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公开(公告)号：US20110076304A1
公开(公告)日：2011-03-31
申请号：US12993803
申请日：2009-05-19
申请人： Alexander Pereboev , George Tsuladze , Igor Bogdashin , Itziar Echeverria Beistegui , Juan José Lasarte Sagastibelza , Jesùs Maria Prieto Valtueña , Pablo Sarobe Ugarriza
发明人： Alexander Pereboev , George Tsuladze , Igor Bogdashin , Itziar Echeverria Beistegui , Juan José Lasarte Sagastibelza , Jesùs Maria Prieto Valtueña , Pablo Sarobe Ugarriza
IPC分类号： A61K39/235 , C12N7/00 , A61P37/04
CPC分类号： C12N15/86 , A61K39/12 , A61K39/29 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/55 , C07K14/005 , C07K14/705 , C07K14/70575 , C07K2319/21 , C07K2319/32 , C07K2319/33 , C07K2319/735 , C07K2319/74 , C12N2710/10343 , C12N2710/10345 , C12N2770/24222 , C12N2770/24234 , C12N2810/855
摘要： The invention relates to an adapter protein comprising a coxackievirus and adenovirus receptor (CAR) region and a human CD40 ligand and to the uses thereof for promoting adenoviral transduction of dendritic cells while at the same time promoting maturation of the DCs. The invention also relates to pharmaceutical compositions comprising said adapter protein and an adenovirus encoding an antigen and the uses thereof in a method for eliciting an immune response against the antigen encoded in said adenovirus as well as to antigen-loaded dendritic cells obtained the adaptor protein and an adenovirus and to the uses thereof in a method of eliciting an immune response against the antigen encoded in the adenovirus.
摘要翻译： 本发明涉及包含柯萨奇病毒和腺病毒受体（CAR）区域和人CD40配体的衔接蛋白，并且涉及其用于促进树突状细胞的腺病毒转导，同时促进DC成熟。 本发明还涉及包含所述衔接蛋白和编码抗原的腺病毒的药物组合物及其在用于引发针对所述腺病毒中编码的抗原的免疫应答的方法中的用途以及获得衔接蛋白的抗原负载的树突状细胞，以及 一种腺病毒及其在引发针对编码在腺病毒中的抗原的免疫应答的方法中的用途。
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公开(公告)号：US20110268757A1
公开(公告)日：2011-11-03
申请号：US13132530
申请日：2009-12-02
申请人： Francisco Borrás Cuesta , Inés Noelia Casares Lagar , María del Carmen Durántez Delgado , Juan José Lasarte Sagastibelza , Claude Leclerc , Jesús María Prieto Valtueña , Pablo Sarobe Ugarriza
发明人： Francisco Borrás Cuesta , Inés Noelia Casares Lagar , María del Carmen Durántez Delgado , Juan José Lasarte Sagastibelza , Claude Leclerc , Jesús María Prieto Valtueña , Pablo Sarobe Ugarriza
CPC分类号： C07K14/31 , A61K39/385 , A61K2039/55561 , A61K2039/6068 , C07K14/47 , C07K2319/00
摘要： The invention relates to methods for increasing immunogenicity of an antigenic peptide by means of its covalent coupling to a modulin derived peptide (PSM, phenol soluble modulin). In particular, the binding of PSMα, PSMγ and PSMδ peptides to an antigen (from a pathogen or a tumor associated protein) increases the capacity of the antigen to activate an immune response in vivo. Thus, the PSMα, PSMγ and PSMδ peptides bound to these antigens may be used in the development of vaccines for preventing or treating infectious diseases or cancer
摘要翻译： 本发明涉及通过其与调节蛋白衍生肽（PSM，苯酚可溶性调节素）的共价偶联增加抗原肽的免疫原性的方法。 特别地，PSMα，PSMγ和PSMδ肽与抗原（来自病原体或肿瘤相关蛋白）的结合增加了抗原在体内激活免疫应答的能力。 因此，与这些抗原结合的PSMα，PSMγ和PSMδ肽可用于开发用于预防或治疗感染性疾病或癌症的疫苗
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公开(公告)号：US20090220533A1
公开(公告)日：2009-09-03
申请号：US12086972
申请日：2006-12-19
申请人： Francisco Borras Cuesta , Juan Jose Lasarte Sagastibelza , Marta Ruiz Egozcue , Pablo Sarobe Ugarriza
发明人： Francisco Borras Cuesta , Juan Jose Lasarte Sagastibelza , Marta Ruiz Egozcue , Pablo Sarobe Ugarriza
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K7/06 , C07K14/70539
摘要： The invention relates to a chimeric peptide, which can bind to at least one allelic form of the HLA-DR molecule. The invention also relates to a pharmaceutical composition containing said peptide, as well as to the different uses of same.
