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22 条记录 (耗时 0.032 秒)

    Methods and apparatus for synthesizing imaging agents, and intermediates thereof
    2.
    发明授权
    Methods and apparatus for synthesizing imaging agents, and intermediates thereof 有权
    用于合成成像剂的方法和装置及其中间体

    公开(公告)号：US08936777B2

    公开(公告)日：2015-01-20

    申请号：US13577674

    申请日：2011-02-08

    申请人： Richard R. Cesati ,  Edward H. Cheesman ,  Joel Lazewatsky ,  Heike S. Radeke ,  Enrico Mongeau ,  Dianne D. Zdankiewicz ,  Marybeth Devine

    发明人： Richard R. Cesati ,  Edward H. Cheesman ,  Joel Lazewatsky ,  Heike S. Radeke ,  Enrico Mongeau ,  Dianne D. Zdankiewicz ,  Marybeth Devine

    IPC分类号： A61K51/04 ,  C07D237/16 ,  C07D407/12

    CPC分类号： A61K51/0459 ,  C07D237/16 ,  C07D407/12

    摘要： The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

    摘要翻译： 本发明一般涉及用于合成显像剂及其前体的方法和系统。 所述方法可以显示出提高的产量，并且可以允许大规模合成显像剂，包括包含放射性同位素（例如18F）的成像剂。 本发明的各种实施例可以用作传感器，诊断工具等。 在某些情况下，提供了评估灌注的方法，包括心肌灌注。 本发明的合成方法也已经并入自动合成单元中以制备和纯化包含放射性同位素的成像剂。 在一些实施方案中，本发明提供了包含成像剂1的新型方法和系统，包括在受试者中成像的方法，包括通过注射，输注或任何其它已知方法向受试者施用包含成像剂1的组合物， 感兴趣的事件所在的对象的区域。

    Methods for preparing 2-alkynyladenosine deriviatives
    10.
    发明申请
    Methods for preparing 2-alkynyladenosine deriviatives 失效
    2-炔基腺苷衍生物的制备方法

    公开(公告)号：US20080177055A1

    公开(公告)日：2008-07-24

    申请号：US11975080

    申请日：2007-10-17

    申请人： Iain F. Pickersgill ,  Edward H. Cheesman

    发明人： Iain F. Pickersgill ,  Edward H. Cheesman

    IPC分类号： C07H19/16

    CPC分类号： C07H19/16

    摘要： Disclosed are methods for preparing 2-alkynyladenosine derivatives of formula A: or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step of: contacting 2-iodoadenosine-5′-N-ethyluronamide with a compound of formula B: wherein Z is —C(═O)OR or —CH2C(═O)R, where R is a C1 to C5 alkyl, preferably The methods are useful for preparing 2-alkynyladenosine derivatives that are, in certain embodiments, adenosine receptor agonists.

    摘要翻译： 公开了制备式A的2-链炔基腺苷衍生物的方法：或其立体异构体，药学上可接受的盐，水合物，溶剂化物，酸盐水合物或同构晶体形式的方法，所述方法包括以下步骤：将2-碘腺嘌呤-5'-N - 乙基脲与式B化合物反应：其中Z是-C（-O）OR或-CH 2 C（-O）R，其中R是C 1〜 优选地，该方法可用于制备在某些实施方案中为腺苷受体激动剂的2-炔基腺苷衍生物。