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公开(公告)号：US11180463B2
公开(公告)日：2021-11-23
申请号：US16382539
申请日：2019-04-12
发明人： Song Li , Wu Zhong , Shuang Cao , Lili Wang , Zhibing Zheng , Junhai Xiao , Xinbo Zhou
IPC分类号： C07D277/22 , A61K31/426 , C07D277/30 , A61K8/49 , A61K31/4422 , A61Q11/00 , A61Q19/08
摘要： The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development.
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公开(公告)号：US10301279B2
公开(公告)日：2019-05-28
申请号：US15794666
申请日：2017-10-26
发明人： Wu Zhong , Song Li , Yanqun Zeng , Junhai Xiao , Xinbo Zhou , Zhibing Zheng , Xingzhou Li , Xiaokui Wang
IPC分类号： A61K31/506 , C07D401/04 , C07D401/14 , C07D409/14 , A61K45/06 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K31/517 , A61K31/5377
摘要： The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
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公开(公告)号：US10196411B2
公开(公告)日：2019-02-05
申请号：US15539266
申请日：2015-12-11
发明人： Song Li , Xingzhou Li , Wu Zhong , Zhibing Zheng , Junhai Xiao , Xinbo Zhou , Yunde Xie , Xiaokui Wang , Lili Wang , Wei Chen , Fei Xie
IPC分类号： C07D277/58 , C07F9/6539 , A61K31/426 , A61K31/675 , A61P31/20 , A61P31/14 , A61P31/16 , A61P31/06 , A61P33/02 , A61P33/04 , A61P33/10 , A61P1/00
摘要： The invention relates to tizoxanide phosphate or alkane sulfonate compounds represented by Formula I, and pharmaceutically acceptable salts thereof, isomers thereof, hydrates thereof or solvates thereof, and pharmaceutical applications of the compounds.
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公开(公告)号：US09630957B2
公开(公告)日：2017-04-25
申请号：US14893391
申请日：2014-05-28
发明人： Song Li , Junhai Xiao , Xian Zhang , Wu Zhong , Zhibing Zheng , Lili Wang , Yunde Xie , Xingzhou Li , Xinbo Zhou , Xiaokui Wang
IPC分类号： C07D417/12 , C07D303/48 , C07D417/14
CPC分类号： C07D417/12 , C07D303/48 , C07D417/14
摘要： Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.
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![(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof](/abs-image/US/2016/12/13/US09518008B2/abs.jpg.150x150.jpg)
5.发明授权(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof 有权（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4- uan基-2-羟基 - 环戊基-1-羧酸水合物公开(公告)号：US09518008B2
公开(公告)日：2016-12-13
申请号：US14511783
申请日：2014-10-10
发明人： Song Li , Wu Zhong , Zhibing Zheng , Xinbo Zhou , Junhai Xiao , Yunde Xie , Lili Wang , Xingzhou Li , Guoming Zhao , Xiaokui Wang , Hongying Liu
IPC分类号： A61K31/196 , C07C279/16 , C07C277/08 , A61P31/16 , C07C277/06
CPC分类号： C07C279/16 , C07B2200/07 , C07C277/06 , C07C277/08 , C07C2601/08
摘要： The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.
摘要翻译： 本发明涉及（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物， 其制备方法，含有所述化合物的药物组合物及其制备方法，以及所述化合物作为抗流感病毒的神经脒酶抑制剂的临床应用。
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![(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof](/abs-image/US/2016/03/01/US09272992B2/abs.jpg.150x150.jpg)
6.发明授权(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof 有权（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物公开(公告)号：US09272992B2
公开(公告)日：2016-03-01
申请号：US13968645
申请日：2013-08-16
发明人： Song Li , Wu Zhong , Zhibing Zheng , Xinbo Zhou , Junhai Xiao , Yunde Xie , Lili Wang , Xingzhou Li , Guoming Zhao , Xiaokui Wang , Hongying Liu
IPC分类号： A61K31/24 , A01N37/12 , A01N37/44 , C07C279/16 , C07C277/06 , C07C277/08
CPC分类号： C07C279/16 , C07B2200/07 , C07C277/06 , C07C277/08 , C07C2601/08
摘要： The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.
摘要翻译： 本发明涉及（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物， 其制备方法，含有所述化合物的药物组合物及其制备方法，以及所述化合物作为抗流感病毒的神经脒酶抑制剂的临床应用。
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公开(公告)号：US11447463B2
公开(公告)日：2022-09-20
申请号：US16379413
申请日：2019-04-09
发明人： Wu Zhong , Song Li , Yanqun Zeng , Junhai Xiao , Xinbo Zhou , Zhibing Zheng , Xingzhou Li , Xiaokui Wang
IPC分类号： A61K45/06 , C07D401/04 , C07D401/14 , A61K31/506 , C07D409/14 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K31/517 , A61K31/5377
摘要： The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
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8.发明授权公开(公告)号：US10759822B2
公开(公告)日：2020-09-01
申请号：US16093754
申请日：2017-04-11
发明人： Song Li , Xinbo Zhou , Dian Xiao , Wu Zhong , Junhai Xiao , Zhibing Zheng , Xingzhou Li , Yunde Xie , Xiaokui Wang
IPC分类号： C07H13/04 , C07D413/12 , C07D271/12 , A61P11/00 , A61P25/28 , C07H1/00 , A61K31/7056 , A61K31/4245
摘要： Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.
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公开(公告)号：US10335417B2
公开(公告)日：2019-07-02
申请号：US15739872
申请日：2016-06-28
发明人： Song Li , Junhai Xiao , Boqun Lyu , Hongqiang Wang , Wu Zhong , Lili Wang , Zhibing Zheng , Yunde Xie , Xinbo Zhou , Xingzhou Li , Xiaokui Wang
IPC分类号： C07D279/12 , A61K31/54 , A61P25/28 , A61P25/16
摘要： The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.
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公开(公告)号：US10071994B2
公开(公告)日：2018-09-11
申请号：US15314888
申请日：2015-05-25
发明人： Song Li , Junhai Xiao , Qi Sun , Wu Zhong , Lili Wang , Zhibing Zheng , Yunde Xie , Xingzhou Li , Xinbo Zhou , Xiaokui Wang , Ruiyuan Cao
IPC分类号： C07D307/33 , A61K31/341 , C07D409/12 , A61K31/381 , A61K45/06 , C07D407/12 , C12Q1/02 , C07D405/12 , A61K31/4025 , A61K31/365
CPC分类号： C07D409/12 , A61K31/34 , A61K31/365 , A61K31/381 , A61K31/4025 , A61K45/06 , C07D307/33 , C07D405/00 , C07D405/12 , C07D407/12 , C12Q1/025 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium
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