Schteingart , Frédérique Menzaghi , Guangcheng Jiang , Roberta Vezza Alexander , Javier Sueiras-Diaz , Robert H. Spencer , Derek T. Chalmers , Zhiyong Luo
CPC classification number: C07K5/1016 , A61K38/00 , A61K38/07 , C07K5/10 , C07K5/1008 , C07K5/101 , C07K7/02
Abstract: The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure of formula I: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.
Abstract translation: 本发明涉及κ阿片样物质受体的合成肽酰胺配体，特别是涉及低P450 CYP抑制和低渗透入脑的κ阿片受体激动剂。 本发明的合成肽酰胺符合式I的结构：含有这些化合物的药物组合物可用于预防和治疗与多种疾病和病症相关的疼痛和炎症。 这种可治疗的疼痛包括内脏痛，神经性疼痛和痛觉过敏。 与IBD和IBS等条件相关的炎症，眼部和耳部炎症，其他疾病和病症如瘙痒症，水肿，低钠血症，低钾血症，肠梗阻，肠炎和青光眼均可用本发明的药物组合物治疗或预防。
-
公开(公告)号：US08835422B2
公开(公告)日：2014-09-16
申请号：US13126201
申请日：2009-12-01
Applicant: Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
Inventor： Stephen J. O'Connor , Jason S. Newcom , Janet L. Ralbovsky , Gary R. Gustafson , R. Paul Beckett , Robert Zhiyong Luo
IPC: A61K31/553 , C07D498/04 , C07D487/04
CPC classification number: C07D487/04 , A61K31/553 , C07D498/04
Abstract: The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCRgRh—, —CRgRhO—, —CRgRh—, —(CRgRh)2—, —NRi—, —CRgRhNRi— and —NRiCRgRh—. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
Abstract translation: 本发明提供了具有通式I的通式结构的取代的咪唑并杂环：其中Y选自-O - ， - OCRgRh - ， - CRgRhO-，-CRgRh-， - （CRgRh）2 - ， - NR1 - ，CRRRNRi-和 -NRiCRgRh-。 还提供了式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂合物和立体异构体。该化合物可用作大麻素受体的调节剂并用于预防和治疗大麻素受体相关疾病和病症，例如疼痛， 炎症和瘙痒。
-
-
-
-
-
-
-
-
-
Search Results
49
records
(took 0.038 seconds)
