公开(公告)号：US20240344021A1

公开(公告)日：2024-10-17

申请号：US18750252

申请日：2024-06-21

Applicant: AJINOMOTO CO., INC.

Inventor： Shinya Yamaide ,  Masashi Harada ,  Akari Tashiro ,  Chihiro Tsuji ,  Takuya Higuchi ,  Satoshi Okutani ,  Fumi Ogata ,  Shumpei Furomitsu ,  Masakazu Sugiyama

IPC: C12N5/00

CPC classification number: C12N5/0018 ,  C12N2500/32 ,  C12N2500/60

Abstract: A composition for animal cell culture and techniques relating thereto are provided. A composition for animal cell culture, which contains an amino acid source and α-ketoglutaric acid, and has the following properties: (A) the α-ketoglutaric acid is a salt of α-ketoglutaric acid; and/or (B) the amino acid source is free L-cysteine anhydrate is provided.

公开(公告)号：US11327060B2

公开(公告)日：2022-05-10

申请号：US15938450

申请日：2018-03-28

Applicant: Ajinomoto Co., Inc.

Inventor： Masashi Harada ,  Sachise Karakawa ,  Kazutaka Shimbo ,  Naoyuki Yamada

IPC: G01N30/00 ,  G01N30/88 ,  C07C271/58 ,  C07D401/12 ,  C07D207/46 ,  C07D213/40 ,  G01N30/06 ,  G01N27/62 ,  B01D15/38 ,  C07C233/62 ,  C07B57/00 ,  B01D15/32 ,  C07C51/353 ,  C07C51/47 ,  C07C53/18 ,  C07C269/06 ,  C07C269/08 ,  G01N1/40 ,  G01N30/72

Abstract: Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.

公开(公告)号：US20180217113A1

公开(公告)日：2018-08-02

申请号：US15938450

申请日：2018-03-28

Applicant: Ajinomoto Co., Inc.

Inventor： Masashi Harada ,  Sachise Karakawa ,  Kazutaka Shimbo ,  Naoyuki Yamada

IPC: G01N30/88 ,  C07D207/46 ,  C07D401/12 ,  C07C271/58 ,  C07D213/40 ,  C07C53/18 ,  C07C51/47 ,  G01N1/40 ,  C07C269/08 ,  C07C269/06 ,  C07C51/353 ,  G01N27/62 ,  G01N30/06 ,  G01N30/72 ,  B01D15/32

CPC classification number: G01N30/88 ,  B01D15/327 ,  B01D15/38 ,  C07B57/00 ,  C07B2200/07 ,  C07C51/353 ,  C07C51/47 ,  C07C53/18 ,  C07C233/62 ,  C07C269/06 ,  C07C269/08 ,  C07C271/58 ,  C07D207/46 ,  C07D213/40 ,  C07D401/12 ,  G01N1/405 ,  G01N27/62 ,  G01N30/06 ,  G01N30/7233

Abstract: Enantiomers may be analyzed by: (1) reacting a mixture of a first compound and a second compound that are a pair of enantiomers with an axially chiral compound that is one of a pair of axially chiral isomers, to generate a derivative mixture containing a first derivative obtained by a reaction of the first compound with the axially chiral compound and a second derivative obtained by a reaction of the second compound with the axially chiral compound; (2) separating the first derivative and the second derivative in the derivative mixture; and (3) detecting the separated first derivative and second derivative by mass spectrometry.