-
公开(公告)号：US20240424105A1
公开(公告)日：2024-12-26
申请号：US18736363
申请日：2024-06-06
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , Laxman Eltepu , Steven Ansell , Jianxin Chen
IPC: A61K47/44 , A61K9/127 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/11 , C12N15/113
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).
-
公开(公告)号：US20180092971A1
公开(公告)日：2018-04-05
申请号：US15617520
申请日：2017-06-08
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , Laxman Eltepu , Steven Ansell , Jianxin Chen
IPC: A61K39/39 , A61K9/127 , A61K31/713 , A61K39/00 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D319/06 , C12N15/11 , C12N15/113
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure XXXIII, wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).
-
公开(公告)号：US20180065918A1
公开(公告)日：2018-03-08
申请号：US15492898
申请日：2017-04-20
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: C07C219/06 , C07C323/25 , C07C271/10 , C07C233/36 , A61K9/127 , C07C209/78 , A61K31/325 , A61K47/34
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
-
4.发明授权
公开(公告)号：US09895448B2
公开(公告)日：2018-02-20
申请号：US15133010
申请日：2016-04-19
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Muthusamy Jayaraman
CPC classification number: A61K47/554 , A61K47/545 , A61K47/549 , A61K47/551 , A61K48/0008 , C12N15/111 , C12N15/1137 , C12N15/87 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/346 , C12N2310/351 , C12N2310/3513 , C12N2320/32 , C12Y304/21021
Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.
-
公开(公告)号：US09764036B2
公开(公告)日：2017-09-19
申请号：US14953677
申请日：2015-11-30
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Jayaprakash K. Nair , Muthusamy Jayaraman , Laxman Eltepu
IPC: A61K47/44 , C07D491/113 , C07D317/72 , C07D317/46 , C07D405/12 , A61K31/7088 , C07D491/056 , C07D317/44 , C07D317/28 , A61K31/713
CPC classification number: A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:
-
公开(公告)号：US12042541B2
公开(公告)日：2024-07-23
申请号：US18194540
申请日：2023-03-31
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , Laxman Eltepu , Steven Ansell , Jianxin Chen
IPC: A61K47/44 , A61K9/127 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/11 , C12N15/113
CPC classification number: A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , A61K2039/55555 , A61K2039/55561 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/30
Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure
wherein:
R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).
-
公开(公告)号：US20230174459A1
公开(公告)日：2023-06-08
申请号：US17863885
申请日：2022-07-13
Applicant: ARBUTUS BIOPHARMA CORPORATION
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: C07C219/06 , A61K9/127 , A61K31/325 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25
CPC classification number: C07C219/06 , A61K9/1272 , A61K9/1273 , A61K31/325 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25 , A61K47/34
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
-
公开(公告)号：US11420931B2
公开(公告)日：2022-08-23
申请号：US16713712
申请日：2019-12-13
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Jayaprakash K. Nair , Muthusamy Jayaraman , Martin Maier
IPC: C07C219/06 , A61K9/127 , A61K31/325 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25 , A61K47/34
Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
-
公开(公告)号：US10456473B2
公开(公告)日：2019-10-29
申请号：US15594244
申请日：2017-05-12
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Michael E. Jung
IPC: A61K47/22 , A61K9/127 , C07D295/13 , C12N15/113
Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
-
公开(公告)号：US20180369384A1
公开(公告)日：2018-12-27
申请号：US15596845
申请日：2017-05-16
Applicant: Arbutus Biopharma Corporation
Inventor： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Mamta Kapoor , Rajesh Kumar Kainthan
IPC: A61K47/18 , C12N15/88 , C07D491/10 , C07D317/72 , C07D317/44 , C07D317/28 , C07C323/25 , C07C271/20 , C07C271/12 , C07C251/40 , C07C229/12 , C07C219/08 , C07C217/08 , A61K47/22 , A61K31/713 , A61K31/7105
Abstract: The present invention is based, in part, upon the discovery of charged lipids that provide advantages when used in lipid particles for the in vivo delivery of a therapeutic agent. As such, described herein are compounds useful for delivering a nucleic acid to a cell.
