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公开(公告)号：US20150275246A1
公开(公告)日：2015-10-01
申请号：US14735303
申请日：2015-06-10
Applicant: AJINOMOTO CO., INC.
Inventor： Miku Toyazaki , Keiko Noguchi , Mika Moriya , Yuri Uehara
IPC: C12P13/08
Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
Abstract translation: 提供了L-氨基酸的制造方法。 通过培养在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌，其被修饰以使acpP-fabF操纵子减弱，产生L-氨基酸， 来自培养基的氨基酸或细菌的细胞。
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2.发明授权Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase 有权使用肠杆菌科的细菌生产L-氨基酸的方法，其具有减毒的编码肽酶的基因的表达公开(公告)号：US08722370B2
公开(公告)日：2014-05-13
申请号：US13687541
申请日：2012-11-28
Applicant: AJINOMOTO CO., INC.
Inventor： Dmitriy Vladimirovich Filippov , Tatyana Viktorovna Leonova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Mika Moriya , Yuri Nagai , Keiko Noguchi
IPC: C12P13/10
CPC classification number: C12P13/10 , C12N1/20 , C12N9/485 , C12P13/08 , C12Y304/11006 , C12Y304/1101 , C12Y304/1302
Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的L-精氨酸，L-瓜氨酸和L-赖氨酸等L-氨基酸的制造方法， 被修饰以减弱一个或多个基因的表达，例如pepA，pepB和pepD基因。
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公开(公告)号：US10428359B2
公开(公告)日：2019-10-01
申请号：US15717042
申请日：2017-09-27
Applicant: AJINOMOTO CO., INC.
Inventor： Mika Moriya , Kazuyuki Hayashi , Akari Yokokawa
IPC: C12P13/20 , C07C227/28 , C12P13/08 , C12P13/14 , C07K14/34 , C12N9/88 , C07C229/36 , C12N1/20 , C12N15/66 , C12Q1/686
Abstract: A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier such as DctA, DcuA, and DcuB is increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
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公开(公告)号：US20180291402A1
公开(公告)日：2018-10-11
申请号：US15927573
申请日：2018-03-21
Applicant: AJINOMOTO CO., INC.
Inventor： Yasushi Hoshino , Yoshiko Inoue , Mika Moriya , Akiko Matsudaira , Yosuke Nishio
Abstract: The present invention provides a composition containing linalool, wherein the composition contains a high amount of either enantiomer R-linalool or S-linalool, and has a high content rate of linalool. The present invention also provides a production method for producing the composition. The present invention further provides a composition containing volatile components including linalool, in which a content of linalool in a total content of the volatile components in the composition is 60% or more, and the linalool is present as R-linalool or S-linalool in an amount of 50% or more of the enantiomer, and a production method therefor.
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公开(公告)号：US20180291403A1
公开(公告)日：2018-10-11
申请号：US15927622
申请日：2018-03-21
Applicant: AJINOMOTO CO., INC.
Inventor： Yasushi Hoshino , Akiko Matsudaira , Mika Moriya , Nobuhisa Nitta , Yosuke Nishio
Abstract: The present invention describes an efficient method for producing linalool. The present invention provides a method for producing linalool, the method including culturing a microorganism expressing linalool synthase in a culture medium to produce linalool. The present invention also describes a microorganism able to express linalool synthase and efficiently produce linalool.
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Patent Agency Ranking
6.发明申请Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family, Having Attenuated Expression of Gene(s) Encoding Peptidase 有权使用肠杆菌科的细菌产生L-氨基酸的方法，其具有编码肽酶的基因的减弱表达公开(公告)号：US20130078682A1
公开(公告)日：2013-03-28
申请号：US13687541
申请日：2012-11-28
Applicant: AJINOMOTO CO., INC.
Inventor： Dmitriy Vladimirovich Filippov , Tatyana Viktorovna Leonova , Elvira Borisovna Voroshilova , Mikhail Markovich Gusyatiner , Mika Moriya , Yuri Nagai , Keiko Noguchi
CPC classification number: C12P13/10 , C12N1/20 , C12N9/485 , C12P13/08 , C12Y304/11006 , C12Y304/1101 , C12Y304/1302
Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
Abstract translation: 本发明提供了使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的L-精氨酸，L-瓜氨酸和L-赖氨酸等L-氨基酸的制造方法， 被修饰以减弱一个或多个基因的表达，例如pepA，pepB和pepD基因。
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公开(公告)号：US20230416793A1
公开(公告)日：2023-12-28
申请号：US18307947
申请日：2023-04-27
Applicant: Ajinomoto Co., Inc.
