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公开(公告)号：US09604965B2
公开(公告)日：2017-03-28
申请号：US14594274
申请日：2015-01-12
申请人： Cytokinetics, Inc.
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/50 , C07D237/20 , C07D401/12 , C07D237/24 , C07D401/04 , C07D403/04 , C07D403/06 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , C07D401/14 , C07D405/14
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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2.发明申请公开(公告)号：US20160200717A1
公开(公告)日：2016-07-14
申请号：US14823605
申请日：2015-08-11
申请人： Cytokinetics, Inc.
发明人： Luke W. Ashcroft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D417/14 , C07D213/75 , C07D401/14 , C07D253/07 , C07D403/04 , C07D213/74 , C07D401/12
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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3.发明申请SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION 审中-公开替代苯甲醛化合物及其在增加组织氧化中的用途公开(公告)号：US20150344472A1
公开(公告)日：2015-12-03
申请号：US14662156
申请日：2015-03-18
申请人： Global Blood Therapeutics, Inc. , Cytokinetics, Inc. , The Regents of the University of California
发明人： Brian Metcalf , Chihyuan Chuang , Jeffrey Warrington , Kumar Paulvannan , Matthew P. Jacobson , Lan Hua , Bradley Morgan
IPC分类号： C07D471/04 , C07D215/14 , C07D257/04 , C07D213/80 , C07D211/62 , C07D231/56 , C07D401/04
CPC分类号： A61K31/4985 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47 , C07C65/30 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
摘要翻译： 提供作为血红蛋白的变构调节剂的取代的苯甲醛及其衍生物，其制备方法和中间体，包含调节剂的药物组合物，及其用于治疗血红蛋白介导的疾病的方法以及将受益于组织氧合增加的病症。
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公开(公告)号：US11369565B2
公开(公告)日：2022-06-28
申请号：US16941079
申请日：2020-07-28
申请人： Cytokinetics, Inc.
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： A61K9/14 , A61K9/00 , C07D403/04 , C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07D401/14 , C07D403/10
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and mare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.
Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US10076519B2
公开(公告)日：2018-09-18
申请号：US15463288
申请日：2017-03-20
申请人： CYTOKINETICS, INC.
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R. Muci , Xiangping Qian , Jeffrey Warrington , Zhe Yang , Pu-Ping Lu , Antonio Romero
IPC分类号： A61K31/501 , C07D403/02 , A61K31/50 , C07D237/06 , C07D231/56 , A61K31/16 , A61K31/166 , C07D213/16 , C07D207/26 , C07D211/76
CPC分类号： A61K31/50 , A61K31/16 , A61K31/166 , C07D207/26 , C07D211/76 , C07D213/16 , C07D231/56 , C07D237/06 , C07D237/20 , C07D237/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D513/04 , Y02A50/465
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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6.发明申请SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION 审中-公开替代异氟醚化合物及其用于增加组织氧化的方法公开(公告)号：US20150344483A1
公开(公告)日：2015-12-03
申请号：US14662145
申请日：2015-03-18
申请人： Global Blood Therapeutics, Inc. , Cytokinetics, Inc. , The Regents of the University of Califorina
发明人： Brian Metcalf , Chihyuan Chuang , Jeffrey Warrington , Kumar Paulvannan , Matthew P. Jacobson , Lan Hua , Bradley Morgan
IPC分类号： C07D487/04 , C07D471/04 , C07D213/69 , C07D213/65 , C07D401/12 , C07D401/14 , C07D213/80 , C07D405/14 , C07D213/68 , C07D413/12
CPC分类号： C07D401/12 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/80 , C07D401/14 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
摘要翻译： 提供作为血红蛋白的变构调节剂的取代的杂芳基醛及其衍生物，其制备方法和中间体，包含调节剂的药物组合物，及其用于治疗血红蛋白介导的疾病的方法以及将受益于组织氧合增加的病症。
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7.发明申请公开(公告)号：US20130190315A1
公开(公告)日：2013-07-25
申请号：US13730674
申请日：2012-12-28
申请人： Global Blood Therapeutics, Inc. , Cytokinetics, Inc. , The Regents of the University of California
发明人： Brian Metcalf , Chihyuan Chuang , Jeffrey Warrington , Kumar Paulvannan , Matthew P. Jacobson , Lan Hua , Bradley Morgan
IPC分类号： C07D487/04 , C07D215/14 , C07D471/04
CPC分类号： A61K31/4985 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47 , C07C65/30 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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8.发明授权公开(公告)号：US09994528B2
公开(公告)日：2018-06-12
申请号：US14823605
申请日：2015-08-11
申请人： Cytokinetics, Inc.
发明人： Luke W. Ashcraft , Gustave Bergnes , Scott Collibee , Chihyuan Chuang , Jeff Gardina , Bradley P. Morgan , Alex R Muci , Xiangping Qian , Antonio Romero , Jeffrey Warrington , Zhe Yang
IPC分类号： C07D213/74 , C07D213/75 , C07D401/12 , C07D401/14 , C07D417/14 , C07D417/04 , C07D403/04 , A61K31/44 , A61K31/4427 , A61P21/00 , A61P21/04 , C07D213/78 , C07D213/82 , C07D215/48 , C07D253/07 , C07D215/38 , C07D403/10
CPC分类号： C07D213/74 , C07D213/75 , C07D213/78 , C07D213/82 , C07D215/38 , C07D215/48 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D417/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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9.发明申请公开(公告)号：US20130190316A1
公开(公告)日：2013-07-25
申请号：US13730730
申请日：2012-12-28
申请人： Global Blood Therapeutics, Inc. , Cytokinetics, Inc. , The Regents of the University of California
发明人： Brian Metcalf , Chihyuan Chuang , Jeffrey Warrington , Kumar Paulvannan , Matthew P. Jacobson , Lan Hua , Bradley Morgan
IPC分类号： C07D487/04 , C07D471/04 , C07D213/80
CPC分类号： C07D401/12 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/80 , C07D401/14 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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公开(公告)号：US10765624B2
公开(公告)日：2020-09-08
申请号：US16352626
申请日：2019-03-13
申请人： Cytokinetics, Inc.
发明人： Zhe Yang , Alex R. Muci , Jeffrey Warrington , Gustave Bergnes , Bradley P. Morgan , Chihyuan Chuang , Antonio Romero , Scott Collibee , Xiangping Qian , Pu-Ping Lu
IPC分类号： A61K9/00 , C07D403/04 , C07D239/42 , C07D513/04 , C07D495/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D409/14 , C07D401/14 , C07D401/12 , C07D239/48 , C07D403/10 , C07D401/04 , C07D417/14
摘要： Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
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