公开(公告)号：US20100228280A1

公开(公告)日：2010-09-09

申请号：US12400041

申请日：2009-03-09

申请人： Adam Groothuis ,  Edward I. McNamara ,  Peter Markham ,  Elazer R. Edelman

发明人： Adam Groothuis ,  Edward I. McNamara ,  Peter Markham ,  Elazer R. Edelman

IPC分类号： A61M29/02 ,  A61M25/10 ,  A61F2/01

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0078 ,  A61M25/0074 ,  A61M25/0082 ,  A61M25/1011 ,  A61M25/104 ,  A61M2025/0096 ,  A61M2025/109 ,  A61M2025/1093

摘要： The invention provides a variety of catheters and methods for using such catheters. An exemplary catheter includes an elongate body having a proximal end a distal end. The elongate body defines a longitudinal axis of the catheter. The exemplary catheter further includes at least one inflatable member disposed on the elongate body proximate the distal end of the elongate body. The interior of the inflatable member is in fluid communication with an inflation lumen in the elongate body. The exemplary catheter also includes a first filter adapted and configured to capture emboli in a patient's bloodstream as the bloodstream passes through the first filter along a first direction. The exemplary catheter further includes a second filter adapted and configured to capture emboli in a patient's bloodstream as the bloodstream passes through the second filter along a second direction, wherein the second direction is generally opposite to the first direction.

摘要翻译： 本发明提供了使用这种导管的各种导管和方法。 示例性导管包括具有近端远端的细长体。 细长体限定导管的纵向轴线。 示例性导管还包括至少一个可伸缩构件，该可膨胀构件设置在细长主体上，靠近细长主体的远端。 可膨胀构件的内部与细长体中的充气腔流体连通。 示例性导管还包括适于并配置为当血流沿着第一方向通过第一过滤器时将栓塞捕获在患者血流中的第一过滤器。 示例性导管进一步包括第二过滤器，其适于并配置成当血流沿着第二方向通过第二过滤器时将栓塞捕获在患者的血流中，其中第二方向通常与第一方向相反。

公开(公告)号：US10022222B2

公开(公告)日：2018-07-17

申请号：US12899231

申请日：2010-10-06

申请人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer R. Edelman

发明人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer R. Edelman

IPC分类号： A61F2/24

摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

公开(公告)号：US20110112630A1

公开(公告)日：2011-05-12

申请号：US12899231

申请日：2010-10-06

申请人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer R. Edelman

发明人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer R. Edelman

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2463 ,  A61F2/2475

摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

摘要翻译： 本实施例涉及用于治疗腔内瓣膜的系统和方法。 特别地，根据一个方面，本公开涉及用于部分或完全更换管腔瓣膜的方法和系统。 根据本公开的示例性导管包括具有近端和远端的细长主体，以及靠近远端安装在细长主体上的可伸缩护套。 鞘和细长体配合以在主体和鞘之间限定第一环形形状的隔室。 导管还包括安装在隔室中的瓣膜假体，假体具有近端和远端连接到用于从导管展开瓣膜假体的装置。

公开(公告)号：US20130310924A1

公开(公告)日：2013-11-21

申请号：US13868226

申请日：2013-04-23

申请人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

发明人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2463 ,  A61F2/2475

摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

摘要翻译： 本实施例涉及用于治疗腔内瓣膜的系统和方法。 特别地，根据一个方面，本公开涉及用于部分或完全更换管腔瓣膜的方法和系统。 根据本公开的示例性导管包括具有近端和远端的细长主体，以及靠近远端安装在细长主体上的可伸缩护套。 鞘和细长体配合以在主体和鞘之间限定第一环形形状的隔室。 导管还包括安装在隔室中的瓣膜假体，假体具有近端和远端连接到用于从导管展开瓣膜假体的装置。

公开(公告)号：US20190060070A1

公开(公告)日：2019-02-28

申请号：US16036618

申请日：2018-07-16

申请人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

发明人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

IPC分类号： A61F2/24

摘要： A partial valve prosthesis includes a framework configured for following a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including securement features for anchoring the framework to an inner periphery of the native valve annulus and retaining at least one leaflet configured to replace a corresponding one of the plurality of native leaflets; and at least one leaflet secured to the framework. Additional embodiments and methods are disclosed.

公开(公告)号：US20210015615A1

公开(公告)日：2021-01-21

申请号：US16943606

申请日：2020-07-30

申请人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

发明人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

IPC分类号： A61F2/24

摘要： A partial valve prosthesis includes a framework configured for following a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including securement features for anchoring the framework to an inner periphery of the native valve annulus and retaining at least one leaflet configured to replace a corresponding one of the plurality of native leaflets; and at least one leaflet secured to the framework. Additional embodiments and methods are disclosed.