Inventor： Seiko Hirano , Kota Inoue , Kazuyuki Hayashi , Kosuke Yokota , Mika Moriya , Tomoko Suzuki , Yoshitomo Kadokura , Takeshi Nagahiko , Akari Tashiro
CPC classification number: C12P13/14 , C12N15/77 , C12N9/1217 , C12N9/16 , C12N9/0008 , C12N9/1096 , C12N9/0006 , C12N9/88 , C12R2001/15
Abstract: Provided is a method of producing an L-amino acid such as L-glutamic acid and the like. An L-amino-acid is produced by cultivating a coryneform bacterium having L-amino acid-producing ability in a culture medium, which has been modified so as to have one or more of the following modifications: (A) a modification for increasing activity of acetate kinase, (B) a modification for increasing activity of fructose-1,6-bisphosphatase, (C) a modification for decreasing activity of pyruvate dehydrogenase, (D) a modification for decreasing activity of aspartate transaminase, and (E) a modification for decreasing activity of malic enzyme; and collecting the L-amino acid from the culture medium and/or the bacterial cells.
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公开(公告)号：US20180094285A1
公开(公告)日：2018-04-05
申请号：US15717042
申请日：2017-09-27
Applicant: AJINOMOTO CO., INC.
Inventor： Mika Moriya , Kazuyuki Hayashi , Akari Yokokawa
IPC: C12P13/20 , C12P13/14 , C12P13/08 , C07C227/28
CPC classification number: C12P13/20 , C07C227/28 , C07C229/36 , C07K14/34 , C12N1/20 , C12N9/88 , C12N15/66 , C12P13/08 , C12P13/14 , C12Q1/686
Abstract: A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier such as DctA, DcuA, and DcuB is increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
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公开(公告)号：US09487806B2
公开(公告)日：2016-11-08
申请号：US14735303
申请日：2015-06-10
Applicant: AJINOMOTO CO., INC.
Inventor： Miku Toyazaki , Keiko Noguchi , Mika Moriya , Yuri Uehara
Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
Abstract translation: 提供了L-氨基酸的制造方法。 通过培养在培养基中培养属于肠杆菌科并具有L-氨基酸生产能力的细菌，其被修饰以使acpP-fabF操纵子减弱，产生L-氨基酸， 来自培养基的氨基酸或细菌的细胞。
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10.发明申请METHOD FOR PRODUCING CRYSTALS OF MUTIVALENT METAL SALT OF (2R, 4R) MONATIN 审中-公开生产（2R，4R）维生素的金属盐的晶体的方法公开(公告)号：US20130164792A1
公开(公告)日：2013-06-27
申请号：US13678909
申请日：2012-11-16
Applicant: Ajinomoto Co., Inc.
Inventor： Kenichi MORI , Masakazu Sugiyama , Mika Moriya , Shunichi Suzuki , Hidemi Fujii , Kyohei Fujiwara
IPC: C07D209/20 , C12P17/10
CPC classification number: C07D209/20 , C12P17/10 , C12Y206/01 , C12Y501/01
Abstract: The present invention provides a method of efficiently producing a crystal of a (2R,4R)Monatin multivalent metal salt that has a good sweetness property and is excellent in storage stability. Specifically, the present invention provides the method of producing the crystal of the (2R,4R)Monatin multivalent metal salt comprising allowing an aldehyde or one or two or more enzymes capable of forming (2R,4R)Monatin from (2S,4R)Monatin to be acted on an aqueous solution containing the (2S,4R)Monatin in the presence of a multivalent metal ion to obtain the crystal of the (2R,4R)Monatin multivalent metal salt. The aldehyde may preferably be an aromatic aldehyde. The one or two or more enzyme may preferably be a racemase or one or more aminotransferases. The multivalent metal may preferably be a bivalent alkaline earth metal.
Abstract translation: 本发明提供一种有效地制备具有良好的甜味性并且保存稳定性优异的（2R，4R）莫纳甜多金属盐晶体的方法。 具体地说，本发明提供了制备（2R，4R）莫纳甜多价金属盐晶体的方法，包括使（2，4R）莫纳甜能形成（2R，4R）莫纳甜的醛或一种或两种以上的酶 在含有（2S，4R）莫纳甜的水溶液中，在多价金属离子的存在下作用，得到（2R，4R）莫纳甜多晶金属盐的结晶。 醛可优选为芳族醛。 一种或两种或更多种酶可优选为消旋酶或一种或多种氨基转移酶。 多价金属可优选为二价碱土金属。
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