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公开(公告)号：US07790470B2
公开(公告)日：2010-09-07
申请号：US10588546
申请日：2005-03-23
CPC分类号： B01F5/0057 , B01F1/0022 , B01F5/0206 , B01F2215/0037 , G01N21/03 , G01N21/76 , G01N2035/00544 , Y10T436/25
摘要： A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.
摘要翻译： 能够迅速且容易地搅拌液体样品和试剂的方法包括以下步骤（A）和（B）。 在步骤（A）中，使用包括：具有多个颗粒的液体样品保留部分的细胞; 将液体试样供给口从液体试样供给口供给到液体试样保持部。 在步骤（B）中，液体样品和能够特异性结合分析物的特异性结合物质由于由液体样品供应而导致的液体样品流动引起的颗粒运动而被搅拌至 获得液体混合物。 至少颗粒表面的电荷和特定结合物质的电荷在液体混合物中具有相同的极性。
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公开(公告)号：US20070172961A1
公开(公告)日：2007-07-26
申请号：US10588546
申请日：2005-03-23
IPC分类号： G01N1/00
CPC分类号： B01F5/0057 , B01F1/0022 , B01F5/0206 , B01F2215/0037 , G01N21/03 , G01N21/76 , G01N2035/00544 , Y10T436/25
摘要： A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.
摘要翻译： 能够迅速且容易地搅拌液体样品和试剂的方法包括以下步骤（A）和（B）。 在步骤（A）中，使用包括：具有多个颗粒的液体样品保留部分的细胞; 将液体试样供给口从液体试样供给口供给到液体试样保持部。 在步骤（B）中，液体样品和能够特异性结合分析物的特异性结合物质由于由液体样品供应而导致的液体样品流动引起的颗粒运动而被搅拌至 获得液体混合物。 至少颗粒表面的电荷和特定结合物质的电荷在液体混合物中具有相同的极性。
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公开(公告)号：US07691255B2
公开(公告)日：2010-04-06
申请号：US11579638
申请日：2005-04-22
IPC分类号： G01N27/327 , G01N27/333 , G01N21/00
CPC分类号： G01N33/5302 , G01N21/03 , G01N21/59 , G01N33/48707
摘要： A sensor capable of measuring a plurality of measuring items quickly and accurately, a measuring device, and a measuring method are provided. The sensor includes a sample-holding unit for holding a sample containing an analyte; a sample-supplying port for supplying the sample to the sample-holding unit; a detecting unit for carrying out an electrochemical measurement, the unit being provided in the sample-holding unit; an optical measuring unit for carrying out an optical measurement, the unit being provided in the sample-holding unit; and a reagent-holding unit for holding a reagent for the optical measurement, the unit being provided in the sample-holding unit; wherein in the flowing direction of the sample supplied from the sample-supplying port in sample-holding unit, the sample-supplying port, the detecting unit, and the reagent-holding unit are positioned in the order recited.
摘要翻译： 提供了能够快速准确地测量多个测量项目的传感器，测量装置和测量方法。 传感器包括用于保持含有分析物的样品的样品保持单元; 用于将样品供给到样品保持单元的样品供给口; 用于执行电化学测量的检测单元，该单元设置在样本保持单元中; 用于执行光学测量的光学测量单元，该单元设置在样本保持单元中; 以及用于保持用于光学测量的试剂的试剂保持单元，所述单元设置在所述样品保持单元中; 其中，在从样本保持单元中的样本供给口提供的样本的流动方向上，按照所述的顺序对样本供给口，检测单元和试剂保持单元进行定位。
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公开(公告)号：US20080105566A1
公开(公告)日：2008-05-08
申请号：US11579638
申请日：2005-04-22
CPC分类号： G01N33/5302 , G01N21/03 , G01N21/59 , G01N33/48707
摘要： A sensor capable of measuring a plurality of measuring items quickly and accurately, a measuring device, and a measuring method are provided. The sensor includes a sample-holding unit for holding a sample containing an analyte; a sample-supplying port for supplying the sample to the sample-holding unit; a detecting unit for carrying out an electrochemical measurement, the unit being provided in the sample-holding unit; an optical measuring unit for carrying out an optical measurement, the unit being provided in the sample-holding unit; and a reagent-holding unit for holding a reagent for the optical measurement, the unit being provided in the sample-holding unit; wherein in the flowing direction of the sample supplied from the sample-supplying port in sample-holding unit, the sample-supplying port, the detecting unit, and the reagent-holding unit are positioned in the order recited.