公开(公告)号：US08894704B2

公开(公告)日：2014-11-25

申请号：US13868226

申请日：2013-04-23

申请人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

发明人： Adam Groothuis ,  Adrian Ebner ,  Peter Markham ,  Elazer Edelman

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2463 ,  A61F2/2475

摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

摘要翻译： 本实施例涉及用于治疗腔内瓣膜的系统和方法。 特别地，根据一个方面，本公开涉及用于部分或完全更换管腔瓣膜的方法和系统。 根据本公开的示例性导管包括具有近端和远端的细长主体，以及靠近远端安装在细长主体上的可伸缩护套。 鞘和细长体配合以在主体和鞘之间限定第一环形形状的隔室。 导管还包括安装在隔室中的瓣膜假体，假体具有近端和远端连接到用于从导管展开瓣膜假体的装置。

公开(公告)号：US08226709B2

公开(公告)日：2012-07-24

申请号：US12249388

申请日：2008-10-10

申请人： Adam Groothuis ,  Matthew Krever ,  Timothy Lash ,  Rudolph Cedro ,  Ted Bachman ,  Paul D'Antonio ,  Erin Black ,  Daniel H. Olsen ,  Salvatore G. Caldarise ,  Natalie D. Macon ,  Paritosh Dhawale

发明人： Adam Groothuis ,  Matthew Krever ,  Timothy Lash ,  Rudolph Cedro ,  Ted Bachman ,  Paul D'Antonio ,  Erin Black ,  Daniel H. Olsen ,  Salvatore G. Caldarise ,  Natalie D. Macon ,  Paritosh Dhawale

IPC分类号： A61F2/24 ,  A61B17/10

CPC分类号： A61F2/2466 ,  A61B17/00234 ,  A61B17/29 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/2905 ,  A61B2017/2923 ,  A61B2017/2925 ,  A61B2017/2927 ,  A61B2017/2939 ,  A61B2017/2946

摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.

摘要翻译： 描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。 该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。 第一个是具有可脱垂或弯曲的尖端的交叉导管。 第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。 第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。 第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。 经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。

公开(公告)号：US20070093857A1

公开(公告)日：2007-04-26

申请号：US11586201

申请日：2006-10-25

申请人： Campbell Rogers ,  Adam Groothuis

发明人： Campbell Rogers ,  Adam Groothuis

IPC分类号： A61B17/10

CPC分类号： A61B17/0644 ,  A61B17/068 ,  A61B17/08 ,  A61B17/10 ,  A61B17/1285 ,  A61B2017/00243

摘要： A medical device, method and system of treating the lumenal system of a patient are provided. The medical device includes a tissue plicator adapted and configured to form a plication of tissue proximate a target region of a patient. The medical device further includes a retainer applicator operatively associated with the tissue plicator. The retainer applicator is adapted and configured to apply a retainer to the plication to maintain the plication after the medical device is removed from the patient. In accordance with a further aspect, the tissue plicator may plicate tissue by mechanically clamping the tissue and/or may plicate the tissue at least in part by applying suction thereto. The system can be used to plicate tissue proximate the mitral valve of a patient. The plication can be formed temporarily or permanently.

摘要翻译： 提供了一种治疗患者的腔内系统的医疗装置，方法和系统。 医疗装置包括适于并构造为在患者的目标区域附近形成组织的褶皱的组织矫正器。 医疗装置还包括与组织矫正器可操作地相关联的保持器施加器。 保持器施加器被适配和构造成在将医疗装置从病人身上移开之后，将保持器施加到折片以维持折痕。 根据另一方面，组织矫正器可以通过机械地夹紧组织和/或可以至少部分地通过向其施加吸力而使组织折叠组织。 该系统可用于在患者的二尖瓣附近折叠组织。 可以暂时或永久地形成折射。

公开(公告)号：US06994718B2

公开(公告)日：2006-02-07

申请号：US10694944

申请日：2003-10-29

申请人： Adam Groothuis ,  Jack Pryor

发明人： Adam Groothuis ,  Jack Pryor

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61B17/12109 ,  A61B17/12136 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071 ,  A61F2230/0076

摘要： An elongate distal protection device includes an intraluminal filter-occluder combination positioned at a distal end thereof. An expandable occluder is disposed within an expandable filter such that the filter and occluder are independently deployable. During use, the expanded occluder may be used first to stop embolic particles for aspiration thereof. Then, the occluder may be collapsed, leaving the filter expanded to capture any remaining embolic particles.

摘要翻译： 细长远端保护装置包括位于其远端的管腔内过滤器 - 封堵器组合。 可膨胀封堵器设置在可扩张过滤器内，使得过滤器和封堵器可独立展开。 在使用期间，可以首先使用扩张的闭塞器来阻止栓塞颗粒吸入。 然后，闭塞器可能被塌缩，使得过滤器膨胀以捕获任何剩余的栓塞颗粒。