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公开(公告)号：US20240298669A1
公开(公告)日：2024-09-12
申请号：US18269225
申请日：2021-12-23
申请人： CORNELL UNIVERSITY
发明人： Syed S.H. RIZVI , Bindvi ARORA
摘要： Disclosed are orally dissolving protein extrudates, methods of making the orally dissolving protein extrudates, and edible foods containing the orally dissolving protein extrudates. The orally dissolving protein extrudates can contain milk protein concentrate and be made using supercritical fluid extrusion. The supercritical fluid extrusion can be with a dispersing agent that is a calcium chelating agent such as sodium hexametaphosphate.
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公开(公告)号：US11992024B2
公开(公告)日：2024-05-28
申请号：US17846600
申请日：2022-06-22
CPC分类号： A23C9/1512 , A23C9/1422 , A23C9/16 , A23J1/20
摘要： A method of producing a low-lactose milk protein concentrate comprising the steps of providing a starting liquid milk protein concentrate, pre-treating the milk protein concentration by ultra-sonication, and treating the pre-treated milk protein concentration by diafiltration to provide a calcium depleted low-lactose milk protein concentrate. The process of the invention provides a milk protein concentrate with high levels of protein, less than 1% lactose, and a calcium level that is depleted by at least 20% compared with an untreated milk protein concentrate.
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3.发明授权公开(公告)号：US09661868B2
公开(公告)日：2017-05-30
申请号：US13942909
申请日：2013-07-16
CPC分类号： A23J1/20 , A23J1/202 , A23J1/205 , C07K14/47 , C07K14/79 , C12N9/0065 , C12Y111/01007
摘要： The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a milk source to the matrix, and eluting the lactoferrin from the matrix with an elution buffer comprising about 0.3 to about 2.0 M sodium chloride.
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4.发明申请METHOD OF PRODUCING A COMPOSITION CONTAINING CASEINO-MACROPEPTIDE 审中-公开生产含有CASEINO-MACROPEPTIDE的组合物的方法公开(公告)号：US20140141136A1
公开(公告)日：2014-05-22
申请号：US14081046
申请日：2013-11-15
申请人： Arla Foods Amba
IPC分类号： A23J3/10
CPC分类号： A23C9/1425 , A23C21/00 , A23C2210/206 , A23J1/20 , A23J1/205 , A23J3/10 , A23L33/19 , A23V2002/00 , A23V2250/54246 , A23V2250/55 , A23V2300/30 , A23V2300/34
摘要： The present invention pertains to a method of producing caseinomacropeptide (CMP)-containing compositions in high yield and having a very low content of phenylalanine (Phe). More specifically, the method involves subjecting a whey derived feed to a combination of ultrafiltration and subsequent cation exchange.
摘要翻译： 本发明涉及以高产率制备含酪蛋白多肽（CMP）的组合物并具有非常低含量的苯丙氨酸（Phe）的方法。 更具体地说，该方法包括使乳清衍生的饲料经过超滤和随后的阳离子交换的组合。
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5.发明申请METHOD FOR ISOLATING OSTEOPONTIN USING FEEDS CONTAINING CMP OR CASEIN SPECIES 有权使用含有CMP或CASEIN物种的饲料分离卵磷脂的方法公开(公告)号：US20140051831A1
公开(公告)日：2014-02-20
申请号：US14002578
申请日：2012-03-05
IPC分类号： C07K14/52
摘要： The present invention pertains to a method for isolating osteopontin from a milk-derived feed containing caseino macropeptide and/or free beta casein, such as e.g. a feed based on milk serum or sweet whey. Particularly, the present method involves the use of a narrow window of pH and specific conductance of the milk-derived feed, which surprisingly has proven to provide a very efficient isolation of osteopontin from chemically complex feeds.
摘要翻译： 本发明涉及从含有酪蛋白大肽和/或游离β酪蛋白的乳衍生饲料中分离骨桥蛋白的方法， 基于乳清或甜乳清的饲料。 特别地，本方法涉及使用乳源衍生饲料的pH和比电导的窄窗口，其令人惊奇地证明能够从化学复合饲料提供非常有效的骨桥蛋白的分离。
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公开(公告)号：US08580740B2
公开(公告)日：2013-11-12
申请号：US12740711
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
CPC分类号： A23K50/40 , A21D2/263 , A23C19/082 , A23J1/20 , A23J3/343 , A23K20/147 , A23L2/395 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , C07K14/4703 , A23V2250/5424 , A23V2200/306
摘要： A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.
