-
1.发明授权Compositions, methods, and systems for the synthesis and use of imaging agents 有权用于合成和使用成像剂的组合物，方法和系统公开(公告)号：US09388125B2
公开(公告)日：2016-07-12
申请号：US13697287
申请日：2011-05-11
申请人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
发明人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
IPC分类号： A61K51/00 , A61M36/14 , C07C277/08 , A61K51/04 , C07B59/00 , C07C53/06 , C07C217/58 , C07C255/54 , C07C279/10 , C07C279/24 , C07C309/65 , C07C309/66 , C07C309/73 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C303/28 , C07C303/30 , C07C309/04 , C07C309/30 , C07C277/00
CPC分类号： C07C303/30 , A61K51/00 , A61K51/04 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C53/06 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C217/58 , C07C255/54 , C07C277/00 , C07C277/08 , C07C279/10 , C07C279/24 , C07C303/28 , C07C309/04 , C07C309/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07C279/08
摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
摘要翻译： 本发明一般涉及可用于医学成像的新型合成方法，系统，试剂盒，盐和前体。 在一些实施方案中，本发明提供了包含可以使用本文所述的合成方法形成的成像剂前体的组合物。 可以使用本文所述的方法将成像剂转化成成像剂。 在某些情况下，成像剂富集于18F。 在一些情况下，包括盐形式的成像剂（例如抗坏血酸盐）可用于对受试者感兴趣的区域进行成像，包括但不限于心脏，心血管系统，心脏血管，脑和其他器官 。
-
2.发明申请COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS 有权用于合成和成像剂使用的组合物，方法和系统公开(公告)号：US20130149244A1
公开(公告)日：2013-06-13
申请号：US13697287
申请日：2011-05-11
申请人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
发明人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
IPC分类号： C07C277/08 , C07C213/02 , C07C309/73 , C07C309/66 , C07C53/18 , C07B59/00 , C07C53/10 , C07C63/08 , C07C309/04 , C07C303/30 , C07C303/28 , A61K51/04 , C07C309/30
CPC分类号： C07C303/30 , A61K51/00 , A61K51/04 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C53/06 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C217/58 , C07C255/54 , C07C277/00 , C07C277/08 , C07C279/10 , C07C279/24 , C07C303/28 , C07C309/04 , C07C309/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07C279/08
摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
摘要翻译： 本发明一般涉及可用于医学成像的新型合成方法，系统，试剂盒，盐和前体。 在一些实施方案中，本发明提供了包含可以使用本文所述的合成方法形成的成像剂前体的组合物。 可以使用本文所述的方法将成像剂转化成成像剂。 在某些情况下，成像剂富集于18F。 在一些情况下，包括盐形式的成像剂（例如抗坏血酸盐）可用于对受试者感兴趣的区域进行成像，包括但不限于心脏，心血管系统，心脏血管，脑和其他器官 。
-
公开(公告)号：US20130064769A1
公开(公告)日：2013-03-14
申请号：US13577674
申请日：2011-02-08
申请人： Richard R. Cesati , Edward H. Cheesman , Joel Lazewatsky , Heike S. Radeke , James F. Castner , Enrico Mongeau , Dianne D. Zdankiewicz , Robert Wilburn Siegler , Marybeth Devine
发明人： Richard R. Cesati , Edward H. Cheesman , Joel Lazewatsky , Heike S. Radeke , James F. Castner , Enrico Mongeau , Dianne D. Zdankiewicz , Robert Wilburn Siegler , Marybeth Devine
IPC分类号： A61K51/04 , B01J19/00 , C07D237/16
CPC分类号： A61K51/0459 , C07D237/16 , C07D407/12
摘要： The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.
-
4.发明授权Methods and apparatus for synthesizing imaging agents, and intermediates thereof 有权用于合成成像剂的方法和装置及其中间体公开(公告)号：US08936777B2
公开(公告)日：2015-01-20
申请号：US13577674
申请日：2011-02-08
申请人： Richard R. Cesati , Edward H. Cheesman , Joel Lazewatsky , Heike S. Radeke , Enrico Mongeau , Dianne D. Zdankiewicz , Marybeth Devine
发明人： Richard R. Cesati , Edward H. Cheesman , Joel Lazewatsky , Heike S. Radeke , Enrico Mongeau , Dianne D. Zdankiewicz , Marybeth Devine
IPC分类号： A61K51/04 , C07D237/16 , C07D407/12
CPC分类号： A61K51/0459 , C07D237/16 , C07D407/12
摘要： The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.
摘要翻译： 本发明一般涉及用于合成显像剂及其前体的方法和系统。 所述方法可以显示出提高的产量，并且可以允许大规模合成显像剂，包括包含放射性同位素（例如18F）的成像剂。 本发明的各种实施例可以用作传感器，诊断工具等。 在某些情况下，提供了评估灌注的方法，包括心肌灌注。 本发明的合成方法也已经并入自动合成单元中以制备和纯化包含放射性同位素的成像剂。 在一些实施方案中，本发明提供了包含成像剂1的新型方法和系统，包括在受试者中成像的方法，包括通过注射，输注或任何其它已知方法向受试者施用包含成像剂1的组合物， 感兴趣的事件所在的对象的区域。
-
公开(公告)号：US20110091374A1
公开(公告)日：2011-04-21
申请号：US12919600
申请日：2009-02-27
CPC分类号： A61K51/0459
摘要： The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a contrast agent which comprises a compound that binds MC-I, and an imaging moiety, and scanning the subject using diagnostic imaging.
摘要翻译： 本发明部分地涉及用于对中枢神经系统或癌症进行成像的化合物和方法，包括向受试者施用包含结合MC-1的化合物和成像部分的造影剂，并使用 诊断成像。
-
公开(公告)号：US09408927B2
公开(公告)日：2016-08-09
申请号：US12919600
申请日：2009-02-27
CPC分类号： A61K51/0459
摘要： The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a contrast agent which comprises a compound that binds MC-I, and an imaging moiety, and scanning the subject using diagnostic imaging.
摘要翻译： 本发明部分地涉及用于对中枢神经系统或癌症进行成像的化合物和方法，包括向受试者施用包含结合MC-1的化合物和成像部分的造影剂，并使用 诊断成像。
-
公开(公告)号：US06808698B1
公开(公告)日：2004-10-26
申请号：US09534893
申请日：2000-03-24
申请人： Joel Lazewatsky
发明人： Joel Lazewatsky
IPC分类号： A61K4900
CPC分类号： A61K51/088
摘要： A method wherein a radiolabelled compound is localized at a thrombus. Two-dimensional images, representing a physical property associated with the radiolabelled thrombus, are acquired and assembled into a three-dimensional matrix of data. The three-dimensional matrix of data is then scanned along an array of parallel lines to determine a maximum value along each line. The maximum value along each line is then assigned to a pixel in a two-dimensional array, where the relative position of the pixel in the two-dimensional array corresponds to the relative position of the line in the array of parallel lines.
摘要翻译： 放射性标记化合物定位于血栓的方法。 代表与放射性标记血栓相关的物理性质的二维图像被采集并组装成三维数据矩阵。 然后沿着平行线阵列扫描数据的三维矩阵，以确定沿着每条线的最大值。 然后，沿着每条线的最大值被分配给二维阵列中的像素，其中二维阵列中的像素的相对位置对应于线在平行线阵列中的相对位置。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.038 秒)
