-
1.发明申请公开(公告)号：US20100047231A1
公开(公告)日：2010-02-25
申请号：US12083217
申请日：2006-10-05
申请人： Aintzane Zabaleta Azpiroz , Francisco Borras Cuesta , Jesus Prieto Valtuena , Pablo Sarobe Ugarriza , Juan Jose Lasarte Sagastibelza
发明人： Aintzane Zabaleta Azpiroz , Francisco Borras Cuesta , Jesus Prieto Valtuena , Pablo Sarobe Ugarriza , Juan Jose Lasarte Sagastibelza
IPC分类号： A61K39/29 , A61K39/395 , A61P31/12 , A61K39/39
CPC分类号： A61K39/29 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K16/2878 , C12N2770/24222 , C12N2770/24234 , A61K2300/00
摘要： The present invention relates to an immuno-stimulant combination for prophylaxis and treatment of hepatitis C, characterised in that it comprises: a TLR3 agonist, a CD40 agonist and the NS3 protein of the hepatitis C virus. Moreover, the invention relates to the pharmaceutical compositions comprising said immuno-stimulant combination, to the use thereof, and to a kit composed of said pharmaceutical compositions. Finally, the present invention relates to a method for producing an immune response to the hepatitis C virus and to a vaccine against said virus.
摘要翻译： 本发明涉及用于预防和治疗丙型肝炎的免疫兴奋剂组合物，其特征在于其包含：TLR3激动剂，CD40激动剂和丙型肝炎病毒的NS3蛋白。 此外，本发明涉及包含所述免疫兴奋剂组合及其用途的药物组合物以及由所述药物组合物组成的试剂盒。 最后，本发明涉及一种用于产生对丙型肝炎病毒的免疫应答的方法和针对所述病毒的疫苗。
-
2.发明申请USE OF TGF-B1 INHIBITOR PEPTIDES IN THE PREPARATION OF AN IMMUNE RESPONSE MODULATING AGENT 审中-公开TGF-B1抑制剂肽在制备免疫应答调节剂中的应用公开(公告)号：US20090263410A1
公开(公告)日：2009-10-22
申请号：US12091281
申请日：2005-10-24
申请人： Francisco Borras Cuesta , Noelia Casares Agar , Javier Dotor De Las Herrerias , Lucia Gil Guerrero , Juan Jose Lasarte Sagastibelza , Pablo Sarobe Ugarriza , Jesus Prieto Valtuena
发明人： Francisco Borras Cuesta , Noelia Casares Agar , Javier Dotor De Las Herrerias , Lucia Gil Guerrero , Juan Jose Lasarte Sagastibelza , Pablo Sarobe Ugarriza , Jesus Prieto Valtuena
CPC分类号： A61K38/10 , Y02A50/41 , Y02A50/414
摘要： The present invention relates to the use of a peptide inhibiting TGF-β1 selected from: peptide p144 whose sequence corresponds to SEQ ID NO: 1, peptide p17 whose sequence corresponds to SEQ ID NO: 2, a peptide which has at least 90% homology therewith, or fragments of the above, in the preparation of an immune response modulating agent.
摘要翻译： 本发明涉及抑制TGF-β1的肽的用途，所述肽选自：肽序列对应于SEQ ID NO：1的肽p144，其序列对应于SEQ ID NO：2的肽p17，具有至少90％同源性的肽 或其片段，在免疫应答调节剂的制备中。
-
公开(公告)号：US20090220533A1
公开(公告)日：2009-09-03
申请号：US12086972
申请日：2006-12-19
申请人： Francisco Borras Cuesta , Juan Jose Lasarte Sagastibelza , Marta Ruiz Egozcue , Pablo Sarobe Ugarriza
发明人： Francisco Borras Cuesta , Juan Jose Lasarte Sagastibelza , Marta Ruiz Egozcue , Pablo Sarobe Ugarriza
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K7/06 , C07K14/70539
摘要： The invention relates to a chimeric peptide, which can bind to at least one allelic form of the HLA-DR molecule. The invention also relates to a pharmaceutical composition containing said peptide, as well as to the different uses of same.
摘要翻译： 本发明涉及可以结合至少一种等位基因形式的HLA-DR分子的嵌合肽。 本发明还涉及含有所述肽的药物组合物以及其不同用途。
-
4.发明授权Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) 失效具有与转化生长因子结合能力的肽1（TGF-β1）公开(公告)号：US07666841B2
公开(公告)日：2010-02-23
申请号：US10569012
申请日：2004-07-05
申请人： Javier Dotor De Las Herrerías , Ana Belen Lopez Vazquez , Juan Jose Lasarte Sagastibelza , Jesus Prieto Valtuena , Francisco Borras Cuesta
发明人： Javier Dotor De Las Herrerías , Ana Belen Lopez Vazquez , Juan Jose Lasarte Sagastibelza , Jesus Prieto Valtuena , Francisco Borras Cuesta
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C12N2770/36111
摘要： The described peptides possess the capacity to bind to Transforming Growth Factor TGF-β1 (TGF-β1), and are potential inhibitors of the biological activity of TGF-β1 through direct binding to this cytokine. These peptides can be used in the treatment of diseases or pathological alterations based on excessive or deregulated TGF-β1 expression.
