Strain-Independent Amplification of Pathogens and Vaccines Thereto
    5.
    发明申请
    Strain-Independent Amplification of Pathogens and Vaccines Thereto 有权
    病原菌和疫苗的应变无关扩增

    公开(公告)号:US20080311155A1

    公开(公告)日:2008-12-18

    申请号:US11662828

    申请日:2005-09-14

    摘要: This in invention relates to methods for the nucleic acid amplification of multiple variants (strains) of any pathogen present in a sample, and preferably in a sample from a pathogen infected individual. In preferred embodiments, the pathogen is a retrovirus, such as HIV. The amplified pathogen nucleic acid can be used to identify the pathogen variants present in a sample, to quantitate the pathogen present in a sample, and as a nucleic acid vaccine, or in the preparation of antigen presenting cell vaccines. Nucleic acids produced by the methods of the invention or the proteins encoded thereby can be used to transfect/load antigen presenting cells. The loaded antigen presenting cells can then be used as a vaccine for the treatment of pathogen infection. In another embodiment, nucleic acids produced by the methods of the invention can be used directly as nucleic acid vaccines without prior loading into antigen presenting cells.

    摘要翻译: 本发明涉及用于核酸扩增样品中存在的任何病原体的多种变体(菌株)的方法,优选来自病原体感染个体的样品。 在优选的实施方案中,病原体是逆转录病毒,例如HIV。 扩增的病原体核酸可用于鉴定样品中存在的病原体变体,以定量样品中存在的病原体,以及作为核酸疫苗或制备抗原呈递细胞疫苗。 通过本发明的方法产生的核酸或由其编码的蛋白质可用于转染/负载抗原呈递细胞。 然后将负载的抗原呈递细胞用作用于治疗病原体感染的疫苗。 在另一个实施方案中,通过本发明的方法产生的核酸可以直接用作核酸疫苗而不预先加载到抗原呈递细胞中。

    WELLBORE COMMUNICATION SYSTEM AND METHOD
    6.
    发明申请
    WELLBORE COMMUNICATION SYSTEM AND METHOD 审中-公开
    井沟通信系统和方法

    公开(公告)号:US20070168132A1

    公开(公告)日:2007-07-19

    申请号:US11278712

    申请日:2006-04-05

    IPC分类号: G01V1/40 G01V3/18 G06F19/00

    CPC分类号: E21B47/12

    摘要: A communication system is used to download data from a downhole tool. The system includes at least one removable memory unit positioned in the downhole tool, at least one surface computer for receiving data from the at least one memory unit and a communication link for transmitting data from the memory unit to the surface computer. The communication link may be a direct, hard-wired, wireless or optical link.

    摘要翻译: 通信系统用于从井下工具下载数据。 该系统包括位于井下工具中的至少一个可移除存储器单元,用于从至少一个存储器单元接收数据的至少一个表面计算机和用于将数据从存储器单元传输到表面计算机的通信链路。 通信链路可以是直接的,硬连线的,无线的或光链路。

    Image server synchronization
    8.
    发明授权
    Image server synchronization 失效
    图像服务器同步

    公开(公告)号:US06938045B2

    公开(公告)日:2005-08-30

    申请号:US10051337

    申请日:2002-01-18

    IPC分类号: G06F12/00 G06F17/30 G06G17/30

    摘要: A package of local files are maintained in a first local computing device and a descriptive record of the local files is maintained in a second local computing device. A directory-modified-date parameter within the first local computing device and a file-modified-date parameter in the second local computing device, but updated in accordance with a local clock from the first local computing device, are used to maintain the descriptive record in the second local computing device synchronized with changes to the local files in the first local computing device. Copies of the descriptive record and package of local files are maintained in a remote computing system. A first package-modified-date, PMD, parameter in the second local computing device and a second PMD parameter in the remote computing system are used to maintain the copies in the remote computing system synchronized with those in first and second local computing devices.

    摘要翻译: 一组本地文件被维护在第一本地计算设备中,并且本地文件的描述性记录被维护在第二本地计算设备中。 第一本地计算设备内的目录修改日期参数和第二本地计算设备中的文件修改日期参数,但是根据来自第一本地计算设备的本地时钟更新的参数被用于维护描述性记录 在第二本地计算设备中与第一本地计算设备中的本地文件的改变同步。 在远程计算系统中维护本地文件的描述性记录和包的副本。 使用第二本地计算设备中的第一包修改日期PMD参数和远程计算系统中的第二PMD参数来维护远程计算系统中的副本与第一和第二本地计算设备中的副本同步。

    Spin-top candy dispenser
    10.
    发明授权
    Spin-top candy dispenser 失效
    旋转糖果机

    公开(公告)号:US06401970B1

    公开(公告)日:2002-06-11

    申请号:US09690518

    申请日:2000-10-17

    IPC分类号: A24F1504

    CPC分类号: A63H1/16 A63H1/20 B65D83/0409

    摘要: A candy dispenser may be provided with a housing having a candy reservoir formed therein in which a plurality of pieces of candy may be disposed, a spin top having a downwardly extending member that is centrally located on the spin top to facilitate spinning of the spin top while the downwardly extending member supports the spin top, a candy dispensing mechanism including a candy dispensing opening that allows a piece of candy to be dispensed from the candy reservoir, and an actuator associated with the spin top and the candy dispensing mechanism. The actuator may be movable to a first position and to a second position, with movement of the actuator to the first position causing the spin top to be launched from the housing so that the spin top may land on a surface and spin on its downwardly extending member, and with movement of the actuator to the second position causing one of the pieces of candy to be dispensed through the dispensing opening.

    摘要翻译: 糖果分配器可以设置有具有形成在其中的糖果储存器的壳体,其中可以设置多个糖果块,旋转顶部具有位于旋转顶部中心的向下延伸的构件,以促进旋转顶部的旋转 而向下延伸的构件支撑旋转顶部,糖果分配机构包括糖果分配开口,其允许从糖果储存器分配一块糖果,以及与旋转顶部和糖果分配机构相关联的致动器。 致动器可以可移动到第一位置和第二位置,随着致动器移动到第一位置,使得旋转顶部从壳体发射,使得旋转顶部可以落在表面上并且旋转在其向下延伸的 并且随着致动器的运动到第二位置,导致通过分配开口分配糖果之一。