公开(公告)号：US20230218549A1

公开(公告)日：2023-07-13

申请号：US17817927

申请日：2022-08-05

申请人： Acucela Inc.

发明人： Ian L. SCOTT ,  Vladimir A. KUKSA ,  Mark W. ORME ,  Thomas L. LITTLE, JR. ,  Anna GALL ,  Feng HONG

IPC分类号： A61K31/137 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06 ,  C07C217/20 ,  C07C215/20 ,  C07C309/06 ,  C07C217/84 ,  C07C323/33 ,  A61K31/165 ,  A61K31/222

CPC分类号： A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07D277/24 ,  C07D309/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42

摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.

公开(公告)号：US20190183816A1

公开(公告)日：2019-06-20

申请号：US16043019

申请日：2018-07-23

申请人： Acucela Inc.

发明人： Ian L. SCOTT ,  Vladimir A. KUKSA ,  Mark W. ORME ,  Thomas L. LITTLE, JR. ,  Anna GALL ,  Feng HONG

IPC分类号： A61K31/137 ,  C07C317/28 ,  C07C217/84 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  A61K31/222 ,  A61K31/165 ,  C07C323/33 ,  C07C215/20 ,  C07D309/06 ,  C07D277/24 ,  C07C323/25 ,  C07C309/06 ,  C07C279/08 ,  C07C251/86 ,  C07C235/08 ,  C07C233/18 ,  C07C229/38 ,  C07C225/16 ,  C07C217/72

CPC分类号： A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.