摘要翻译： 本发明涉及可以结合至少一种等位基因形式的HLA-DR分子的嵌合肽。 本发明还涉及含有所述肽的药物组合物以及其不同用途。
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4.发明申请公开(公告)号：US20130064790A1
公开(公告)日：2013-03-14
申请号：US13415151
申请日：2012-03-08
申请人： Lorea MANTEROLA CAREAGA , Inés Noelia CASARES LAGAR , Nancy Díaz-Valdés Farray , Javier DOTOR DE LAS HERRERÍAS , Juan José LASARTE SAGASTIBELZA , Pablo SAROBE UGARRIZA , Jesús PRIETO VALTUEÑA , Francisco BORRÁS CUESTA
发明人： Lorea MANTEROLA CAREAGA , Inés Noelia CASARES LAGAR , Nancy Díaz-Valdés Farray , Javier DOTOR DE LAS HERRERÍAS , Juan José LASARTE SAGASTIBELZA , Pablo SAROBE UGARRIZA , Jesús PRIETO VALTUEÑA , Francisco BORRÁS CUESTA
IPC分类号： A61K38/10 , A61K39/395 , A61K35/74 , C12P21/02 , C12N15/11 , C12N15/70 , A61P31/14 , A61P35/00 , A61K31/7088 , C07K7/08 , A61K38/21 , C12N1/21
CPC分类号： C07K14/5428
摘要： The invention relates to peptides having the capacity to bind to interleukin-10 (IL-10) and their use in the treatment of clinical conditions or pathological disorders associated to IL-10 expression, particularly to a high IL-10 expression, for example, infectious diseases, tumors, cancers and acute damage conditions.
摘要翻译： 本发明涉及具有结合白细胞介素-10（IL-10）的能力的肽及其在治疗与IL-10表达相关的临床病症或病理学障碍，特别是高IL-10表达的用途中的用途， 传染病，肿瘤，癌症和急性损伤病症。
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5.发明申请公开(公告)号：US20100047231A1
公开(公告)日：2010-02-25
申请号：US12083217
申请日：2006-10-05
申请人： Aintzane Zabaleta Azpiroz , Francisco Borras Cuesta , Jesus Prieto Valtuena , Pablo Sarobe Ugarriza , Juan Jose Lasarte Sagastibelza
发明人： Aintzane Zabaleta Azpiroz , Francisco Borras Cuesta , Jesus Prieto Valtuena , Pablo Sarobe Ugarriza , Juan Jose Lasarte Sagastibelza
IPC分类号： A61K39/29 , A61K39/395 , A61P31/12 , A61K39/39
CPC分类号： A61K39/29 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/55516 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K16/2878 , C12N2770/24222 , C12N2770/24234 , A61K2300/00
摘要： The present invention relates to an immuno-stimulant combination for prophylaxis and treatment of hepatitis C, characterised in that it comprises: a TLR3 agonist, a CD40 agonist and the NS3 protein of the hepatitis C virus. Moreover, the invention relates to the pharmaceutical compositions comprising said immuno-stimulant combination, to the use thereof, and to a kit composed of said pharmaceutical compositions. Finally, the present invention relates to a method for producing an immune response to the hepatitis C virus and to a vaccine against said virus.
