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    System and method for coating a medical device
    3.
    发明授权
    System and method for coating a medical device 失效
    用于涂覆医疗装置的系统和方法

    公开(公告)号：US08043651B2

    公开(公告)日：2011-10-25

    申请号：US11876377

    申请日：2007-10-22

    申请人： Tim O'Connor ,  LiJuan He ,  Aiden Flanagan ,  Anthony Malone ,  Barry Heaney ,  Dave McMorrow

    发明人： Tim O'Connor ,  LiJuan He ,  Aiden Flanagan ,  Anthony Malone ,  Barry Heaney ,  Dave McMorrow

    IPC分类号： A61L33/00

    CPC分类号： B05D1/28 ,  B05D1/002 ,  B05D1/32 ,  Y10T29/49927

    摘要： A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.

    摘要翻译： 一种用于涂覆诸如支架的医疗装置的方法和装置，包括将支架滚压到浸渍有涂层材料的带或凹版辊上。 带和凹版辊可以包括与支架的支柱图案相匹配的凹陷图案。 支架也可以滚动抵靠板或圆柱体，同时通过与支架的支柱图案匹配的板或圆筒中的孔或开口的图案将涂层材料压在支架上。

    SYSTEM AND METHOD FOR COATING A MEDICAL DEVICE
    5.
    发明申请
    SYSTEM AND METHOD FOR COATING A MEDICAL DEVICE 失效
    用于涂敷医疗装置的系统和方法

    公开(公告)号：US20080107794A1

    公开(公告)日：2008-05-08

    申请号：US11876377

    申请日：2007-10-22

    申请人： Tim O'Connor ,  LiJuan He ,  Aiden Flanagan ,  Anthony Malone ,  Barry Heaney ,  Dave McMorrow

    发明人： Tim O'Connor ,  LiJuan He ,  Aiden Flanagan ,  Anthony Malone ,  Barry Heaney ,  Dave McMorrow

    IPC分类号： B05D1/00

    CPC分类号： B05D1/28 ,  B05D1/002 ,  B05D1/32 ,  Y10T29/49927

    摘要： A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.

    摘要翻译： 一种用于涂覆诸如支架的医疗装置的方法和装置，包括将支架滚压到浸渍有涂层材料的带或凹版辊上。 带和凹版辊可以包括与支架的支柱图案相匹配的凹陷图案。 支架也可以滚动抵靠板或圆柱体，同时通过与支架的支柱图案匹配的板或圆筒中的孔或开口的图案将涂层材料压在支架上。

    REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES
    7.
    发明申请
    REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES 审中-公开
    从治疗医疗器械减少爆发

    公开(公告)号：US20080097569A1

    公开(公告)日：2008-04-24

    申请号：US11857849

    申请日：2007-09-19

    申请人： Tim O'Connor ,  Aiden Flanagan ,  Dave McMorrow ,  Anthony Malone

    发明人： Tim O'Connor ,  Aiden Flanagan ,  Dave McMorrow ,  Anthony Malone

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61F2250/0067 ,  A61L31/08 ,  A61L2300/602

    摘要： The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.

    摘要翻译： 本发明一般涉及诸如支架之类的涂覆的医疗装置的调理。 更具体地，本发明涉及用于将洗涤介质中的医疗装置定位在预定时间段内以消除从涂层中爆发释放的方法。 在本发明的方法和方法下，可以鉴定医疗器械靶表面并用治疗剂涂覆。 然后可以将医疗装置的涂覆表面定位在洗脱介质中预定的时间段以释放预定量的涂层。

    STENTS WITH DRUG ELUTING COATINGS
    8.
    发明申请
    STENTS WITH DRUG ELUTING COATINGS 审中-公开
    带药液涂层的手套

    公开(公告)号：US20080281409A1

    公开(公告)日：2008-11-13

    申请号：US11933517

    申请日：2007-11-01

    申请人： Anthony Malone ,  Tim O'Connor ,  Dave McMorrow ,  Aiden Flanagan

    发明人： Anthony Malone ,  Tim O'Connor ,  Dave McMorrow ,  Aiden Flanagan

    IPC分类号： A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622

    摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.

    摘要翻译： 提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。 具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。 医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治​​疗区域。 医疗装置适于插入或植入受试者，优选人。 还提供了制备和使用涂覆的医疗装置的方法。

    INJECTION OF THERAPEUTIC INTO POROUS REGIONS OF A MEDICAL DEVICE
    10.
    发明申请
    INJECTION OF THERAPEUTIC INTO POROUS REGIONS OF A MEDICAL DEVICE 审中-公开
    将治疗注射到医疗器械的多孔区域

    公开(公告)号：US20080077218A1

    公开(公告)日：2008-03-27

    申请号：US11856994

    申请日：2007-09-18

    申请人： Dave McMorrow ,  Tim O'Connor ,  Aiden Flanagan ,  Anthony Malone

    发明人： Dave McMorrow ,  Tim O'Connor ,  Aiden Flanagan ,  Anthony Malone

    IPC分类号： A61N1/00 ,  A61F2/06

    CPC分类号： A61L31/146 ,  A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    摘要： The present invention is directed to methods, processes, and systems for selectively driving therapeutic into at least a portion of a porous matrix of a medical implant. Under methods and processes of the invention, a medical implant may be provided having at least a portion thereof comprising a porous matrix. An injector in fluid communication with a fluid source deliver therapeutic within the porous matrix. The porous matrix may be configured to control the elution rate.

    摘要翻译： 本发明涉及用于选择性地将治疗剂驱动到医用植入物的多孔基质的至少一部分中的方法，方法和系统。 在本发明的方法和方法下，可以提供医疗植入物，其至少一部分包括多孔基质。 与流体源流体连通的注射器在多孔基质内递送治疗剂。 多孔基质可以被配置为控制洗脱速率。