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公开(公告)号:US12241060B2
公开(公告)日:2025-03-04
申请号:US18178367
申请日:2023-03-03
Applicant: 10x Genomics, Inc.
Inventor: Hanyoup Kim , David Sukovich , Layla Katiraee , Augusto Manuel Tentori
IPC: C12Q1/6804 , C12N15/10
Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.
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公开(公告)号:US20240301489A1
公开(公告)日:2024-09-12
申请号:US18605260
申请日:2024-03-14
Applicant: 10x Genomics, Inc.
Inventor: Jennifer Chew , Joseph Francis Shuga , Patrick Roelli , Denise Cheung , Alexander Hermes , Yifeng Yin , Naishitha Anaparthy , Ryo Hatori , Marlon Stoeckius , Rapolas Spalinskas , Anna-Maria Katsori , Cedric Uytingco , Mesruh Turkekul , David Sukovich , Christina Galonska , Aleksandra Jurek , Octavian Marian Bloju
IPC: C12Q1/6874 , C12N15/10 , C12Q1/6837
CPC classification number: C12Q1/6874 , C12N15/1065 , C12Q1/6837
Abstract: Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.
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3.
公开(公告)号:US20230416808A1
公开(公告)日:2023-12-28
申请号:US18243582
申请日:2023-09-07
Applicant: 10x Genomics, Inc.
Inventor: David Sukovich , Felice Alessio Bava , Augusto Manuel Tentori , Hanyoup Kim , Amanda Janesick
IPC: C12Q1/6841
CPC classification number: C12Q1/6841
Abstract: Provided herein are methods, compositions, and systems for improved in situ detection of analytes and spatial analysis using, e.g., a sequencing readout.
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4.
公开(公告)号:US20230295699A1
公开(公告)日:2023-09-21
申请号:US18311605
申请日:2023-05-03
Applicant: 10x Genomics, Inc.
Inventor: David Sukovich , Hanyoup Kim , Jerald Sapida , Spontaneous Rose McKnight Russell , Layla Katiraee , Augusto Manuel Tentori
IPC: C12Q1/6841 , C12N15/10
CPC classification number: C12Q1/6841 , C12N15/1065
Abstract: Provided herein are methods of enhancing spatial resolution of an analyte using sandwich maker system. The methods and systems used herein include a first substrate that includes a plurality of probes that include a capture domain and a spatial domain and a second substrate that includes a plurality of probes comprising a capture domain and a spatial domain.
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公开(公告)号:US12195790B2
公开(公告)日:2025-01-14
申请号:US18243582
申请日:2023-09-07
Applicant: 10x Genomics, Inc.
Inventor: David Sukovich , Felice Alessio Bava , Augusto Manuel Tentori , Hanyoup Kim , Amanda Janesick
IPC: C12Q1/68 , C12Q1/6841
Abstract: Provided herein are methods, compositions, and systems for improved in situ detection of analytes and spatial analysis using, e.g., a sequencing readout.
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6.
公开(公告)号:US20240417784A1
公开(公告)日:2024-12-19
申请号:US18815241
申请日:2024-08-26
Applicant: 10x Genomics, Inc.
Inventor: David Sukovich , Hanyoup Kim , Jerald Sapida , Spontaneous Rose McKnight Russell , Layla Katiraee , Augusto Manuel Tentori
IPC: C12Q1/6841 , C12N15/10
Abstract: Provided herein are methods of enhancing spatial resolution of an analyte using sandwich maker system. The methods and systems used herein include a first substrate that includes a plurality of probes that include a capture domain and a spatial domain and a second substrate that includes a plurality of probes comprising a capture domain and a spatial domain.
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7.
公开(公告)号:US12071655B2
公开(公告)日:2024-08-27
申请号:US18311605
申请日:2023-05-03
Applicant: 10x Genomics, Inc.
Inventor: David Sukovich , Hanyoup Kim , Jerald Sapida , Spontaneous Rose McKnight Russell , Layla Katiraee , Augusto Manuel Tentori
IPC: C12Q1/6841 , C12N15/10
CPC classification number: C12Q1/6841 , C12N15/1065
Abstract: Provided herein are methods of enhancing spatial resolution of an analyte using sandwich maker system. The methods and systems used herein include a first substrate that includes a plurality of probes that include a capture domain and a spatial domain and a second substrate that includes a plurality of probes comprising a capture domain and a spatial domain.
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8.
公开(公告)号:US20240218427A1
公开(公告)日:2024-07-04
申请号:US18399109
申请日:2023-12-28
Applicant: 10x Genomics, Inc.
Inventor: David Sukovich , Hardeep Pal Singh , Lauren Gutgesell , Ace George Santiago , Benton Veire , Anuj Patel
IPC: C12Q1/6823 , G01N33/58 , G01N33/68
CPC classification number: C12Q1/6823 , G01N33/58 , G01N33/6857 , G01N2458/10
Abstract: Provided herein are methods for spatial analysis of proteins and/or nucleic acids by capturing a capture handle sequence and/or a connected probe to a capture domain of a capture probe on a spatial array. In some instances, a reagent medium including a monovalent or divalent salt, ethylene carbonate, and/or glycerol is used in the disclosed methods.
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公开(公告)号:US20230203478A1
公开(公告)日:2023-06-29
申请号:US18178367
申请日:2023-03-03
Applicant: 10x Genomics, Inc.
Inventor: Hanyoup Kim , David Sukovich , Layla Katiraee , Augusto Manuel Tentori
IPC: C12N15/10
CPC classification number: C12N15/1065
Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.
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10.
公开(公告)号:US11680260B2
公开(公告)日:2023-06-20
申请号:US17976422
申请日:2022-10-28
Applicant: 10x Genomics, Inc.
Inventor: Hanyoup Kim , David Sukovich , Layla Katiraee , Augusto Manuel Tentori , Lauren Gutgesell , Janine Hensel , Seayar Mohabbat
IPC: C12Q1/6837 , C12N15/10
CPC classification number: C12N15/1065
Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.
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