摘要翻译： 本发明涉及用于预防和治疗丙型肝炎的免疫兴奋剂组合物，其特征在于其包含：TLR3激动剂，CD40激动剂和丙型肝炎病毒的NS3蛋白。 此外，本发明涉及包含所述免疫兴奋剂组合及其用途的药物组合物以及由所述药物组合物组成的试剂盒。 最后，本发明涉及一种用于产生对丙型肝炎病毒的免疫应答的方法和针对所述病毒的疫苗。
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公开(公告)号：US08524860B2
公开(公告)日：2013-09-03
申请号：US12743616
申请日：2008-11-14
申请人： Inés Noelia Casares Lagar , Francisco Borrás Cuesta , Pablo Sarobe Ugarriza , Jesús Maria Prieto Valtueña , Juan José Lasarte Sagastibelza
发明人： Inés Noelia Casares Lagar , Francisco Borrás Cuesta , Pablo Sarobe Ugarriza , Jesús Maria Prieto Valtueña , Juan José Lasarte Sagastibelza
IPC分类号： C07K2/00
CPC分类号： C12N5/0636 , C07K7/08
摘要： The invention relates to peptides of general formula (I), wherein X is absent or X is present and is X14 or X14-X15, wherein X14 and X15, independently from one another, represent an amino acid; their functional variants and fragments, and their pharmaceutically acceptable salts, having the capacity to bind to scurfin and inhibit its biological activity, therefore they regulate or block the activity of regulatory T (Treg) lymphocytes. They are applicable in the treatment of infectious and neoplastic diseases. (I) Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe- Phe-X
摘要翻译： 本发明涉及通式（I）的肽，其中X不存在或X存在且为X 14或X 14 -X 15，其中X 14和X 15彼此独立地表示氨基酸; 它们的功能变体和片段及其药学上可接受的盐，具有与scurfin结合并抑制其生物活性的能力，因此它们调节或阻断调节性T（Treg）淋巴细胞的活性。 它们适用于感染性和肿瘤性疾病的治疗。 （I）Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-X
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公开(公告)号：US08148334B2
公开(公告)日：2012-04-03
申请号：US12593321
申请日：2008-03-27
申请人： Lorea Manterola Careaga , Inés Noelia Casares Lagar , Nancy Díaz-Valdés Farray , Javier Dotor de las Herrerías , Juan José Lasarte Sagastibelza , Pablo Sarobe Ugarriza , Jesús Prieto Valtueñ , Francisco Borrás Cuesta
发明人： Lorea Manterola Careaga , Inés Noelia Casares Lagar , Nancy Díaz-Valdés Farray , Javier Dotor de las Herrerías , Juan José Lasarte Sagastibelza , Pablo Sarobe Ugarriza , Jesús Prieto Valtueñ , Francisco Borrás Cuesta
CPC分类号： C07K14/5428
摘要： The invention relates to peptides having the capacity to bind to interleukin-10 (IL-10) and their use in the treatment of clinical conditions or pathological disorders associated to IL-10 expression, particularly to a high IL-10 expression, for example, infectious diseases, tumors, cancers and acute damage conditions.
