公开(公告)号：US20230218549A1

公开(公告)日：2023-07-13

申请号：US17817927

申请日：2022-08-05

Applicant: Acucela Inc.

Inventor： Ian L. SCOTT ,  Vladimir A. KUKSA ,  Mark W. ORME ,  Thomas L. LITTLE, JR. ,  Anna GALL ,  Feng HONG

IPC: A61K31/137 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06 ,  C07C217/20 ,  C07C215/20 ,  C07C309/06 ,  C07C217/84 ,  C07C323/33 ,  A61K31/165 ,  A61K31/222

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07D277/24 ,  C07D309/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.

公开(公告)号：US20210077427A1

公开(公告)日：2021-03-18

申请号：US16865195

申请日：2020-05-01

Applicant: Acucela Inc.

Inventor： Ian L. SCOTT ,  Vladimir A. KUKSA ,  Mark W. ORME ,  Thomas L. LITTLE, Jr. ,  Anna GALL ,  Feng HONG

IPC: A61K31/137 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06 ,  C07C217/20 ,  C07C215/20 ,  C07C309/06 ,  C07C217/84 ,  C07C323/33 ,  A61K31/165 ,  A61K31/222

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US20160145198A1

公开(公告)日：2016-05-26

申请号：US14946721

申请日：2015-11-19

Applicant: Acucela Inc.

Inventor： Ian L. SCOTT ,  Vladimir A. KUKSA ,  Feng HONG ,  Ryo KUBOTA ,  Jennifer GAGE

IPC: C07C233/25 ,  C07C225/06 ,  C07C215/08

CPC classification number: C07C233/25 ,  A61K31/167 ,  A61K31/18 ,  C07B59/001 ,  C07B2200/05 ,  C07C211/49 ,  C07C211/52 ,  C07C215/08 ,  C07C215/14 ,  C07C215/42 ,  C07C215/68 ,  C07C217/08 ,  C07C217/10 ,  C07C217/58 ,  C07C225/06 ,  C07C225/22 ,  C07C233/36 ,  C07C233/43 ,  C07C233/62 ,  C07C275/40 ,  C07C311/08 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/24 ,  C07C335/18 ,  C07C2601/08 ,  C07C2601/14 ,  C07D277/28

Abstract: Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Abstract translation: 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。

公开(公告)号：US20190183816A1

公开(公告)日：2019-06-20

申请号：US16043019

申请日：2018-07-23

Applicant: Acucela Inc.

Inventor： Ian L. SCOTT ,  Vladimir A. KUKSA ,  Mark W. ORME ,  Thomas L. LITTLE, JR. ,  Anna GALL ,  Feng HONG

IPC: A61K31/137 ,  C07C317/28 ,  C07C217/84 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  A61K31/222 ,  A61K31/165 ,  C07C323/33 ,  C07C215/20 ,  C07D309/06 ,  C07D277/24 ,  C07C323/25 ,  C07C309/06 ,  C07C279/08 ,  C07C251/86 ,  C07C235/08 ,  C07C233/18 ,  C07C229/38 ,  C07C225/16 ,  C07C217/72

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.