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公开(公告)号：US11327060B2
公开(公告)日：2022-05-10
申请号：US15938450
申请日：2018-03-28
Applicant: Ajinomoto Co., Inc.
Inventor： Masashi Harada , Sachise Karakawa , Kazutaka Shimbo , Naoyuki Yamada
IPC: G01N30/00 , G01N30/88 , C07C271/58 , C07D401/12 , C07D207/46 , C07D213/40 , G01N30/06 , G01N27/62 , B01D15/38 , C07C233/62 , C07B57/00 , B01D15/32 , C07C51/353 , C07C51/47 , C07C53/18 , C07C269/06 , C07C269/08 , G01N1/40 , G01N30/72
Abstract: Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.
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公开(公告)号：US20180217113A1
公开(公告)日：2018-08-02
申请号：US15938450
申请日：2018-03-28
Applicant: Ajinomoto Co., Inc.
Inventor： Masashi Harada , Sachise Karakawa , Kazutaka Shimbo , Naoyuki Yamada
IPC: G01N30/88 , C07D207/46 , C07D401/12 , C07C271/58 , C07D213/40 , C07C53/18 , C07C51/47 , G01N1/40 , C07C269/08 , C07C269/06 , C07C51/353 , G01N27/62 , G01N30/06 , G01N30/72 , B01D15/32
CPC classification number: G01N30/88 , B01D15/327 , B01D15/38 , C07B57/00 , C07B2200/07 , C07C51/353 , C07C51/47 , C07C53/18 , C07C233/62 , C07C269/06 , C07C269/08 , C07C271/58 , C07D207/46 , C07D213/40 , C07D401/12 , G01N1/405 , G01N27/62 , G01N30/06 , G01N30/7233
Abstract: Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.
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公开(公告)号：US20190137516A1
公开(公告)日：2019-05-09
申请号：US16239834
申请日：2019-01-04
Applicant: AJINOMOTO CO., INC.
Inventor： Takeshi Ikeuchi , Yuki Yano , Naoko Arashida , Rumi Nishimoto , Kazutaka Shimbo , Nobuhiro Kawai
Abstract: An evaluating method includes an evaluating step of evaluating future risk of developing Alzheimer's disease for a subject to be evaluated having mild cognitive impairment using a concentration value of at least one of α-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, bABA, Ethylglycine, Hypotaurine, 3-Me-His, 5-HydroxyTrp, aAiBA, and N8-Acetylspermidine in blood of the subject.
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公开(公告)号：US09952235B2
公开(公告)日：2018-04-24
申请号：US15450135
申请日：2017-03-06
Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD. , AJINOMOTO CO., INC.
Inventor： Masako Hayakawa , Kazutaka Shimbo , Hiroo Yoshida
CPC classification number: G01N33/96 , G01N33/6806 , G01N33/6848 , G01N2030/042 , G01N2496/80 , Y10T436/105831 , Y10T436/106664
Abstract: An external standard solution for use in the analysis of amino acid in plasma, containing, (1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A; [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.
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公开(公告)号：US12024549B2
公开(公告)日：2024-07-02
申请号：US16663791
申请日：2019-10-25
Applicant: Ajinomoto Co., Inc.
Inventor： Kei Yamada , Yutaka Matsuda , Tomohiro Fujii , Natsuki Shikida , Reiko Yuji , Kazutaka Shimbo , Yuji Ito
CPC classification number: C07K16/00 , C07K19/00 , C07K2317/52
Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I):
A-L-B-R (I)
wherein
A is an affinity substance to a soluble protein;
L is a cleavable linker which is a divalent group comprising a cleavable portion;
B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and
R is a reactive group to the soluble protein; or
a salt thereof.-
Patent Agency Ranking
公开(公告)号：US20200318093A1
公开(公告)日：2020-10-08
申请号：US16897482
申请日：2020-06-10
Applicant: AJINOMOTO CO., INC.
Inventor： Noriko YOKOYAMA , Mayu Nakano , Shuhei Hashiro , Masako Hiraga , Kazutaka Shimbo , Ayaka Tokunaga
Abstract: A novel protein deamidase having an activity of directly acting on a side chain amide group of an asparagine residue in a protein to form a side chain carboxyl group and release ammonia, a microorganism that produces the same, a gene encoding the same, a method for producing the same, and use of the same are provided. A bacterium classified into the class Actinobacteria is cultured to generate protein deamidase, and the enzyme is collected from culture.
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公开(公告)号：US10717971B2
公开(公告)日：2020-07-21
申请号：US15252664
申请日：2016-08-31
Applicant: AJINOMOTO CO., INC.
Inventor： Noriko Yokoyama , Mayu Nakano , Shuhei Hashiro , Masako Hiraga , Kazutaka Shimbo , Ayaka Tokunaga
IPC: C12N9/82 , C12N15/52 , C12N9/78 , A23C13/16 , C12P21/00 , A21D2/26 , A23C9/12 , A23L27/60 , A23L13/40 , A23L11/00
Abstract: A novel protein deamidase having an activity of directly acting on a side chain amide group of an asparagine residue in a protein to form a side chain carboxyl group and release ammonia, a microorganism that produces the same, a gene encoding the same, a method for producing the same, and use of the same are provided. A bacterium classified into the class Actinobacteria is cultured to generate protein deamidase, and the enzyme is collected from culture.
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公开(公告)号：US09658234B2
公开(公告)日：2017-05-23
申请号：US15003235
申请日：2016-01-21
Applicant: AJINOMOTO CO., INC.
Inventor： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
IPC: G01N30/72 , G01N33/68 , G01N33/58 , C07D207/46
CPC classification number: G01N33/58 , C07D207/46 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2458/15 , G01N2560/00 , Y10T436/13 , Y10T436/14 , Y10T436/145555 , Y10T436/24
Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.
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公开(公告)号：US20230212503A1
公开(公告)日：2023-07-06
申请号：US18063181
申请日：2022-12-08
Applicant: AJINOMOTO CO., INC.
Inventor： Nobuhisa Nitta , Hiroaki Fukada , Kazutaka Shimbo , Akiko Matsudaira , Toshiki Watanabe , Yoshihiro Usuda
IPC: C12N1/14
CPC classification number: C12N1/145 , C12N2501/734
Abstract: A method for producing a protein is provided. An objective protein is produced by culturing in a culture medium Talaromyces cellulolyticus having an objective protein-producing ability, which has been modified so that the activity of a Pep4 protein is reduced.
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公开(公告)号：US10941390B2
公开(公告)日：2021-03-09
申请号：US16897482
申请日：2020-06-10
Applicant: AJINOMOTO CO., INC.
Inventor： Noriko Yokoyama , Mayu Nakano , Shuhei Hashiro , Masako Hiraga , Kazutaka Shimbo , Ayaka Tokunaga
IPC: C12N9/82 , A23L27/60 , A23L13/00 , A23C13/16 , C12P21/00 , A21D2/26 , A23C9/12 , A23L13/40 , A23L11/00
Abstract: A novel protein deamidase having an activity of directly acting on a side chain amide group of an asparagine residue in a protein to form a side chain carboxyl group and release ammonia, a microorganism that produces the same, a gene encoding the same, a method for producing the same, and use of the same are provided. A bacterium classified into the class Actinobacteria is cultured to generate protein deamidase, and the enzyme is collected from culture.
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