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1.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20150183775A1
公开(公告)日：2015-07-02
申请号：US14582144
申请日：2014-12-23
申请人： AbbVie Inc.
发明人： Milan BRUNCKO , Yujia DAI , Hong DING , George A. DOHERTY , Steven W. ELMORE , Lisa HASVOLD , Laura HEXAMER , Aaron R. KUNZER , Robert A. MANTEI , Chang H. PARK , Cheol-Min PARK , Andrew M. PETROS , Xiaohong SONG , Andrew J. SOUERS , Gerard M. SULLIVAN , Zhi-Fu TAO , Gary T. WANG , Le WANG , Xilu WANG , Michael D. WENDT , William J. MCCLELLAN
IPC分类号： C07D417/12 , C07D405/12 , C07D413/12 , C07D401/12
CPC分类号： C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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2.发明申请公开(公告)号：US20200345717A1
公开(公告)日：2020-11-05
申请号：US16719794
申请日：2019-12-18
申请人： AbbVie Inc.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , C07D471/04 , A61K31/5377 , A61K45/06 , C07D417/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20220378935A1
公开(公告)日：2022-12-01
申请号：US17661450
申请日：2022-04-29
申请人： AbbVie Inc.
发明人： Andrew C. PHILLIPS , Regina M. REILLY , George A. DOHERTY , Cheng JI , Milan BRUNCKO , Erwin R. BOGHAERT , Mark ANDERSON
IPC分类号： A61K47/68 , C07K16/28 , A61P35/00 , C07K5/068 , C07D491/22
摘要： The present disclosure provides c-Met antibody drug conjugates (ADCs), including compositions and methods of using such ADCs.
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公开(公告)号：US20210346369A1
公开(公告)日：2021-11-11
申请号：US17108719
申请日：2020-12-01
申请人： AbbVie Inc.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , C07D471/04 , A61K31/5377 , A61K45/06 , C07D417/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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5.发明申请BCL-2 SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 有权BCL-2治疗癌症和免疫疾病的选择性病毒诱导剂公开(公告)号：US20130296295A1
公开(公告)日：2013-11-07
申请号：US13839060
申请日：2013-03-15
申请人： ABBVIE INC.
发明人： Milan BRUNCKO , Hong DING , George A. DOHERTY , Steven W. ELMORE , Lisa HASVOLD , Laura HEXAMER , Aaron R. KUNZER , Robert A. MANTEI , William J. MCCLELLAN , Chang H. PARK , Cheol-Min PARK , Andrew M. PETROS , Xiahong SONG , Andrew J. SOUERS , Gerard M. SULLIVAN , Zhi-Fu TAO , Gary T. WANG , Le WANG , Xilu WANG , Michael D. WENDT , Todd M. HANSEN
IPC分类号： A61K31/496 , C07D295/13 , A61K45/06 , C07D401/12 , C07D405/12 , C07D487/04 , C07D309/08 , A61K31/5377
CPC分类号： C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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6.发明公开公开(公告)号：US20240285611A1
公开(公告)日：2024-08-29
申请号：US18450394
申请日：2023-08-15
申请人： ABBVIE INC.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
CPC分类号： A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20220315555A1
公开(公告)日：2022-10-06
申请号：US17518249
申请日：2021-11-03
发明人： Milan BRUNCKO , Hong DING , George A. DOHERTY , Steven W. ELMORE , Lisa A. HASVOLD , Laura HEXAMER , Aaron R. KUNZER , Xiaohong SONG , Andrew J. SOUERS , Gerard M. SULLIVAN , Zhi-Fu TAO , Gary T. WANG , Le WANG , Xilu WANG , Michael D. WENDT , Robert MANTEI , Todd M. HANSEN
IPC分类号： C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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8.发明申请公开(公告)号：US20180221363A1
公开(公告)日：2018-08-09
申请号：US15845835
申请日：2017-12-18
申请人： AbbVie Inc.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , C07D417/14 , C07D471/04 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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