摘要翻译： 具有以下特性（1）〜（4）的乳蛋白质级分骨吸收抑制效果优异，可用于预防或治疗骨病：（1）乳蛋白质分数来自牛奶; （2）乳蛋白质级分是含有分子量为12,000至16,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为18〜20重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.7〜0.9; 和（4）乳蛋白质分数具有骨吸收抑制作用。
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7.发明申请PROTOCOLS FOR TREATING AND PREVENTING OBESITY AND COMPLICATIONS ARISING THEREFROM 审中-公开用于治疗和预防由此产生的肥胖和综合症的协议公开(公告)号：US20110165138A1
公开(公告)日：2011-07-07
申请号：US13000104
申请日：2009-06-17
申请人： Antonio Rajic , Dominic J. Autelitano , Ana K. Vrkic , Christopher G. Hosking , Leodevico L. Ilag
发明人： Antonio Rajic , Dominic J. Autelitano , Ana K. Vrkic , Christopher G. Hosking , Leodevico L. Ilag
IPC分类号： A61K38/17 , A61K38/44 , C07K14/47 , A61P3/04 , A61P9/00 , A61P3/10 , A61P3/00 , C12N9/08 , C12Q1/02
CPC分类号： A61K38/1709 , A23J1/20 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K38/018 , A61K38/44 , C12Y111/01007 , A23V2200/332 , A23V2250/54252 , A23V2250/54246
摘要： The present invention relates generally to the field of obesity and complications arising therefrom and in particular to the control of obesity by inhibiting adipogenesis and related processes.
摘要翻译： 本发明一般涉及由此产生的肥胖症和并发症领域，特别涉及通过抑制脂肪形成和相关过程来控制肥胖症。
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公开(公告)号：US07956166B2
公开(公告)日：2011-06-07
申请号：US11943778
申请日：2007-11-21
CPC分类号： B01D15/1807 , A23J1/00 , A23J1/20 , A23J1/205 , A23V2002/00 , B01D15/1871 , B01D15/265 , B01D15/424 , B01J20/28004 , B01J20/28011 , B01J20/28016 , B01J20/28052 , B01J20/286 , B01J20/3268 , B01J20/3293 , A23V2250/54242 , A23V2250/54244 , A23V2250/54248 , A23V2250/5425 , A23V2250/5434 , A23V2300/30
摘要： Thus, a primary aspect of the present invention relates to a method for the fractionation of a protein-containing mixture wherein the protein-containing mixture is selected from the group consisting of milk, milk derived products, milk derived raw materials, vegetable derived products, vegetable derived extracts, fruit derived products, fruit derived extracts, fish derived products, and fish derived extracts, said method comprising the steps of: a) optionally adjusting the pH of the mixture; b) applying said mixture to an adsorption column comprising an adsorbent, said adsorbent comprises a particle with at least one high density non-porous core, surrounded by a porous material, the adsorbent having a particle density of at least 1.5 g/ml and a mean particle size of at most 150 μm; c) optionally washing the column; d) eluting at least one protein from the adsorbent.
摘要翻译： 因此，本发明的主要方面涉及一种含蛋白质混合物的分级方法，其中含蛋白质的混合物选自牛奶，奶衍生产品，乳衍生原料，植物衍生产品， 所述方法包括以下步骤：a）任选地调节所述混合物的pH值; b）将所述混合物施加到包含吸附剂的吸附塔上，所述吸附剂包括具有至少一个高密度无孔芯的颗粒，被多孔材料包围，所述吸附剂具有至少1.5g / ml的颗粒密度和 平均粒径至多150μm; c）任选地洗涤柱; d）从吸附剂中洗脱出至少一种蛋白质。
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公开(公告)号：US20100298228A1
公开(公告)日：2010-11-25
申请号：US12740709
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
CPC分类号： A61K35/20 , A21D2/263 , A23C19/082 , A23C19/0917 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A23V2300/30 , A23V2200/306 , A23V2250/5424
摘要： Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
摘要翻译： 公开了一种骨增强剂，其包含具有以下性质（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为6,000至150,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为12〜14重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.5〜0.7; 和（4）乳蛋白质级分具有促进成骨细胞钙化的活性。
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10.发明申请公开(公告)号：US20100261883A1
公开(公告)日：2010-10-14
申请号：US12740711
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
IPC分类号： C07K14/47
CPC分类号： A23K50/40 , A21D2/263 , A23C19/082 , A23J1/20 , A23J3/343 , A23K20/147 , A23L2/395 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , C07K14/4703 , A23V2250/5424 , A23V2200/306
摘要： A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.
摘要翻译： 具有以下特性（1）〜（4）的乳蛋白质级分骨吸收抑制效果优异，可用于预防或治疗骨病：（1）乳蛋白质分数来自牛奶; （2）乳蛋白质级分是含有分子量为12,000至16,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为18〜20重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.7〜0.9; 和（4）乳蛋白质分数具有骨吸收抑制作用。
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