摘要翻译： 提供了能够快速准确地测量多个测量项目的传感器，测量装置和测量方法。 传感器包括用于保持含有分析物的样品的样品保持单元; 用于将样品供给到样品保持单元的样品供给口; 用于执行电化学测量的检测单元，该单元设置在样本保持单元中; 用于执行光学测量的光学测量单元，该单元设置在样本保持单元中; 以及用于保持用于光学测量的试剂的试剂保持单元，所述单元设置在所述样品保持单元中; 其中，在从样本保持单元中的样本供给口提供的样本的流动方向上，按照所述的顺序对样本供给口，检测单元和试剂保持单元进行定位。
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5.发明申请Method of immunoreaction measurement and, for use therein, reagent, kit and optical cell 审中-公开免疫反应测定方法，用于其中的试剂，试剂盒和光学电池公开(公告)号：US20060281132A1
公开(公告)日：2006-12-14
申请号：US10573382
申请日：2004-09-22
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N33/84
摘要： In the present invention, there is provided a method for measuring, under an acidic pH condition, a subject substance in a specimen. The method includes: step A for forming a reaction system by mixing the specimen and an antibody against the subject substance in the specimen; and step B for measuring an antigen-antibody reaction in the reaction system, wherein a pH of the reaction system is set to be acidic, and the relationship between a pI of the antibody and the pH of the reaction system is set to be pI>pH. According to the present invention, a measurement accuracy can be enhanced in an immune measurement reaction system basically using an acidic buffer solution, particularly in a region of low concentration for an antigen.
摘要翻译： 在本发明中，提供了在酸性pH条件下测定试样中的被检物质的方法。 该方法包括：步骤A，用于通过将样品与针对样品中的被检物质的抗体混合形成反应体系; 和步骤B，用于测量反应体系中的抗原 - 抗体反应，其中反应体系的pH设定为酸性，并且将抗体的pI与反应体系的pH之间的关系设定为pI> pH值。 根据本发明，在基本上使用酸性缓冲溶液的免疫测定反应体系中，特别是抗原浓度低的区域，可以提高测定精度。
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公开(公告)号：US20050228242A1
公开(公告)日：2005-10-13
申请号：US11095543
申请日：2005-04-01
CPC分类号： A61B5/00 , A61B5/6887 , A61B5/7275 , G16H50/20 , G16H50/30
摘要： A vital data utilization system that stores and utilizes measured vital data, including: a vital data measurement unit 101 that measures the vital data of a subject; a time measurement unit 102 that stores the information on the measurement date and time at which the vital data was measured; a subject information storage unit 103 on which subject information including the vital data and the information on the measurement date and time that are associated with each other are stored; a reference information storage unit 104 on which reference information including the vital data and the information on the measurement date and time are stored; a subject variation pattern generation unit that extracts, from the subject information storage unit, the subject information in a specific period that lasts until the vital data that satisfies a first predetermined condition is measured, in the case of the measured vital data satisfies the first predetermined condition; a reference variation pattern generation unit 116 that extracts, from the reference information storage unit, the vital data that satisfies the first predetermined condition, extracts, from the reference information storage unit, the reference information in the specific period that lasts until the vital data is measured, and generate a reference variation pattern, and a prediction variation pattern generation unit 105 that generates a prediction variation pattern using the reference information after this reference variation pattern, in the case where the comparison result of the reference variation pattern and the subject variation pattern satisfies the second predetermined condition.
