公开(公告)号：US20150290099A1

公开(公告)日：2015-10-15

申请号：US14648687

申请日：2013-11-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Won Hee Jang ,  Yung Hyup Joo ,  Yang Hui Park ,  Chang Geun Yi ,  Young Suk Cho ,  Heung Soo Baek ,  Song Seok Shin ,  Young Ho Park

IPC: A61K8/42 ,  A61Q19/00

CPC classification number: A61K8/42 ,  A61K8/68 ,  A61K2800/40 ,  A61Q19/007 ,  C07C233/18 ,  C07C235/08 ,  C07C235/28

Abstract: The present invention provides: a novel pseudoceramide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof. The present invention has a skin protecting effect in that the invention has a superior effect in skin moisturisation and is outstandingly stable and soluble, and thus the invention can protect the skin from external irritation without side effects, and can be used as an active substance in damaged skin recovery and prevention. Consequently, the invention can be used as a skin-moisturising dermatological external composition, cosmetic composition or pharmaceutical composition.

Abstract translation: 本发明提供：新颖的假花生酰胺化合物，其异构体，其药学上可接受的盐，其前药，其水合物或其溶剂化物。 本发明具有皮肤保护作用，因为本发明在皮肤保湿中具有优异的效果，并且具有优异的稳定和可溶性，因此本发明可以保护皮肤免受外部刺激而没有副作用，并可用作活性物质 皮肤恢复和预防受损。 因此，本发明可以用作皮肤保湿皮肤病外用组合物，化妆品组合物或药物组合物。

公开(公告)号：US09433593B1

公开(公告)日：2016-09-06

申请号：US15085628

申请日：2016-03-30

Applicant: Amorepacific Corporation

Inventor： Yung Hyup Joo ,  Heung Soo Baek ,  Jeong Hwan Kim ,  Chang Geun Yi ,  Hyung Jun Lim ,  Hong-Ju Shin ,  Yongjin Kim ,  Jon Hwan Lee

IPC: A61K31/166 ,  A61K9/20 ,  A61K9/16 ,  A61K9/06 ,  A23L1/30 ,  A61K9/00

CPC classification number: A61K31/166 ,  A23G1/42 ,  A23G3/36 ,  A23G4/12 ,  A23G9/36 ,  A23L33/00 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1652 ,  A61K9/2059

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-κB and AP-1 or by inhibiting proinflammatory cytokines such as IL-1β.

Abstract translation: 本发明公开的5-金刚烷-1-基-N-（2,4-二羟基苄基）-2,4-二甲氧基苯甲酰胺缺乏毒性，可表现出优异的抗炎作用。 通过抑制一种或多种转录因子NF-κB和AP-1的活性或通过抑制促炎细胞因子，例如通过抑制NO和PGE2中的一种或多种的产生，显示出优异的抗炎作用 IL-1β。