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公开(公告)号：US20180065918A1
公开(公告)日：2018-03-08
申请号：US15492898
申请日：2017-04-20
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: C07C219/06 , C07C323/25 , C07C271/10 , C07C233/36 , A61K9/127 , C07C209/78 , A61K31/325 , A61K47/34
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
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公开(公告)号：US09764036B2
公开(公告)日：2017-09-19
申请号：US14953677
申请日：2015-11-30
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Jayaprakash K. Nair , Muthusamy Jayaraman , Laxman Eltepu
IPC: A61K47/44 , C07D491/113 , C07D317/72 , C07D317/46 , C07D405/12 , A61K31/7088 , C07D491/056 , C07D317/44 , C07D317/28 , A61K31/713
CPC classification number: A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:
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公开(公告)号：US20230174459A1
公开(公告)日：2023-06-08
申请号：US17863885
申请日：2022-07-13
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: C07C219/06 , A61K9/127 , A61K31/325 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25
CPC classification number: C07C219/06 , A61K9/1272 , A61K9/1273 , A61K31/325 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25 , A61K47/34
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
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公开(公告)号：US11420931B2
公开(公告)日：2022-08-23
申请号：US16713712
申请日：2019-12-13
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: C07C219/06 , A61K9/127 , A61K31/325 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25 , A61K47/34
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
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公开(公告)号：US20180064807A1
公开(公告)日：2018-03-08
申请号：US15474911
申请日：2017-03-30
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Jayaprakash K. Nair , Muthusamy Jayaraman , Laxman Eltepu
IPC: A61K39/39 , C12N15/113 , A61K9/127 , C07D203/10 , C07D317/28 , C07D319/06 , A61K31/713 , C07C229/08 , C07C251/38 , A61K47/18 , A61K47/20 , A61K47/28 , C07C237/16 , C07C323/25 , C07C251/78 , C07C271/12 , C07C271/20 , A61K47/10 , C12N15/11
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure:
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Patent Agency Ranking
公开(公告)号：US09814777B2
公开(公告)日：2017-11-14
申请号：US14060353
申请日：2013-10-22
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Nair , Muthusamy Jayaraman
IPC: A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/22 , A61K47/28 , A61K31/7004 , A61K31/7052 , A61K31/70 , A61K47/48 , C07H21/02 , A61K48/00
CPC classification number: A61K47/28 , A61K31/70 , A61K31/7004 , A61K31/7052 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/22 , A61K47/543 , A61K47/549 , A61K47/60 , A61K48/00 , C07H21/02 , Y02A50/385 , Y02A50/411 , Y02A50/467 , Y02P20/55
Abstract: The present invention provides targeting lipids of structure L100-linker-L101 (CI), where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or —CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.
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公开(公告)号：US20170143631A1
公开(公告)日：2017-05-25
申请号：US15187633
申请日：2016-06-20
Applicant: Arbutus Biopharma Corporation
Inventor： Jianxin Chen , Steven Ansell , Akin Akinc , Joseph Robert Dorkin , Xiaojun Qin , William Cantley , Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Nair , Muthusamy Jayaraman
IPC: A61K9/127 , A61K31/713 , A61K31/712 , C12N15/113
CPC classification number: A61K9/1272 , A61K9/1278 , A61K31/22 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K38/1709 , A61K38/4846 , A61K47/14 , A61K47/549 , A61K47/551 , A61K47/6911 , A61K48/0033 , A61P9/00 , A61P25/28 , C07C29/58 , C07C227/18 , C07C227/40 , C07C229/12 , C07D475/04 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , Y02A50/463 , A61K2300/00 , C12N2310/3521 , C12N2310/3533
Abstract: The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.
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公开(公告)号：US20190167800A1
公开(公告)日：2019-06-06
申请号：US16123209
申请日：2018-09-06
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Nair , Martin Maier , Laxman Eltepu
IPC: A61K47/44 , C07D317/28 , A61K47/10 , C12N15/113 , C07C229/30 , C07D319/06 , C07D203/10 , A61K31/713 , A61K39/39 , A61K47/28 , C07C229/08 , C07C271/12 , C07C251/38 , C07D317/72 , A61K9/127 , C07C323/25 , C12N15/11 , A61K47/18 , C07D491/113 , C07C271/20 , C07C237/16 , A61K31/7088 , C07D405/12 , C07D317/46 , A61K47/20 , A61K39/00 , C07C251/78 , C07D317/44 , C07D491/056
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.
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公开(公告)号：US10117941B2
公开(公告)日：2018-11-06
申请号：US15603069
申请日：2017-05-23
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Nair , Martin Maier , Laxman Eltepu
IPC: A61K39/39 , C07D203/10 , A61K47/18 , A61K47/28 , A61K31/713 , A61K39/00 , A61K47/44 , C07C229/08 , C07C229/30 , C07D317/28 , C07D319/06 , C12N15/113 , A61K9/127 , C12N15/11 , A61K47/10 , A61K47/20 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , A61K31/7088 , C07D317/44 , C07D317/46 , C07D317/72 , C07D405/12 , C07D491/056 , C07D491/113
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.
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公开(公告)号：US09663449B2
公开(公告)日：2017-05-30
申请号：US14149496
申请日：2014-01-07
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: A61K9/48 , C07C229/00 , A61K9/127 , A61K47/34 , C07C233/36 , C07C209/78 , C07C219/06 , A61K31/325 , C07C271/10 , C07C323/25
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
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