公开(公告)号：US20160195492A1

公开(公告)日：2016-07-07

申请号：US14987352

申请日：2016-01-04

Applicant: Advanced Liquid Logic, Inc.

Inventor： William Craig Bauer

IPC: G01N27/447 ,  B01L7/00 ,  B01L3/00

CPC classification number: G01N27/44734 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L7/525 ,  B01L7/54 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0677 ,  B01L2400/0683 ,  G01N27/44791

Abstract: The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.

公开(公告)号：US20140231257A1

公开(公告)日：2014-08-21

申请号：US14234855

申请日：2012-07-25

Applicant: ADVANCED LIQUID LOGIC, INC.

Inventor： William Craig Bauer ,  Ramakrishna Sista ,  Donovan E. Bort

IPC: C02F1/40 ,  B23P11/02 ,  G01N27/00

CPC classification number: B01L3/502715 ,  B01L3/502792 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/0427 ,  B01L2400/043 ,  B23P11/02 ,  Y10T29/49945

Abstract: Droplet actuator apparatus and system are provided. An apparatus comprises: a microfluidics system having an insertion slot for insertion of a droplet actuator; a bottom plate against which the droplet actuator would slide when inserting the droplet actuator into the insertion slot; and means for forcing a substrate in the droplet actuator parallel to the bottom plate, wherein warpage in the substrate is corrected.

Abstract translation: 提供液滴致动器装置和系统。 一种装置包括：具有用于插入液滴致动器的插入口的微流体系统; 当将液滴致动器插入插槽时液滴致动器将滑动的底板; 以及用于强制平行于底板的液滴致动器中的基板的装置，其中校正基板中的翘曲。

公开(公告)号：US09910010B2

公开(公告)日：2018-03-06

申请号：US14987352

申请日：2016-01-04

Applicant: Advanced Liquid Logic, Inc.

Inventor： William Craig Bauer

IPC: G01N27/447 ,  B01L7/00 ,  B01L3/00 ,  B01F13/00

CPC classification number: G01N27/44734 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502784 ,  B01L7/525 ,  B01L7/54 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0677 ,  B01L2400/0683 ,  G01N27/44791

Abstract: The invention relates to a droplet actuator device and methods for integrated sample preparation and analysis of a biological sample. A droplet actuator device is provided for conducting droplet operations. The droplet actuator device may include a bottom substrate and a top substrate separated from each other to form a gap therebetween; an arrangement of droplet operations electrodes arranged on one or both of the bottom and/or top substrates for conducting droplet operations thereon; a reagent storage layer comprising one or more compartments bound to the top substrate; and one or more openings arranged to provide a fluidic path from the one or more compartments into the gap, upon breach of a breachable seal separating the one or more compartments and openings.