公开(公告)号：US20180327705A1

公开(公告)日：2018-11-15

申请号：US16019681

申请日：2018-06-27

Applicant: AJINOMOTO CO., INC.

Inventor： Shinichiro Matsuka ,  Nobuhisa Nitta

IPC: C12M1/04 ,  C12M1/00 ,  C12P5/02

CPC classification number: C12M27/04 ,  C12M1/08 ,  C12M23/02 ,  C12P5/00 ,  C12P5/026

Abstract: A gas stirring fermentation device has excellent mixing performance of a culture liquid and is applicable to aerobic culture requiring a high demanded oxygen amount. The gas stirring fermentation device includes a culture tank, a draft tube located inside the culture tank, and a gas supply pipe supplying gas to the inside of the culture tank, in which the gas supply pipe is provided with a gas discharge part made of a sintered metal film, and a culture liquid in the culture tank can be stirred by the gas discharged from the gas discharge part.

公开(公告)号：US20230212503A1

公开(公告)日：2023-07-06

申请号：US18063181

申请日：2022-12-08

Applicant: AJINOMOTO CO., INC.

Inventor： Nobuhisa Nitta ,  Hiroaki Fukada ,  Kazutaka Shimbo ,  Akiko Matsudaira ,  Toshiki Watanabe ,  Yoshihiro Usuda

IPC: C12N1/14

CPC classification number: C12N1/145 ,  C12N2501/734

Abstract: A method for producing a protein is provided. An objective protein is produced by culturing in a culture medium Talaromyces cellulolyticus having an objective protein-producing ability, which has been modified so that the activity of a Pep4 protein is reduced.

公开(公告)号：US20200339940A1

公开(公告)日：2020-10-29

申请号：US16928230

申请日：2020-07-14

Applicant: AJINOMOTO CO., INC.

Inventor： Satoshi Hioki ,  Ayumi Nakajima ,  Nobuhisa Nitta

IPC: C12M1/00 ,  B01D11/04 ,  C12M1/26 ,  C12P5/00

Abstract: An extraction method is aimed at extracting an object component by transferring the object component from a first liquid containing a microorganism and the object component to a second liquid to which the object component can be transferred and that is capable of causing phase separation from the first liquid, with use of a flow channel including a merging part, a flow part, and an outlet part. The extraction method includes a step of supplying the first liquid to the merging part, a step of supplying the second liquid to the merging part, a step of passing the first liquid and the second liquid supplied to the merging part, through the flow part, in a state where a phase of the first liquid and a phase of the second liquid are separated from each other, a step of discharging the first liquid and the second liquid passed through the flow part, from the outlet part, and a step of collecting the first liquid and the second liquid discharged from the outlet part, into a collector.

公开(公告)号：US20180291403A1

公开(公告)日：2018-10-11

申请号：US15927622

申请日：2018-03-21

Applicant: AJINOMOTO CO., INC.

Inventor： Yasushi Hoshino ,  Akiko Matsudaira ,  Mika Moriya ,  Nobuhisa Nitta ,  Yosuke Nishio

IPC: C12P7/04 ,  C12P5/00 ,  C12N15/70 ,  C12N15/74 ,  C12N9/88

Abstract: The present invention describes an efficient method for producing linalool. The present invention provides a method for producing linalool, the method including culturing a microorganism expressing linalool synthase in a culture medium to produce linalool. The present invention also describes a microorganism able to express linalool synthase and efficiently produce linalool.