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公开(公告)号：US20150275246A1
公开(公告)日：2015-10-01
申请号：US14735303
申请日：2015-06-10
Applicant: AJINOMOTO CO., INC.
Inventor： Miku Toyazaki , Keiko Noguchi , Mika Moriya , Yuri Uehara
IPC: C12P13/08
Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
Abstract translation: 提供了L-氨基酸的制造方法。 通过培养在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌，其被修饰以使acpP-fabF操纵子减弱，产生L-氨基酸， 来自培养基的氨基酸或细菌的细胞。
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Patent Agency Ranking
2.发明授权Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase 有权使用肠杆菌科的细菌生产L-氨基酸的方法，其具有减毒的编码肽酶的基因的表达公开(公告)号：US08722370B2
公开(公告)日：2014-05-13
申请号：US13687541
申请日：2012-11-28
Applicant: AJINOMOTO CO., INC.
Inventor： Dmitriy Vladimirovich Filippov , Tatyana Viktorovna Leonova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Mika Moriya , Yuri Nagai , Keiko Noguchi
IPC: C12P13/10
CPC classification number: C12P13/10 , C12N1/20 , C12N9/485 , C12P13/08 , C12Y304/11006 , C12Y304/1101 , C12Y304/1302
Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的L-精氨酸，L-瓜氨酸和L-赖氨酸等L-氨基酸的制造方法， 被修饰以减弱一个或多个基因的表达，例如pepA，pepB和pepD基因。
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公开(公告)号：US09487806B2
公开(公告)日：2016-11-08
申请号：US14735303
申请日：2015-06-10
Applicant: AJINOMOTO CO., INC.
Inventor： Miku Toyazaki , Keiko Noguchi , Mika Moriya , Yuri Uehara
Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
Abstract translation: 提供了L-氨基酸的制造方法。 通过培养在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌，其被修饰以使acpP-fabF操纵子减弱，产生L-氨基酸， 来自培养基的氨基酸或细菌的细胞。
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公开(公告)号：US11680279B2
公开(公告)日：2023-06-20
申请号：US16200011
申请日：2018-11-26
Applicant: AJINOMOTO CO., INC.
Inventor： Benjamin Mijts , Christine Roche , Rekha Murali , Sayaka Asari , Keita Fukui , Miku Toyazaki , Keiko Noguchi
IPC: C12P13/12 , C12P7/24 , C12N9/10 , C12N9/06 , C12P7/42 , C12N1/20 , C12R1/15 , C12R1/19 , C12R1/46
CPC classification number: C12P7/24 , C12N1/205 , C12N9/0012 , C12N9/1014 , C12N9/1085 , C12P7/42 , C12P13/12 , C12R2001/15 , C12R2001/19 , C12R2001/46 , C12Y105/0102 , C12Y201/02002 , C12Y205/01006
Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.
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公开(公告)号：US20190161776A1
公开(公告)日：2019-05-30
申请号：US16200011
申请日：2018-11-26
Applicant: AJINOMOTO CO., INC.
Inventor： Benjamin Mijts , Christine Roche , Rekha Murali , Sayaka Asari , Keita Fukui , Miku Toyazaki , Keiko Noguchi
Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.
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6.发明申请Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family, Having Attenuated Expression of Gene(s) Encoding Peptidase 有权使用肠杆菌科的细菌产生L-氨基酸的方法，其具有编码肽酶的基因的减弱表达公开(公告)号：US20130078682A1
公开(公告)日：2013-03-28
申请号：US13687541
申请日：2012-11-28
Applicant: AJINOMOTO CO., INC.
Inventor： Dmitriy Vladimirovich Filippov , Tatyana Viktorovna Leonova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Mika Moriya , Yuri Nagai , Keiko Noguchi
CPC classification number: C12P13/10 , C12N1/20 , C12N9/485 , C12P13/08 , C12Y304/11006 , C12Y304/1101 , C12Y304/1302
Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的L-精氨酸，L-瓜氨酸和L-赖氨酸等L-氨基酸的制造方法， 被修饰以减弱一个或多个基因的表达，例如pepA，pepB和pepD基因。
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