摘要翻译： 一种重要的数据利用系统，其存储和利用测量的重要数据，包括：测量对象的重要数据的重要数据测量单元101; 时间测量单元102，其存储关于测量生命数据的测量日期和时间的信息; 主题信息存储单元103，其上存储包括重要数据的对象信息和关于彼此关联的测量日期和时间的信息; 参考信息存储单元104，其上存储包括重要数据的参考信息和关于测量日期和时间的信息; 被摄体变化图案生成单元，从被检体信息存储单元取出在所测量的生命体数据满足第1规定条件的情况下，持续到持续至满足第1规定条件的重要数据为止的特定期间的被检体信息 条件; 从参考信息存储单元提取满足第一预定条件的重要数据的参考变化模式生成单元116从参考信息存储单元中提取持续到生命数据的特定时段内的参考信息 测量并产生参考变化模式;以及预测变化模式生成单元105，其在参考变化模式和对象变化模式的比较结果的情况下，使用参考变化模式之后的参考信息生成预测变化模式 满足第二预定条件。
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公开(公告)号：US07553676B2
公开(公告)日：2009-06-30
申请号：US11507011
申请日：2006-08-21
IPC分类号： G01N33/553
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.
摘要翻译： 本发明的用于测量样品中目标物质含量的特定偶合反应测量方法包括以下步骤：（a）构建包含样品和磁性颗粒的反应体系，其上特异性偶联物质与该物质偶合 物质被固定; （b）测量反应体系的光学特性; 和（c）通过利用磁力从反应体系中除去包含被检体，特定偶联物质和磁性粒子的凝集络合物。
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公开(公告)号：US20050009102A1
公开(公告)日：2005-01-13
申请号：US10886640
申请日：2004-07-09
申请人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
发明人： Tatsurou Kawamura , Keiko Yugawa , Akihito Kamei
IPC分类号： G01N21/82 , G01N33/52 , G01N33/53 , G01N33/536 , G01N33/557
CPC分类号： G01N33/557
摘要： According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of an antigen contained in a sample solution is determined from the maximum value and/or minimum value of turbidity level detected in the observation of the transient phenomenon of turbidity, elapsed time when the maximum and/or minimum value is observed, and turbidity level.
摘要翻译： 根据本发明，可以在没有稀释步骤等的情况下实现样品溶液中的抗原的可测量的浓度范围的扩大。 样品溶液中含有的抗原浓度是根据观察浊度的瞬时现象，观察到最大值和/或最小值时的经过时间以及浊度的最大值和/或最小值来确定的。 水平。
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9.发明申请Biological information utilization system, biological information utilization method, program and recording medium 审中-公开生物信息利用系统，生物信息利用方法，程序和记录介质公开(公告)号：US20060288253A1
公开(公告)日：2006-12-21
申请号：US10559872
申请日：2004-06-10
申请人： Tatsurou Kawamura , Akihito Kamei
发明人： Tatsurou Kawamura , Akihito Kamei
IPC分类号： G06F11/00
CPC分类号： G06F19/3418 , G06Q50/24 , G16H10/20 , G16H10/60
摘要： In a vital data utilization system, measurement systems include a measurement unit for measuring the vital data of subjects, a clock unit for detecting each measurement time at which vital data is measured and a communication unit for sending the vital data including measurement time to a server, a server includes a communication unit for receiving sets of vital data from measurement systems, a vital data storage unit in which vital data are stored, a value-added information making unit for making the value-added information indicating the changes over time of average values of subjects' vital data in a predetermined geographical area based on the vital data stored in the vital data storage unit and a communication unit for providing the made value-added information to the measurement systems and the PCs of service destinations, and PCs output the provided value-added information.
摘要翻译： 在重要的数据利用系统中，测量系统包括用于测量被摄体的重要数据的测量单元，用于检测测量重要数据的每个测量时间的时钟单元和用于将包括测量时间的重要数据发送到服务器的通信单元 服务器包括用于从测量系统接收重要数据集的通信单元，其中存储重要数据的重要数据存储单元，增值信息制造单元，用于使增值信息指示随时间变化的增长信息 基于存储在重要数据存储单元中的重要数据的预定地理区域中的受试者的重要数据的值以及用于将所提供的增值信息提供给测量系统和服务目的地的PC的通信单元，并且PC输出 提供增值信息。
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公开(公告)号：US20060281195A1
公开(公告)日：2006-12-14
申请号：US11507011
申请日：2006-08-21
IPC分类号： C12M1/34 , G01N33/551
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.
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