摘要:
The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要:
A client device for use in a system having a server, the client device including: a receiving device configured to receive information material from the server, the information material containing a reversible modification providing a visually perceptible disturbing effect having been applied to the information material by using an invertible algorithm which uses values generated from one or more keys, and to receive identifying information that distinguishes the information material from other information material available from the server and condition information which defines a predetermined condition that should be met in order for the reversible modification to be reversed.
摘要:
The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要:
An audio and/or video generation apparatus comprises a recording processor which is operable to record audio and/or video signals on a recording medium, a meta data generation processor which is operable to generate meta data identifying the content of the audio/video signals, and a communications processor which arranged to communicate the meta data separately from the recording medium. Furthermore, the meta data generation processor may be operable to generate at least one sample image which is representative of a video image from the recorded video signals, and to associate the sample image with an address on the recording medium at which the video image is recorded. The video and/or audio generation apparatus provides an advantage in generating and utilising meta data to facilitate the generation of audio/video productions. Accordingly, a system for generating an audio and/or video production comprises an acquisition processor operable in use to receive instructions from a user which instructions are representative of a list of content items for the audio and/or video production. The audio and/or video generation apparatus is arranged in use to receive information representative of the list of content items, and to generate audio and/or video signals in accordance with the content items on the list. An ingestion processor may be provided to receive the list of content items, and the audio and/or video signals and to form the audio and/or video production by associating the audio and/or video signals with the list of content items.
摘要:
A laser system which generates short duration pulses, such as under five nanoseconds at an energy level of up to a few milli-Joules per pulse (mJ/p) with near diffraction limited beam quality. A laser crystal is pumped (excited) by diode lasers. A resonator having at least two mirror surfaces defines a beam path passing through the laser crystal. The beam path in the resonator is periodically blocked by a first optical shutter permitting pump energy to build up in the laser crystal, except for a short period near the end of each pumping period. While the first optical shutter is open a second optical shutter blocks the light in the resonator except for periodic short intervals, the intervals being spaced such that at least one light pulse traveling at the speed of light in the resonator is able to make a plurality of transits through the resonator, increasing in intensity by extracting energy from the excited laser crystal on each transit. After the light pulse has built up in intensity, an optical release mechanism releases the pulse from resonator.
摘要:
A water dispersible powder composition is provided. The powder composition contains at least one film-forming polymer having at least one functional group and at least one reactive component that reacts to form a non-ionic bond with the polymer functional group following dispersion of the powder composition in water. The reaction between the polymer particles in the admixture and the reactive component renders the resulting coating water-resistant. The powder composition of this invention is useful for producing water-resistant coatings.
摘要:
The present invention provides a method of prophylaxis, treatment or inhibition of a cannabinoid receptor-associated disease, disorder or condition in a mammalian subject, the method comprising administering to the subject a compound having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate or stereoisomer thereof, wherein the cannabinoid receptor-associated disease, disorder or condition is pain or an inflammatory disease, disorder or condition, and wherein formula I is as follows: wherein Rb, Rc, Z, Y and m are defined in the specification.
摘要:
The present invention provides methods of prevention and treatment of cannabinoid receptor-associated diseases and conditions, wherein the method includes administering a substituted imidazoheterocyclic compounds having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate, solvate or stereoisomer of a compound having the structure of formula I. The cannabinoid receptor-associated diseases and conditions preventable or treatable by the methods of the present invention include pain, inflammation and pruritis.
摘要:
A client device for use in a system having a server, the client device including: a receiving device configured to receive information material from the server, the information material containing a reversible modification providing a perceptible disturbing effect to the information material, and to receive identifying information that distinguishes the information material from other information material available from the server and condition information which defines a predetermined condition that should be met in order for the reversible modification to be reversed; a transmission device which, in response to a user input providing enabling data which satisfies the predetermined condition, configured to transmit the identifying information and the enabling data to the server, wherein in response to the transmission of the enabling data and the identifying information, the receiving device is configured to receive a key and removing data defining an algorithm for removing the perceptible effect, the removing data being useable by a reversing device to reverse the perceptible effect; and a storage device configured to store the information material that has had the perceptible effect reversed.