公开(公告)号：US06733172B2

公开(公告)日：2004-05-11

申请号：US10096788

申请日：2002-03-11

申请人： Abraham P. Lee ,  Asuncion V. Lemoff ,  Robin R. Miles

发明人： Abraham P. Lee ,  Asuncion V. Lemoff ,  Robin R. Miles

IPC分类号： B01F1308

CPC分类号： B01F13/0071 ,  B01F13/0064 ,  B01F13/0077 ,  B01F13/0094 ,  B01F2005/0017

摘要： A magnetohydrodynamic fluidic system mixes a first substance and a second substance. A first substrate section includes a first flow channel and a first plurality of pairs of spaced electrodes operatively connected to the first flow channel. A second substrate section includes a second flow channel and a second plurality of pairs of spaced electrodes operatively connected to the second flow channel. A third substrate section includes a third flow channel and a third plurality of pairs of spaced electrodes operatively connected to the third flow channel. A magnetic section and a control section are operatively connected to the spaced electrodes. The first substrate section, the second substrate section, the third substrate section, the first plurality of pairs of spaced electrodes, the second plurality of pairs of spaced electrodes, the third plurality of pairs of spaced electrodes, the magnetic section, and the control section are operated to move the first substance through the first flow channel, the second substance through the second flow channel, and both the first substance and the second substance into the third flow channel where they are mixed.

摘要翻译： 磁流体动力学流体系统混合第一物质和第二物质。 第一衬底部分包括第一流动通道和可操作地连接到第一流动通道的第一组多对间隔开的电极。 第二衬底部分包括可操作地连接到第二流动通道的第二流动通道和第二组成对的间隔开的电极。 第三衬底部分包括可操作地连接到第三流动通道的第三流动通道和第三组多对间隔开的电极。 磁性部分和控制部分可操作地连接到间隔开的电极。 第一基板部分，第二基板部分，第三基板部分，第一多对间隔电极，第二多对间隔电极，第三多对隔开的电极，磁性部分和控制部分 操作以使第一物质通过第一流动通道，第二物质通过第二流动通道，以及第一物质和第二物质两者进入混合的第三流动通道。

公开(公告)号：US06576459B2

公开(公告)日：2003-06-10

申请号：US09815624

申请日：2001-03-23

申请人： Robin R. Miles ,  Amy W. Wang ,  Christopher K. Fuller ,  Asuncion V. Lemoff ,  Kerry A. Bettencourt ,  June Yu

发明人： Robin R. Miles ,  Amy W. Wang ,  Christopher K. Fuller ,  Asuncion V. Lemoff ,  Kerry A. Bettencourt ,  June Yu

IPC分类号： C12M136

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0076 ,  B01L7/52 ,  B01L2200/10 ,  B01L2400/0424 ,  B01L2400/043 ,  G01N1/4077 ,  G01N15/0656 ,  G01N2015/0088 ,  Y10S435/81 ,  Y10S435/962

摘要： A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.

公开(公告)号：US6146103A

公开(公告)日：2000-11-14

申请号：US170614

申请日：1998-10-09

申请人： Abraham P. Lee ,  Asuncion V. Lemoff

发明人： Abraham P. Lee ,  Asuncion V. Lemoff

IPC分类号： B01F13/00 ,  B01L3/00 ,  F04B19/00 ,  F15C5/00 ,  F16K99/00 ,  H02K44/04 ,  H02K44/02

CPC分类号： B01F13/0077 ,  B01L3/50273 ,  B01L3/502738 ,  F04B19/006 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0046 ,  H02K44/04 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0655 ,  B01L3/502784 ,  F16K2099/0074

摘要： A magnetohydrodynamic (MHD) micropump and microsensor which utilizes micromachining to integrate the electrodes with microchannels and includes a magnet for producing magnetic fields perpendicular to both the electrical current direction and the fluid flow direction. The magnet can also be micromachined and integrated with the micropump using existing technology. The MHD micropump, for example, can generate continuous, reversible flow, with readily controllable flow rates. The flow can be reversed by either reversing the electrical current flow or reversing the magnetic field. By mismatching the electrodes, a swirling vortex flow can be generated for potential mixing applications. No moving parts are necessary and the dead volume is minimal. The micropumps can be placed at any position in a fluidic circuit and a combination of micropumps can generate fluidic plugs and valves.

摘要翻译： 磁流体动力学（MHD）微型泵和微传感器，其利用微机械加工将电极与微通道集成，并且包括用于产生垂直于电流方向和流体流动方向的磁场的磁体。 磁体也可以使用现有技术进行微加工和与微型泵集成。 例如，MHD微型泵可以产生具有容易控制的流速的连续可逆流。 可以通过反转电流或反转磁场来逆流。 通过使电极不匹配，可以产生涡流涡流用于潜在的混合应用。 不需要移动部件，死体积最小。 微型泵可以放置在流体回路中的任何位置，并且微型泵的组合可以产生流体塞和阀。

公开(公告)号：US07753656B2

公开(公告)日：2010-07-13

申请号：US10176942

申请日：2002-06-20

申请人： Asuncion V. Lemoff ,  Abraham P. Lee

发明人： Asuncion V. Lemoff ,  Abraham P. Lee

IPC分类号： H02K44/00 ,  H02K44/08

CPC分类号： H02K44/04

摘要： A magnetohydrodynamic pump for pumping a fluid. The pump includes a microfluidic channel for channeling the fluid, a MHD electrode/magnet system operatively connected to the microfluidic channel, and a system for promoting flow of the fluid in one direction in the microfluidic channel. The pump has uses in the medical and biotechnology industries for blood-cell-separation equipment, biochemical assays, chemical synthesis, genetic analysis, drug screening, an array of antigen-antibody reactions, combinatorial chemistry, drug testing, medical and biological diagnostics, and combinatorial chemistry. The pump also has uses in electrochromatography, surface micromachining, laser ablation, inkjet printers, and mechanical micromilling.

摘要翻译： 用于泵送流体的磁流体动力泵。 泵包括用于引导流体的微流体通道，可操作地连接到微流体通道的MHD电极/磁体系统，以及用于促进流体在微流体通道中的一个方向流动的系统。 该泵在医疗和生物技术行业用于血细胞分离设备，生物化学测定，化学合成，遗传分析，药物筛选，抗原 - 抗体反应阵列，组合化学，药物测试，医学和生物诊断以及 组合化学。 该泵还用于电色谱，表面微加工，激光烧蚀，喷墨打印机和机械微型加工。