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公开(公告)号：US11208377B2
公开(公告)日：2021-12-28
申请号：US16103607
申请日：2018-08-14
Applicant: ALLERGAN, INC.
Inventor： Christopher D. Hein , Tien T. Duong , Santosh Sinha , Ling Li , Jeremiah H. Nguyen , David W. Old , Robert Burk , Veena Viswanath , Sandhya Rao , John E. Donello
IPC: C07C311/39 , A61P17/06 , C07C237/44 , A61P27/02 , C07C211/52 , C07D307/36 , C07D307/79 , C07D215/42 , C07B59/00 , C07D333/54 , C07C311/43 , A61P29/00
Abstract: Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.
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2.发明授权公开(公告)号：US09540357B1
公开(公告)日：2017-01-10
申请号：US14501760
申请日：2014-09-30
Applicant: Allergan, Inc.
Inventor： Vinh X. Ngo , David W. Old , Robert M. Burk
IPC: C07D207/27 , C07D409/06
CPC classification number: C07D409/06 , C07D207/27
Abstract: The invention provides compositions and methods for reducing healing wounds and reducing scars and blemishes. The compositions and methods of the invention include at least one EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.
Abstract translation: 本发明提供用于减少愈合伤口并减少疤痕和瑕疵的组合物和方法。 本发明的组合物和方法包括本文所述的至少一种EP4激动剂。 可以通过本发明的组合物和方法治疗的伤口和/或伤痕可以由诸如手术，创伤，疾病，机械损伤，烧伤，辐射，中毒等事件引起。
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公开(公告)号：US09415027B2
公开(公告)日：2016-08-16
申请号：US14725732
申请日：2015-05-29
Applicant: Allergan, Inc.
Inventor： David W. Old
IPC: C07D333/40 , C07C65/36 , C07C65/40 , A61K31/381 , A61K31/192
CPC classification number: A61K31/192 , A61K31/381 , C07C65/36 , C07C65/40 , C07C2602/08 , C07C2602/10 , C07D333/40
Abstract: The invention provides well-defined compounds that are either EP2 agonists, EP4 agonists, or mixed EP2/EP4 agonist. The compounds are useful for treating a variety of pathological conditions associated with activity of the EP2 and/or EP4 receptors.
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公开(公告)号：US20150274658A1
公开(公告)日：2015-10-01
申请号：US14227743
申请日：2014-03-27
Applicant: Allergan, Inc.
Inventor： David W. Old , Robert M. Burk
IPC: C07D207/273 , C07D405/12 , C07D403/12 , C07D409/14 , C07D417/14 , C07D417/06 , C07D409/06
CPC classification number: C07D207/273 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14
Abstract: Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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公开(公告)号：US20150175586A1
公开(公告)日：2015-06-25
申请号：US14136089
申请日：2013-12-20
Applicant: Allergan, Inc.
Inventor： David W. Old
IPC: C07D409/12 , C07D333/24 , C07D215/14 , C07C235/78
CPC classification number: C07D409/12 , C07C233/75 , C07C235/66 , C07C235/78 , C07D215/14 , C07D333/24
Abstract: This invention provides well defined 6-alkyl or hydroxyalkyl-1-naphthamide or quinoline compounds for treating glaucoma or ocular hypertension.
Abstract translation: 本发明提供了用于治疗青光眼或高眼压症的明确定义的6-烷基或羟基烷基-1-萘甲酰胺或喹啉化合物。
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Patent Agency Ranking
公开(公告)号：US20220402866A1
公开(公告)日：2022-12-22
申请号：US17545940
申请日：2021-12-08
Applicant: Allergan, Inc.
Inventor： Christopher D. Hein , Tien T. Duong , Santosh Sinha , Ling Li , Jeremiah H. Nguyen , David W. Old , Robert Burk , Veena Viswanath , Sandhya Rao , John E. Donello
IPC: C07C311/39 , A61P17/06 , C07C237/44 , A61P27/02 , C07C211/52 , C07D307/36 , C07D307/79 , C07D215/42 , C07B59/00 , C07D333/54 , C07C311/43 , A61P29/00
Abstract: Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.
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公开(公告)号：US10407382B2
公开(公告)日：2019-09-10
申请号：US15899867
申请日：2018-02-20
Applicant: ALLERGAN, INC.
Inventor： David W. Old , Christopher D. Hein
IPC: C07C235/40 , C07C233/63 , A61K31/164
Abstract: Described herein are compounds that are EP4 agonists and antagonists which are useful for treating a variety of pathological conditions associated with activity of EP4 receptors.
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公开(公告)号：US20150175567A1
公开(公告)日：2015-06-25
申请号：US14565817
申请日：2014-12-10
Applicant: Allergan, Inc.
Inventor： Vinh X. Ngo , David W. Old
IPC: C07D307/82 , C07C233/81 , C07C59/72 , C07C217/84
CPC classification number: C07D307/82 , A61K31/136 , A61K31/196 , C07C59/72 , C07C217/84 , C07C233/81
Abstract: Compounds such as those represented by Formulas 1-6 can be used in topical liquids, creams, or other dosage forms such as solids, for reducing intraocular pressure, treating glaucoma, growing hair, or other medical uses.
Abstract translation: 化合物如由式1-6表示的化合物可用于局部液体，霜剂或其他剂型如固体，用于降低眼内压，治疗青光眼，生长发或其它医学用途。
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公开(公告)号：US20180170858A1
公开(公告)日：2018-06-21
申请号：US15899867
申请日：2018-02-20
Applicant: ALLERGAN, INC.
Inventor： David W. Old , Christopher D. Hein
IPC: C07C235/40 , C07C233/63
CPC classification number: C07C235/40 , A61K31/164 , C07C233/63 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42
Abstract: Described herein are compounds that are EP4 agonists and antagonists which are useful for treating a variety of pathological conditions associated with activity of EP4 receptors.
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公开(公告)号：US09981938B2
公开(公告)日：2018-05-29
申请号：US15310738
申请日：2015-05-12
Applicant: ALLERGAN, INC.
Inventor： Robert M. Burk , David W. Old , Wha Bin Im , Richard S. Graham , Mu-Lan Lee
IPC: C07D333/40 , A61K31/5575 , A61K31/381 , A61P27/06 , A61Q7/00 , C07D333/38
CPC classification number: C07D333/38 , C07D333/40
Abstract: Disclosed herein are compounds according to Formulas 1-12, compositions comprising these compounds, and methods of lowering intraocular pressure (IOP) or causing hair growth, and methods of using the same.
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