摘要翻译： 所述的肽具有与转化生长因子TGF-β1（TGF-β1）结合的能力，并且通过直接结合该细胞因子是TGF-β1的生物学活性的潜在抑制剂。 这些肽可用于治疗基于过量或失调的TGF-β1表达的疾病或病理改变。
-
公开(公告)号：US20120237535A1
公开(公告)日：2012-09-20
申请号：US13394610
申请日：2010-09-10
申请人： Pedro Berraondo-Lopez , Juan Jose Lasarte Sagastibelza , Christina Mansilla Puerta , Jesus Maria Prieto Valtuena , Pablo Sarobe Ugarriza
发明人： Pedro Berraondo-Lopez , Juan Jose Lasarte Sagastibelza , Christina Mansilla Puerta , Jesus Maria Prieto Valtuena , Pablo Sarobe Ugarriza
IPC分类号： A61K39/12 , C12N15/62 , A61P31/20 , A61P35/00 , C12N5/0784 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C07K19/00 , A61P37/04
CPC分类号： A61K47/48292 , A61K35/12 , A61K38/00 , A61K39/12 , A61K47/6435 , A61K47/646 , A61K2039/5154 , A61K2039/55561 , A61K2039/585 , A61K2039/6031 , C07K14/005 , C07K14/78 , C07K2319/75 , C12N2710/20022 , C12N2710/20032 , C12N2710/20034
摘要： The invention relates to immunogenic conjugates comprising an immunogenic region of human papilloma virus E7 protein and the fibronectin EDA region, as well to compositions comprising said conjugates and to dendritic cells obtained by stimulation with said conjugates and compositions. Moreover, the invention relates to methods for the treatment of diseases caused by the human papilloma virus (HPV) using said conjugates, compositions and dendritic cells.
摘要翻译： 本发明涉及包含人乳头状瘤病毒E7蛋白和纤连蛋白EDA区域的免疫原性区域的免疫原性缀合物，以及包含所述缀合物的组合物和通过用所述缀合物和组合物刺激获得的树突状细胞。 此外，本发明涉及使用所述缀合物，组合物和树突状细胞治疗由人乳头瘤病毒（HPV）引起的疾病的方法。
-
6.发明授权公开(公告)号：US09155783B2
公开(公告)日：2015-10-13
申请号：US11922148
申请日：2006-06-13
IPC分类号： A61K6/00 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/38 , A61K38/39 , A61K39/00 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/78
CPC分类号： C07K14/78 , A61K38/39 , A61K39/0011 , C07K14/77 , C07K2319/33 , C07K2319/40 , C12N2770/24211 , C12N2770/24234
摘要： This invention relates to the use of a polypeptide in the production of an immunostimulatory agent, said polypeptide comprising a sequence corresponding to the EDA domain of fibronectin, a fragment of the EDA domain which can bind to TLR4 or a variant of said EDA domain or a fragment which can bind to TLR4 and which has a homology of more than 70% with any form or natural fragment of the EDA domain. The invention also relates to the production methods and applications of said agent.
摘要翻译： 本发明涉及多肽在产生免疫刺激剂中的用途，所述多肽包含对应于纤连蛋白的EDA结构域的序列，EDA结构域的片段可结合TLR4或所述EDA结构域的变体或 片段，其可与TLR4结合并且与EDA结构域的任何形式或天然片段具有多于70％的同源性。 本发明还涉及所述试剂的制备方法和应用。
-
7.发明申请公开(公告)号：US20090220532A1
公开(公告)日：2009-09-03
申请号：US11922148
申请日：2006-06-13
CPC分类号： C07K14/78 , A61K38/39 , A61K39/0011 , C07K14/77 , C07K2319/33 , C07K2319/40 , C12N2770/24211 , C12N2770/24234
摘要： This invention relates to the use of a polypeptide in the production of an immunostimulatory agent, said polypeptide comprising a sequence corresponding to the EDA domain of fibronectin, a fragment of the EDA domain which can bind to TLR4 or a variant of said EDA domain or a fragment which can bind to TLR4 and which has a homology of more than 70% with any form or natural fragment of the EDA domain. The invention also relates to the production methods and applications of said agent.
摘要翻译： 本发明涉及多肽在产生免疫刺激剂中的用途，所述多肽包含对应于纤连蛋白的EDA结构域的序列，EDA结构域的片段可结合TLR4或所述EDA结构域的变体或 片段，其可与TLR4结合并且与EDA结构域的任何形式或天然片段具有多于70％的同源性。 本发明还涉及所述试剂的制备方法和应用。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.028 秒)
