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    Method for quantification of peptide and protein
    1.
    发明授权
    Method for quantification of peptide and protein 有权
    肽和蛋白质定量方法

    公开(公告)号：US08221967B2

    公开(公告)日：2012-07-17

    申请号：US12521632

    申请日：2007-12-27

    申请人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    发明人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2030/8831

    摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

    摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。

    METHOD FOR QUANTIFICATION OF PEPTIDE AND PROTEIN
    2.
    发明申请
    METHOD FOR QUANTIFICATION OF PEPTIDE AND PROTEIN 有权
    肽和蛋白质的定量方法

    公开(公告)号：US20110039287A1

    公开(公告)日：2011-02-17

    申请号：US12521632

    申请日：2007-12-27

    申请人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    发明人： Yoshikazu Morita ,  Aiko Ono ,  Atsushi Serizawa ,  Hiroshi Kawakami

    IPC分类号： C12Q1/44 ,  C12Q1/28 ,  B01D59/44

    CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N2030/8831

    摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

    摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。

    RANKL PRODUCTION INHIBITOR
    3.
    发明申请
    RANKL PRODUCTION INHIBITOR 审中-公开
    RANKL生产抑制剂

    公开(公告)号：US20100099848A1

    公开(公告)日：2010-04-22

    申请号：US12529660

    申请日：2008-02-29

    申请人： Aiko Ono ,  Atsushi Serizawa ,  Yoshikazu Morita ,  Hiroshi Kawakami

    发明人： Aiko Ono ,  Atsushi Serizawa ,  Yoshikazu Morita ,  Hiroshi Kawakami

    IPC分类号： C07K14/00

    CPC分类号： A61K38/018 ,  A23K20/147 ,  A23L33/19 ,  A23V2002/00 ,  A23V2200/306 ,  A23V2200/324 ,  A23V2250/5424

    摘要： The production of RANKL may be inhibited by orally ingesting a milk-derived basic protein. Thus, a RANKL production inhibitor containing a milk-derived basic protein fraction as an active ingredient; a therapeutic agent for a metabolic bone disease and a therapeutic agent for an immune disease each containing the RANKL production inhibitor; and a food/beverage and a feed each containing a specified amount of the RANKL production inhibitor and being characterized by inhibiting the production of RANKL have a remarkable effect of inhibiting the production of RANKL, can be ingested on a daily basis, and exhibit high safety even when being ingested over a long period.

    摘要翻译： 通过口服摄取乳源性碱性蛋白质可以抑制RANKL的产生。 因此，含有乳衍生的碱性蛋白质级分作为活性成分的RANKL产生抑制剂; 每种含有RANKL产生抑制剂的代谢骨疾病治疗剂和免疫疾病治疗剂; 并且每种含有特定量的RANKL产生抑制剂的食品/饮料和饲料，其特征在于抑制RANKL的产生具有显着的抑制RANKL产生的作用，可以每天摄取并显示高安全性 即使长时间摄入也是如此。

    GROWTH HORMONE SECRETION STIMULATOR
    10.
    发明申请
    GROWTH HORMONE SECRETION STIMULATOR 审中-公开
    生长激素分泌刺激物

    公开(公告)号：US20100087372A1

    公开(公告)日：2010-04-08

    申请号：US12531227

    申请日：2008-03-11

    申请人： Aiko Ono ,  Hiroaki Matsuyama ,  Yoshikazu Morita ,  Atsushi Serizawa ,  Satoshi Higurashi

    发明人： Aiko Ono ,  Hiroaki Matsuyama ,  Yoshikazu Morita ,  Atsushi Serizawa ,  Satoshi Higurashi

    IPC分类号： A61K38/17 ,  C07K14/46 ,  A61P5/00

    CPC分类号： A61K38/018 ,  A23L2/52 ,  A23L2/66 ,  A23L33/19

    摘要： Provided are: an agent for promoting growth hormone-secretion, containing a milk-derived basic protein fraction as an active ingredient, with the promotion of growth hormone-secretion being mediated by the promotion of secretion of ghrelin having an effect for promoting growth hormone-secretion; and a method of promoting the secretion of ghrelin by using a milk-derived basic protein fraction. The agent for promoting growth hormone-secretion may be ingested on a daily basis and is highly safe even with its ingestion for a long period.

    摘要翻译： 提供：促进生长激素分泌的药剂，其含有来自乳的碱性蛋白质级分作为活性成分，促进生长激素分泌是通过促进生长激素分泌促进生长激素释放的生长素释放肽介导的， 分泌; 以及通过使用乳源性碱性蛋白质级分促进生长素释放肽的分泌的方法。 促进生长激素分泌的药物可以每天摄入，即使长时间摄取，也是高度安全的。