公开(公告)号：US12031235B2

公开(公告)日：2024-07-09

申请号：US17151308

申请日：2021-01-18

申请人： AMOGREENTECH CO., LTD.

发明人： Chan Kim ,  Seung Hoon Lee ,  Seon Ho Jang ,  Ji Hyun Lee ,  Yun Mi So

IPC分类号： A61L27/54 ,  A61F2/07 ,  A61L24/00 ,  A61L27/12 ,  A61L27/26 ,  A61L31/16 ,  D01D5/00 ,  D01F1/10 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： D01D5/003 ,  A61L24/0042 ,  A61L27/12 ,  A61L27/26 ,  A61L2300/112 ,  A61L2300/20 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/38 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： Provided is a nanofiber composite membrane for guided bone regeneration, which includes: spinning a spinning solution by an electrospinning method to produce nanofibers; accumulating the nanofibers, to prepare a certain thickness of a nanofiber web; and drying and thermally calendering the nanofiber web to sterilize the nanofiber web, wherein the spinning solution contains a biocompatible plasticizer to maintain physical properties, flexibility and elasticity of the membrane, by suppressing an increase in brittleness in a sterilization treatment.

公开(公告)号：US20160355780A1

公开(公告)日：2016-12-08

申请号：US15173488

申请日：2016-06-03

申请人： AMOGREENTECH CO., LTD. ,  Kollodis BioSciences, Inc.

发明人： Chan Kim ,  Kyuwon Baek ,  Hui-Gwan Goo ,  Sangjae Lee ,  Bongjin Hong ,  Song Hee Koo ,  In Yong Seo ,  Seung Hoon Lee ,  Ji Hyun Lee ,  Seonho Jang ,  Dong-Sik Seo

IPC分类号： C12N5/00 ,  D01F1/10 ,  D01F6/66 ,  D01F6/18 ,  D01F6/32 ,  C12N5/0735 ,  D01F6/12

CPC分类号： C12N5/0062 ,  C12N5/0075 ,  C12N5/0606 ,  C12N2513/00 ,  C12N2533/32 ,  C12N2535/10 ,  D01D5/003 ,  D01F1/10 ,  D01F6/12 ,  D01F6/18 ,  D01F6/32 ,  D01F6/44 ,  D01F6/66 ,  D01F6/88

摘要： This disclosure provides a three-dimensional (3D) microenvironment presenting defined biochemical and physical cues that regulate cellular behavior and use of the microenvironment. A composition to form the 3D microenvironment is provided by combining one or more natural or synthetic polymeric materials and substrate proteins recombinantly or chemically functionalized with a variety of bioactive peptides such as extracellular matrix-derived or growth factor-derived peptides. The disclosure also provides for devices and methods for screening for optimal combinations of the bioactive motifs in order to create an extracellular microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation.

摘要翻译： 本公开提供了三维（3D）微环境，其显示了调节细胞行为和微环境的使用的定义的生物化学和物理线索。 通过将一种或多种天然或合成聚合物材料和底物蛋白质与多种生物活性肽如细胞外基质衍生或生长因子衍生肽重组或化学官能化组合来提供形成3D微环境的组合物。 本公开还提供用于筛选生物活性基序的最佳组合的装置和方法，以便产生可以调节特定细胞行为如细胞生长，增殖，迁移或分化的细胞外微环境。

公开(公告)号：US11013580B2

公开(公告)日：2021-05-25

申请号：US16658655

申请日：2019-10-21

申请人： AMOGREENTECH CO., LTD.

发明人： Chan Kim ,  Seung Hoon Lee ,  Song Hee Koo ,  Ji Hyun Lee

IPC分类号： D01F2/26 ,  D01F6/10 ,  D01F6/12 ,  D01F6/14 ,  D01F6/16 ,  D01F6/22 ,  D01F6/60 ,  D01F6/70 ,  D02G1/02 ,  D02G3/04 ,  D02G3/06 ,  D02G3/38 ,  D02J1/22 ,  D04H3/16 ,  A61C9/00 ,  A61L31/16 ,  D02G3/36 ,  A61C19/06 ,  A61L31/04 ,  A61L31/14 ,  D01D4/02 ,  D01D5/00 ,  D01D7/00 ,  D01F8/04 ,  D02G3/40 ,  D02G3/44 ,  D01F6/18 ,  D01D5/42 ,  B32B38/00 ,  B32B37/15

摘要： Provided is a method of manufacturing a dental cord. The method including: producing a spinning solution by dissolving a fiber-moldable hydrophobic polymer material in a solvent; spinning the spinning solution to obtain a polymer nanofiber web composed of nanofibers and including three-dimensional micropores; laminating the polymer nanofiber web to obtain a polymer membrane; slitting the polymer membrane to obtain a nanofiber tape yarn; hydrophilic-treating the nanofiber tape yarn to obtain a hydrophilic-treated nanofiber tape yarn; plying and twisting the hydrophilic-treated nanofiber tape yarn with a covered yarn to obtain a nanofiber multiple yarn; and impregnating the nanofiber multiple yarn with a hemostatic agent.