公开(公告)号：US20230416793A1

公开(公告)日：2023-12-28

申请号：US18307947

申请日：2023-04-27

申请人： Ajinomoto Co., Inc.

发明人： Seiko Hirano ,  Kota Inoue ,  Kazuyuki Hayashi ,  Kosuke Yokota ,  Mika Moriya ,  Tomoko Suzuki ,  Yoshitomo Kadokura ,  Takeshi Nagahiko ,  Akari Tashiro

IPC分类号： C12P13/14 ,  C12N15/77 ,  C12N9/12 ,  C12N9/16 ,  C12N9/02 ,  C12N9/10 ,  C12N9/04 ,  C12N9/88

CPC分类号： C12P13/14 ,  C12N15/77 ,  C12N9/1217 ,  C12N9/16 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/0006 ,  C12N9/88 ,  C12R2001/15

摘要： Provided is a method of producing an L-amino acid such as L-glutamic acid and the like. An L-amino-acid is produced by cultivating a coryneform bacterium having L-amino acid-producing ability in a culture medium, which has been modified so as to have one or more of the following modifications: (A) a modification for increasing activity of acetate kinase, (B) a modification for increasing activity of fructose-1,6-bisphosphatase, (C) a modification for decreasing activity of pyruvate dehydrogenase, (D) a modification for decreasing activity of aspartate transaminase, and (E) a modification for decreasing activity of malic enzyme; and collecting the L-amino acid from the culture medium and/or the bacterial cells.