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公开(公告)号：US10745725B2
公开(公告)日：2020-08-18
申请号：US15937336
申请日：2018-03-27
申请人： AJINOMOTO CO., INC.
发明人： Kosuke Yokota , Kazuyuki Hayashi
摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an ability to produce an L-amino acid, which has been modified so that the activity of a non-PTS fructose-uptake carrier and the activity of fructokinase are both increased, in a medium containing fructose, and collecting the L-amino acid from the medium or cells of the bacterium.
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公开(公告)号：US20170121743A1
公开(公告)日：2017-05-04
申请号：US15334444
申请日：2016-10-26
申请人： AJINOMOTO CO., INC.
CPC分类号： C12P13/14 , C07K14/34 , C12P13/10 , C12P13/24 , C12Y401/02009
摘要： A method for producing an L-amino acid of glutamate family such as L-glutamic acid is provided. An L-amino acid of glutamate family is produced by culturing a coryneform bacterium having an ability for producing an L-amino acid of glutamate family, which has been modified so that the activity of an α-ketoglutaric acid (α-KG) uptake carrier is increased, in a medium, and collecting the L-amino acid of glutamate family from the medium.
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公开(公告)号：US20130288313A1
公开(公告)日：2013-10-31
申请号：US13938601
申请日：2013-07-10
申请人： Ajinomoto Co., Inc.
发明人： Yuri Nagai , Kazuyuki Hayashi , Takuji Ueda , Yoshihiro Usuda , Kazuhiko Matsui
IPC分类号： C12P13/08
摘要： An L-amino acid is produced by culturing a microorganism belonging to the family Enterobacteriaceae having an L-amino acid-producing ability and modified so that glycerol dehydrogenase and dihydroxyacetone kinase activities are increased, in a medium containing glycerol as a carbon source to produce and accumulate an L-amino acid in the medium or cells, and collecting the L-amino acid from the medium or the cells.
摘要翻译： 通过在含有甘油作为碳源的培养基中培养属于具有L-氨基酸生产能力的肠杆菌科的微生物并进行修饰以使甘油脱氢酶和二羟基丙酮激酶活性增加的L-氨基酸产生， 在培养基或细胞中积累L-氨基酸，并从培养基或细胞中收集L-氨基酸。
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公开(公告)号：US20180282773A1
公开(公告)日：2018-10-04
申请号：US15937336
申请日：2018-03-27
申请人： AJINOMOTO CO., INC.
发明人： Kosuke Yokota , Kazuyuki Hayashi
摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an ability to produce an L-amino acid, which has been modified so that the activity of a non-PTS fructose-uptake carrier and the activity of fructokinase are both increased, in a medium containing fructose, and collecting the L-amino acid from the medium or cells of the bacterium.
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公开(公告)号：US20150307907A1
公开(公告)日：2015-10-29
申请号：US14796326
申请日：2015-07-10
申请人： AJINOMOTO CO., INC.
发明人： Seiko Hirano , Kazuyuki Hayashi
IPC分类号： C12P13/14
摘要： A method for producing an L-amino acid is provided. An L-amino acid is produced by culturing a coryneform bacterium having an L-amino acid-producing ability, which is modified so that the activity of a phosphate transporter is increased, in a medium, and collecting the L-amino acid from the medium.
摘要翻译： 提供了L-氨基酸的制造方法。 通过培养在培养基中培养具有L-氨基酸生产能力的棒状细菌，其被修饰以使磷酸转运蛋白的活性增加，并从培养基中收集L-氨基酸来生产L-氨基酸 。
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公开(公告)号：US10428359B2
公开(公告)日：2019-10-01
申请号：US15717042
申请日：2017-09-27
申请人： AJINOMOTO CO., INC.
发明人： Mika Moriya , Kazuyuki Hayashi , Akari Yokokawa
IPC分类号： C12P13/20 , C07C227/28 , C12P13/08 , C12P13/14 , C07K14/34 , C12N9/88 , C07C229/36 , C12N1/20 , C12N15/66 , C12Q1/686
摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier such as DctA, DcuA, and DcuB is increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
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公开(公告)号：US20230416793A1
公开(公告)日：2023-12-28
申请号：US18307947
申请日：2023-04-27
申请人： Ajinomoto Co., Inc.
发明人： Seiko Hirano , Kota Inoue , Kazuyuki Hayashi , Kosuke Yokota , Mika Moriya , Tomoko Suzuki , Yoshitomo Kadokura , Takeshi Nagahiko , Akari Tashiro
CPC分类号： C12P13/14 , C12N15/77 , C12N9/1217 , C12N9/16 , C12N9/0008 , C12N9/1096 , C12N9/0006 , C12N9/88 , C12R2001/15
摘要： Provided is a method of producing an L-amino acid such as L-glutamic acid and the like. An L-amino-acid is produced by cultivating a coryneform bacterium having L-amino acid-producing ability in a culture medium, which has been modified so as to have one or more of the following modifications: (A) a modification for increasing activity of acetate kinase, (B) a modification for increasing activity of fructose-1,6-bisphosphatase, (C) a modification for decreasing activity of pyruvate dehydrogenase, (D) a modification for decreasing activity of aspartate transaminase, and (E) a modification for decreasing activity of malic enzyme; and collecting the L-amino acid from the culture medium and/or the bacterial cells.
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公开(公告)号：US20180094285A1
公开(公告)日：2018-04-05
申请号：US15717042
申请日：2017-09-27
申请人： AJINOMOTO CO., INC.
发明人： Mika Moriya , Kazuyuki Hayashi , Akari Yokokawa
IPC分类号： C12P13/20 , C12P13/14 , C12P13/08 , C07C227/28
CPC分类号： C12P13/20 , C07C227/28 , C07C229/36 , C07K14/34 , C12N1/20 , C12N9/88 , C12N15/66 , C12P13/08 , C12P13/14 , C12Q1/686
摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier such as DctA, DcuA, and DcuB is increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
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公开(公告)号：US09932614B2
公开(公告)日：2018-04-03
申请号：US15334444
申请日：2016-10-26
申请人： AJINOMOTO CO., INC.
CPC分类号： C12P13/14 , C07K14/34 , C12P13/10 , C12P13/24 , C12Y401/02009
摘要： A method for producing an L-amino acid of glutamate family such as L-glutamic acid is provided. An L-amino acid of glutamate family is produced by culturing a coryneform bacterium having an ability for producing an L-amino acid of glutamate family, which has been modified so that the activity of an α-ketoglutaric acid (α-KG) uptake carrier is increased, in a medium, and collecting the L-amino acid of glutamate family from the medium.
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10.发明授权Method for producing L-amino acid using microorganism having increased phosphate transporter activity 有权使用具有增加的磷酸转运蛋白活性的微生物生产L-氨基酸的方法公开(公告)号：US09506094B2
公开(公告)日：2016-11-29
申请号：US14796326
申请日：2015-07-10
申请人： AJINOMOTO CO., INC.
发明人： Seiko Hirano , Kazuyuki Hayashi
摘要： A method for producing an L-amino acid is provided. An L-amino acid is produced by culturing a coryneform bacterium having an L-amino acid-producing ability, which is modified so that the activity of a phosphate transporter is increased, in a medium, and collecting the L-amino acid from the medium.
摘要翻译： 提供了L-氨基酸的制造方法。 通过培养在培养基中培养具有L-氨基酸生产能力的棒状细菌，其被修饰以使磷酸转运蛋白的活性增加，并从培养基中收集L-氨基酸来生产L-氨基酸 。
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