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1.发明申请公开(公告)号：US20150137428A1
公开(公告)日：2015-05-21
申请号：US14597144
申请日：2015-01-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Kerek Mortisen , Xiao Ma , Fuh-Wei Tang , Byron Lambert
IPC: A61F2/82
CPC classification number: A61F2/82 , A61F2/0095 , A61F2240/001 , A61L2/081 , A61L2/082 , A61L2/087 , B29C71/009 , B29C71/04 , B29C2035/0877 , B65B55/16
Abstract: Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.
Abstract translation: 公开了电子束灭菌后稳定聚合物支架支架分子量的方法。 照射的支架的聚合物的分子量通过暴露于含氧气体而稳定。
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2.发明申请CONTROL OF DEGRADATION PROFILE OF BIOABSORBABLE POLY(L-LACTIDE) SCAFFOLD 审中-公开生物可溶性聚（L-柠檬酸）螯合物的降解特性的控制公开(公告)号：US20140353877A1
公开(公告)日：2014-12-04
申请号：US14460199
申请日：2014-08-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma
CPC classification number: A61L31/148 , A61L31/06 , A61L2430/00 , A61L2430/22 , B29C35/0288 , B29C35/0805 , B29C48/022 , B29C48/09 , B29C48/92 , B29C2035/0838 , B29C2948/92228 , B29C2948/92704 , B29K2067/046 , B29K2105/0002 , B29K2995/0088 , B29L2023/22 , B29L2031/7532 , C08L67/04
Abstract: Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. Disclosed methods include controlling features of the degradation profile including the time to loss of radial strength and the degradation time of the stent.
Abstract translation: 公开了控制可生物降解的支架支架的降解特征的方法。 所公开的方法包括控制降解曲线的特征，包括损失径向强度的时间和支架的降解时间。
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公开(公告)号：US20180154585A1
公开(公告)日：2018-06-07
申请号：US15828253
申请日：2017-11-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Rommel Lumauig
Abstract: A medical device includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen. A variable diameter sheath with a central portion that prevents expansion of the stent when the balloon is pressurized and larger diameter ends is disposed over the crimped stent-balloon assembly. The balloon is pressurized and the larger diameter ends of the sheath allow the balloon beyond the ends of the stent to expand. The balloon is then depressurized.
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公开(公告)号：US09750622B2
公开(公告)日：2017-09-05
申请号：US14307440
申请日：2014-06-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Xiao Ma , Mary Beth Kossuth , James P. Oberhauser , Stephen D. Pacetti , Manish Gada
CPC classification number: A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
Abstract: Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
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5.发明申请HIGH MOLECULAR WEIGHT POLYLACTIDE AND POLYCAPROLACTONE COPOLYMER AND BLENDS FOR BIORESORBABLE VASCULAR SCAFFOLDS 有权高分子量聚合物和聚碳酸酯共聚物和可生物降解血管的混合物公开(公告)号：US20150359648A1
公开(公告)日：2015-12-17
申请号：US14307440
申请日：2014-06-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Xiao Ma , Mary Beth Kossuth , James P. Oberhauser , Stephen D. Pacetti , Manish Gada
CPC classification number: A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
Abstract: Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
Abstract translation: 由具有高分子量聚合物的聚丙交酯和聚己内酯的组合制成的可生物再吸收的聚合物血管支架，在选定范围内的薄支柱和足够的径向强度以在部署时支撑血管。 支架具有有助于血管愈合的分子量，径向强度和质量的降解行为，包括向容器提供通畅性，降低径向强度，分解和再吸收以允许血管返回到自然状态。
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Patent Agency Ranking
公开(公告)号：US20150128527A1
公开(公告)日：2015-05-14
申请号：US14597119
申请日：2015-01-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Derek Mortisen , Xiao Ma , Fuh-Wei Tang , Byron Lambert
IPC: B65B55/16
CPC classification number: A61F2/82 , A61F2/0095 , A61F2240/001 , A61L2/081 , A61L2/082 , A61L2/087 , B29C71/009 , B29C71/04 , B29C2035/0877 , B65B55/16
Abstract: Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.
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公开(公告)号：US10278844B2
公开(公告)日：2019-05-07
申请号：US15688486
申请日：2017-08-28
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC: A61F2/915 , C08G63/08 , B29C71/02 , A61L31/06 , A61L31/14 , B29C71/00 , B29K67/00 , B29L31/00 , B29C35/04 , B29C35/08
Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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公开(公告)号：US09687594B2
公开(公告)日：2017-06-27
申请号：US14970890
申请日：2015-12-16
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , James Oberhauser
IPC: A61F2/06 , A61L31/14 , A61L31/06 , C08G63/08 , C08G63/90 , A61F2/89 , A61F2/82 , C08L67/04 , C09J167/04 , A61K9/20 , C09D167/04 , A61K9/16 , A61F2/958 , A61F2/30
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
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公开(公告)号：US09669137B2
公开(公告)日：2017-06-06
申请号：US14613304
申请日：2015-02-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Pacetti , Fuh-Wei Tang , Xiao Ma , Ni Ding , Derek Mortisen
IPC: A61F2/82 , A61K47/48 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/91 , A61L2/08 , B29C71/04 , C08G63/08 , B29B13/08 , B29C35/08 , A61F2/91
CPC classification number: A61L31/06 , A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61K47/593 , A61L2/087 , A61L31/10 , A61L31/148 , A61L2300/606 , B29B13/08 , B29C71/04 , B29C2035/0827 , B29C2035/085 , B29C2035/0877 , C08G63/08 , C08G63/912
Abstract: It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.
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公开(公告)号：US09566723B2
公开(公告)日：2017-02-14
申请号：US14139740
申请日：2013-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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