摘要翻译： 本发明涉及具有结合白细胞介素-10（IL-10）的能力的肽及其在治疗与IL-10表达相关的临床病症或病理学障碍，特别是高IL-10表达的用途中的用途， 传染病，肿瘤，癌症和急性损伤病症。
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公开(公告)号：US20100267623A1
公开(公告)日：2010-10-21
申请号：US12743616
申请日：2008-11-14
申请人： Inés Noelia Casares Lagar , Francisco Borras Cuesta , Pablo Sarobe Ugarriza , Jesús Prieto Valtueña , Juan José Lasarte Sagastibelza
发明人： Inés Noelia Casares Lagar , Francisco Borras Cuesta , Pablo Sarobe Ugarriza , Jesús Prieto Valtueña , Juan José Lasarte Sagastibelza
IPC分类号： A61K38/10 , C07K7/08 , C07K14/00 , A61P35/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , C07H21/04 , C12N15/63 , C12N1/00 , C12P21/06
CPC分类号： C12N5/0636 , C07K7/08
摘要： The invention relates to peptides of general formula (I), wherein X is absent or X is present and is X14 or X14-X15, wherein X14 and X15, independently from one another, represent an amino acid; their functional variants and fragments, and their pharmaceutically acceptable salts, having the capacity to bind to scurfin and inhibit its biological activity, therefore they regulate or block the activity of regulatory T (Treg) lymphocytes. They are applicable in the treatment of infectious and neoplastic diseases. Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe- Phe-X (I)
摘要翻译： 本发明涉及通式（I）的肽，其中X不存在或X存在且为X 14或X 14 -X 15，其中X 14和X 15彼此独立地表示氨基酸; 它们的功能变体和片段及其药学上可接受的盐，具有与scurfin结合并抑制其生物活性的能力，因此它们调节或阻断调节性T（Treg）淋巴细胞的活性。 它们适用于感染性和肿瘤性疾病的治疗。 Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-X（I）
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公开(公告)号：US20120237535A1
公开(公告)日：2012-09-20
申请号：US13394610
申请日：2010-09-10
申请人： Pedro Berraondo-Lopez , Juan Jose Lasarte Sagastibelza , Christina Mansilla Puerta , Jesus Maria Prieto Valtuena , Pablo Sarobe Ugarriza
发明人： Pedro Berraondo-Lopez , Juan Jose Lasarte Sagastibelza , Christina Mansilla Puerta , Jesus Maria Prieto Valtuena , Pablo Sarobe Ugarriza
IPC分类号： A61K39/12 , C12N15/62 , A61P31/20 , A61P35/00 , C12N5/0784 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C07K19/00 , A61P37/04
CPC分类号： A61K47/48292 , A61K35/12 , A61K38/00 , A61K39/12 , A61K47/6435 , A61K47/646 , A61K2039/5154 , A61K2039/55561 , A61K2039/585 , A61K2039/6031 , C07K14/005 , C07K14/78 , C07K2319/75 , C12N2710/20022 , C12N2710/20032 , C12N2710/20034
摘要： The invention relates to immunogenic conjugates comprising an immunogenic region of human papilloma virus E7 protein and the fibronectin EDA region, as well to compositions comprising said conjugates and to dendritic cells obtained by stimulation with said conjugates and compositions. Moreover, the invention relates to methods for the treatment of diseases caused by the human papilloma virus (HPV) using said conjugates, compositions and dendritic cells.
摘要翻译： 本发明涉及包含人乳头状瘤病毒E7蛋白和纤连蛋白EDA区域的免疫原性区域的免疫原性缀合物，以及包含所述缀合物的组合物和通过用所述缀合物和组合物刺激获得的树突状细胞。 此外，本发明涉及使用所述缀合物，组合物和树突状细胞治疗由人乳头瘤病毒（HPV）引起的疾病的方法。
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10.发明申请ONCOSTATIN M AS PROMOTER OF IMMUNOSTIMULATORY ACTIVITY OF HUMAN EPITHELIAL CELLS 审中-公开ONCOSTATIN M作为人上皮细胞免疫活性的促进剂公开(公告)号：US20110195047A1
公开(公告)日：2011-08-11
申请号：US13123031
申请日：2009-10-06
申请人： Rafael Aldabe Arregui , Iranzu González De La Tajada , Maria Esther Larrea Leoz , Jesús Maria Prieto Valtueña , Pablo Sarobe Ugarriza
发明人： Rafael Aldabe Arregui , Iranzu González De La Tajada , Maria Esther Larrea Leoz , Jesús Maria Prieto Valtueña , Pablo Sarobe Ugarriza
CPC分类号： A61K39/39 , A61K38/204 , A61K38/21 , A61K2039/5158 , A61K2039/55522 , A61K2039/57 , A61K2300/00
摘要： The invention relates to the use of oncostatin M (OSM), an OSM receptor (OSMR) agonist, or a combination of OSM or a OSMR agonist with an interferon type I; in the manufacture of a medicament for enhancing the immunostimulatory activity of epithelial cells in a human.
摘要翻译： 本发明涉及制瘤素M（OSM），OSM受体（OSMR）激动剂或OSM或OSMR激动剂与I型干扰素的组合的用途; 在制备用于增强人中上皮细胞的免疫刺激活性的药物中。
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