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公开(公告)号：US09223317B2
公开(公告)日：2015-12-29
申请号：US13915842
申请日：2013-06-12
Applicant: Advanced Liquid Logic Inc.
Inventor： Theodore Winger
CPC classification number: G05D7/0629 , B01L3/0268 , B01L3/502707 , B01L3/502784 , B01L7/52 , B01L2200/0668 , B01L2300/0681 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2300/161 , B01L2300/165 , B01L2400/0427 , B01L2400/043 , Y10T137/0318 , Y10T137/206
Abstract: Droplet actuators that include molecular barrier coatings are provided. The molecular barrier coating may be provided atop the conductive layer of the top substrate, atop the droplet operations electrodes of the bottom substrate, or both. Where the conductive layer of the top substrate and/or the droplet operations electrodes of the bottom substrate are formed of an electrically conductive organic polymer, such as poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS), the molecular barrier coating helps to immobilize the contents of the PEDOT:PSS layer. Further, the molecular barrier coating reduces, preferably entirely eliminates, moisture from seeping into the electrically conducting organic polymer. Methods of conducting droplet operations using the disclosed droplet actuators are also provided.
Abstract translation: 提供了包括分子阻隔涂层的液滴致动器。 分子屏障涂层可以设置在顶部基底的导电层顶部，位于底部基底的液滴操作电极顶部，或两者之上。 在顶部基板的导电层和/或底部基板的液滴操作电极由诸如聚（3,4-亚乙基二氧噻吩）聚（苯乙烯磺酸盐）（PEDOT：PSS）的导电有机聚合物形成的情况下，分子 阻隔涂层有助于固定PEDOT：PSS层的内容物。 此外，分子阻隔涂层减少，优选完全消除水分渗透到导电有机聚合物中。 还提供了使用所公开的液滴致动器进行液滴操作的方法。
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公开(公告)号：US09574220B2
公开(公告)日：2017-02-21
申请号：US14644989
申请日：2015-03-11
Applicant: Advanced Liquid Logic, Inc.
Inventor： Allen E Eckhardt , Carrie Graham , Ramakrishna Sista , Vamsee K. Pamula , Theodore Winger , Tong Wang , Yalin Xiong , Ning Wu , Sanjay Saha , Gajendrasinh Raolji , Raveendra Dayam
IPC: C12Q1/54 , C12Q1/34 , C07D311/18 , C07D311/20 , C07H15/203 , C12Q1/25 , G01N33/543 , G01N21/64 , C07D311/16 , C07D405/12 , C07D413/12 , C07H17/075 , C12Q1/44 , B01L3/00
CPC classification number: C12Q1/40 , B01L3/502784 , B01L2300/0654 , B01L2300/0816 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07D311/16 , C07D311/18 , C07D311/20 , C07D405/12 , C07D413/12 , C07H15/203 , C07H17/075 , C12Q1/25 , C12Q1/34 , C12Q1/44 , C12Q1/54 , C12Y302/01023 , G01N21/6452 , G01N33/5438 , G01N2333/916 , G01N2333/926 , G01N2333/938 , G01N2800/04
Abstract: The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.
Abstract translation: 本发明涉及液滴致动器装置和测定方法。 本发明包括进行测定的测定方法，其包括将样品与伞形酮基衍生物组合，其中所述样品潜在地包含能够切割伞形变体基衍生物的酶，并且其中伞形载体衍生物包含用一个或多个修饰部分修饰的伞形酮核心。
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公开(公告)号：US09545641B2
公开(公告)日：2017-01-17
申请号：US14870433
申请日：2015-09-30
Applicant: ADVANCED LIQUID LOGIC, INC.
Inventor： Theodore Winger
CPC classification number: B05B5/087 , B41J2/14 , B41J2/1606 , B41J2002/14322 , B41J2002/14395 , Y10T428/31504 , Y10T428/3154 , Y10T428/31855
Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.
Abstract translation: 一种微流体装置，其具有使用在疏水层下面的导电油墨层制成的导电元件的基板。
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公开(公告)号：US09545640B2
公开(公告)日：2017-01-17
申请号：US14580407
申请日：2014-12-23
Applicant: ADVANCED LIQUID LOGIC, INC.
Inventor： Theodore Winger
CPC classification number: B05B5/087 , B41J2/14 , B41J2/1606 , B41J2002/14322 , B41J2002/14395 , Y10T428/31504 , Y10T428/3154 , Y10T428/31855
Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.
Abstract translation: 一种微流体装置，其具有使用在疏水层下面的导电油墨层制成的导电元件的基板。
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公开(公告)号：US20160085240A1
公开(公告)日：2016-03-24
申请号：US14958514
申请日：2015-12-03
Applicant: Advanced Liquid Logic, Inc.
