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公开(公告)号：US20220259226A1
公开(公告)日：2022-08-18
申请号：US17660355
申请日：2022-04-22
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Yujia Dai , Jane Gong , Roberto Risi , Yiyun Yu , Guidong Zhu
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20240228509A1
公开(公告)日：2024-07-11
申请号：US18365044
申请日：2023-08-03
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Andreas Kling , Frauke Pohlki , Jessee Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Michael Michaelides
IPC分类号： C07D495/16 , A61P35/00 , C07D519/00
CPC分类号： C07D495/16 , A61P35/00 , C07D519/00
摘要： The present disclosure provides for compounds of Formula (I)
wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).-
公开(公告)号：US20230399340A1
公开(公告)日：2023-12-14
申请号：US18046011
申请日：2022-10-12
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Andreas Kling , Frauke Pohlki , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Michael Michaelides
IPC分类号： C07D495/16 , A61P35/00 , C07D519/00
CPC分类号： C07D495/16 , A61P35/00 , C07D519/00
摘要： The present disclosure provides for compounds of Formula (I)
wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).-
4.发明申请公开(公告)号：US20200331907A1
公开(公告)日：2020-10-22
申请号：US16707777
申请日：2019-12-09
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496 , A61K45/06 , A61P37/00 , A61P35/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bc1-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
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公开(公告)号：US08686136B2
公开(公告)日：2014-04-01
申请号：US13712715
申请日：2012-12-12
申请人： AbbVie Inc.
发明人： Milan Bruncko , Hong Ding , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Xiaohong Song , Xilu Wang , Michael Wendt
IPC分类号： C07D241/04 , C07D403/02
CPC分类号： C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译： 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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6.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20150299197A1
公开(公告)日：2015-10-22
申请号：US14789449
申请日：2015-07-01
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06 , A61P35/00 , A61P37/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
摘要翻译： 本文公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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公开(公告)号：US20210403467A1
公开(公告)日：2021-12-30
申请号：US17167507
申请日：2021-02-04
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496 , A61K45/06 , A61P37/00 , A61P35/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
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8.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20170008891A1
公开(公告)日：2017-01-12
申请号：US15276872
申请日：2016-09-27
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
摘要翻译： 本文公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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9.发明申请公开(公告)号：US20180354952A1
公开(公告)日：2018-12-13
申请号：US16108346
申请日：2018-08-22
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06 , A61P35/00 , A61P37/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
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10.发明授权公开(公告)号：US10081628B2
公开(公告)日：2018-09-25
申请号：US15276872
申请日：2016-09-27
申请人： AbbVie Inc.
发明人： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06 , A61P35/00 , A61P37/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds. One embodiment of such compounds is 4-(4-{[2-(4-chloro-2-fluorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide.
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