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    Nitrogen bridgehead compounds having anti-allergic effect
    3.
    发明授权
    Nitrogen bridgehead compounds having anti-allergic effect 失效
    具有抗过敏作用的氮桥头头合成物

    公开(公告)号：US4461769A

    公开(公告)日：1984-07-24

    申请号：US76811

    申请日：1979-09-19

    申请人： Istvan Hermecz ,  Zoltan Meszaros ,  Tibor Breining ,  Sandor Virag ,  Lelle Vasvari nee Debreczy ,  Agnes Horvath ,  Gabor Nagy ,  Attila Mandi ,  Tamas Szucs ,  Istvan Bitter ,  Gyula Sebestyen

    发明人： Istvan Hermecz ,  Zoltan Meszaros ,  Tibor Breining ,  Sandor Virag ,  Lelle Vasvari nee Debreczy ,  Agnes Horvath ,  Gabor Nagy ,  Attila Mandi ,  Tamas Szucs ,  Istvan Bitter ,  Gyula Sebestyen

    IPC分类号： A61K31/505 ,  A61K31/519 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P25/00 ,  A61P25/04 ,  A61P25/20 ,  A61P29/00 ,  A61P31/04 ,  A61P37/08 ,  A61P43/00 ,  C07D471/04

    CPC分类号： C07D471/04 ,  Y10S514/826

    摘要： Compounds of the formula I ##STR1## or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosedwhereinR is hydrogen or lower alkylR.sup.1 is hydrogen, lower alkyl, styryl, or a carboxylic acid; orR and R.sup.1 together form a group of the formula --(CH.dbd.CH).sub.2 -- and in this case the broken line represents a further C--C bond, while in all other cases there is a single bond between positions 6 and 7;R.sup.2 is hydrogen, lower alkyl or hydroxy;R.sup.3 is hydrogen, lower alkyl, aryl, lower alkanoyl, carboxyl or a carboxyl acid derivative or a group of the formula --(CH.sub.2)m--COOH or a derivative thereof formed in the carboxylic group;n=1-3;R.sup.4 is hydrogen, lower alkyl which can be substituted by hydroxy or carboxy; trifluoromethyl, substituted or unsubstituted aryl, phenyl-lower alkyl or substituted or an unsubstituted heterocyclic group;R.sup.5 is hydrogen, lower alkanoyl, substituted or unsubstituted benzoyl or heteroaryl; orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a piperidino, pyrrolidino or morpholino ring; orR.sup.4 and R.sup.5 together with the adjacent nitrogen atom form a group of the formula ##STR2## wherein R.sup.6 is hydrogen and R.sup.7 is substituted or unsubstituted phenyl; andZ is oxygen. The new compounds are useful for treating asthma.

    摘要翻译： 公开了式I的化合物或其药学上可接受的盐，水合物，立体异构体，光学活性异构体，几何异构体或互变异构体，其中R是氢或低级烷基R 1是氢，低级烷基，苯乙烯基或羧酸; 或R和R 1一起形成式 - （CH = CH）2 - 的基团，在这种情况下，虚线代表另外的C-C键，而在所有其它情况下，位置6和7之间存在单键; R2是氢，低级烷基或羟基; R3是在羧基中形成的氢，低级烷基，芳基，低级烷酰基，羧基或羧基酸衍生物或式 - （CH2）m-COOH或其衍生物的基团; n = 1-3; R4是氢，可被羟基或羧基取代的低级烷基; 三氟甲基，取代或未取代的芳基，苯基 - 低级烷基或取代或未取代的杂环基; R5是氢，低级烷酰基，取代或未取代的苯甲酰基或杂芳基; 或R4和R5与相邻的氮原子一起形成哌啶子基，吡咯烷子基或吗啉代环; 或R 4和R 5与相邻的氮原子一起形成下式的基团：其中R6是氢，R7是取代或未取代的苯基; Z是氧。 新化合物可用于治疗哮喘。

    SYSTEM OF EVALUATING WORK CHARACTERISTICS AND PROVIDING WORKSPACE DESIGN SUGGESTIONS
    10.
    发明申请
    SYSTEM OF EVALUATING WORK CHARACTERISTICS AND PROVIDING WORKSPACE DESIGN SUGGESTIONS 审中-公开
    评估工作特性和提供工作空间设计建议的制度

    公开(公告)号：US20130339074A1

    公开(公告)日：2013-12-19

    申请号：US14003611

    申请日：2012-03-07

    申请人： Gabor Nagy ,  Jay L. Brand ,  David A. Fik ,  Sally J. Augustin ,  Haijie Ding ,  David S. Meyer ,  Rick A. Perkins

    发明人： Gabor Nagy ,  Jay L. Brand ,  David A. Fik ,  Sally J. Augustin ,  Haijie Ding ,  David S. Meyer ,  Rick A. Perkins

    IPC分类号： G06Q10/06

    CPC分类号： G06Q10/0631 ,  G06Q10/04 ,  G06Q10/06 ,  G06Q30/02

    摘要： A computer-based system and method are provided for assessing extrinsic and intrinsic work characteristics of people, and storing such data for evaluation of user pre-defined groups' Workstyles and using the Workstyles and additional survey data to develop design implications for the workspace in which such groups will work in an office environment. The Workstyles encompass multiple types of Workstyles which describe characteristics of where and how individual employees work, how much control they have over their work, and what kind of work they do. The design implications provide design guidance, which are expressed in relative terms and provide suggested guidance as to the development of the individual workspaces (workstations) for a group but do not dictate the specific design thereof.

    摘要翻译： 提供了一种基于计算机的系统和方法，用于评估人员的外在和内在工作特征，并存储用于评估用户预定义组的工作台的数据，并使用工作台和附加调查数据来开发工作区的设计意义，其中 这些团体将在办公环境中工作。 Workstyles包含多种类型的Workstyles，它们描述了员工的工作方式，员工工作方式，员工工作状况以及工作方式等方面的特点。 设计意义提供了设计指导，相关术语表达，并为组的个别工作空间（工作站）的开发提供了建议指导，但没有规定其具体设计。