Inventor： Theodore Winger
CPC classification number: G05D7/0629 , B01L3/0268 , B01L3/502707 , B01L3/502784 , B01L7/52 , B01L2200/0668 , B01L2300/0681 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2300/161 , B01L2300/165 , B01L2400/0427 , B01L2400/043 , Y10T137/0318 , Y10T137/206
Abstract: Droplet actuators that include molecular barrier coatings are provided. The molecular barrier coating may be provided atop the conductive layer of the top substrate, atop the droplet operations electrodes of the bottom substrate, or both. Where the conductive layer of the top substrate and/or the droplet operations electrodes of the bottom substrate are formed of an electrically conductive organic polymer, such as poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS), the molecular barrier coating helps to immobilize the contents of the PEDOT:PSS layer. Further, the molecular barrier coating reduces, preferably entirely eliminates, moisture from seeping into the electrically conducting organic polymer. Methods of conducting droplet operations using the disclosed droplet actuators are also provided.
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Patent Agency Ranking
公开(公告)号：US09707579B2
公开(公告)日：2017-07-18
申请号：US15099175
申请日：2016-04-14
Applicant: Advanced Liquid Logic, Inc.
Inventor： Theodore Winger
CPC classification number: B05B5/087 , B41J2/14 , B41J2/1606 , B41J2002/14322 , B41J2002/14395 , Y10T428/31504 , Y10T428/3154 , Y10T428/31855
Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.
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公开(公告)号：US20160228893A1
公开(公告)日：2016-08-11
申请号：US15099175
申请日：2016-04-14
Applicant: ADVANCED LIQUID LOGIC, INC.
Inventor： Theodore Winger
IPC: B05B5/08
CPC classification number: B05B5/087 , B41J2/14 , B41J2/1606 , B41J2002/14322 , B41J2002/14395 , Y10T428/31504 , Y10T428/3154 , Y10T428/31855
Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.
Abstract translation: 一种微流体装置，其具有使用在疏水层下面的导电油墨层制成的导电元件的基板。
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公开(公告)号：US20130333762A1
公开(公告)日：2013-12-19
申请号：US13915842
申请日：2013-06-12
Applicant: Advanced Liquid Logic Inc.
Inventor： Theodore Winger
IPC: G05D7/06
CPC classification number: G05D7/0629 , B01L3/0268 , B01L3/502707 , B01L3/502784 , B01L7/52 , B01L2200/0668 , B01L2300/0681 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2300/161 , B01L2300/165 , B01L2400/0427 , B01L2400/043 , Y10T137/0318 , Y10T137/206
Abstract: Droplet actuators that include molecular barrier coatings are provided. The molecular barrier coating may be provided atop the conductive layer of the top substrate, atop the droplet operations electrodes of the bottom substrate, or both. Where the conductive layer of the top substrate and/or the droplet operations electrodes of the bottom substrate are formed of an electrically conductive organic polymer, such as poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS), the molecular barrier coating helps to immobilize the contents of the PEDOT:PSS layer. Further, the molecular barrier coating reduces, preferably entirely eliminates, moisture from seeping into the electrically conducting organic polymer. Methods of conducting droplet operations using the disclosed droplet actuators are also provided.
Abstract translation: 提供了包括分子阻隔涂层的液滴致动器。 分子屏障涂层可以设置在顶部基底的导电层顶部，位于底部基底的液滴操作电极顶部，或两者之上。 在顶部基板的导电层和/或底部基板的液滴操作电极由诸如聚（3,4-亚乙基二氧噻吩）聚（苯乙烯磺酸盐）（PEDOT：PSS）的导电有机聚合物形成的情况下，分子 阻隔涂层有助于固定PEDOT：PSS层的内容物。 此外，分子阻隔涂层减少，优选完全消除水分渗透到导电有机聚合物中。 还提供了使用所公开的液滴致动器进行液滴操作的方法。
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公开(公告)号：US20170159105A1
公开(公告)日：2017-06-08
申请号：US15436975
申请日：2017-02-20
Applicant: Advanced Liquid Logic, Inc.
Inventor： Allen E. Eckhardt , Carrie Graham , Ramakrishna Sista , Vamsee K. Pamula , Theodore Winger , Tong Wang , Yalin Xiong , Ning Wu , Sanjay Saha , Gajendrasinh Raolji , Raveendra Dayam
CPC classification number: C12Q1/40 , B01L3/502784 , B01L2300/0654 , B01L2300/0816 , B01L2300/18 , B01L2400/0427 , B01L2400/043 , C07D311/16 , C07D311/18 , C07D311/20 , C07D405/12 , C07D413/12 , C07H15/203 , C07H17/075 , C12Q1/25 , C12Q1/34 , C12Q1/44 , C12Q1/54 , C12Y302/01023 , G01N21/6452 , G01N33/5438 , G01N2333/916 , G01N2333/926 , G01N2333/938 , G01N2800/04
Abstract: The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.
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公开(公告)号：US20160016403A1
公开(公告)日：2016-01-21
申请号：US14870433
申请日：2015-09-30
Applicant: ADVANCED LIQUID LOGIC, INC.
Inventor： Theodore Winger
CPC classification number: B05B5/087 , B41J2/14 , B41J2/1606 , B41J2002/14322 , B41J2002/14395 , Y10T428/31504 , Y10T428/3154 , Y10T428/31855
Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.
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