公开(公告)号：US11085929B2

公开(公告)日：2021-08-10

申请号：US16119100

申请日：2018-08-31

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  The Methodist Hospital

Inventor： Ye Hu ,  Yang Bu

IPC: G01N33/68 ,  C01G23/053 ,  C01G23/08

Abstract: Certain embodiments of the invention provide TiO2 nanoshell particles, methods of fabricating TiO2 nanoshell particles, and methods of enriching peptides in a sample using TiO2 nanoshell particles.

公开(公告)号：US20230314427A1

公开(公告)日：2023-10-05

申请号：US17617802

申请日：2020-06-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Ye Hu ,  Xiangxing Kong ,  Tanxi Cai ,  Qingbo Shu

IPC: G01N33/569 ,  G01N33/68 ,  G01N33/543

CPC classification number: G01N33/569 ,  G01N33/6848 ,  G01N33/54326 ,  G01N2458/15 ,  G01N2446/00 ,  G01N2333/35

Abstract: Provided herein are methods for detecting and identifying disease-specific biomarkers, such as target antigens associated with infection.

公开(公告)号：US12072479B2

公开(公告)日：2024-08-27

申请号：US18069572

申请日：2022-12-21

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Ye Hu ,  Dali Sun

IPC: G02B21/00 ,  G01N21/51 ,  G01N33/58 ,  G02B21/02 ,  G02B21/10 ,  G02B21/26

CPC classification number: G02B21/0008 ,  G01N21/51 ,  G01N33/587 ,  G02B21/025 ,  G02B21/10 ,  G02B21/26 ,  G01N2201/0221

Abstract: A mobile phone-based dark field microscope (MDFM) apparatus suitable for quantifying nanoparticle signals is provided. The MDFM apparatus includes an electrically operated light source, a dark-field condenser, a slide housing configured to receive an analytical slide, and an adapter housing configured to receive an objective lens and receive a portable electronic communication device. The slide housing positions the analytical slide between the objective lens and the dark-field condenser. The adapter housing registers the objective lens with a camera lens of the portable electronic communication device. A method for performing a biological quantitative study using the dark-field microscope apparatus is further provided.

公开(公告)号：US20190234952A1

公开(公告)日：2019-08-01

申请号：US16211040

申请日：2018-12-05

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Ye Hu

IPC: G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57438 ,  G01N33/6848

Abstract: In certain embodiments, the present invention provides a method of detecting hypoxia status in a tumor cell by detecting a level of hydroxyprolyl BK (Hyp-BK) peptides in a patient sample, and detecting a level of bradykinin (BK) peptides the patient sample, wherein a change in the Hyp-BK/BK ratio as compared to the Hyp-BK/BK ratio in a comparable normal cell is a marker for tumor hypoxia.

公开(公告)号：US20190064178A1

公开(公告)日：2019-02-28

申请号：US16119100

申请日：2018-08-31

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  HOUSTON METHODIST

Inventor： Ye Hu ,  Yang Bu

IPC: G01N33/68 ,  C01G23/053 ,  C01G23/08

Abstract: Certain embodiments of the invention provide TiO2 nanoshell particles, methods of fabricating TiO2 nanoshell particles, and methods of enriching peptides in a sample using TiO2 nanoshell particles.