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公开(公告)号：US08865153B2
公开(公告)日：2014-10-21
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , C07K14/705 , G01N33/574 , A61K35/76 , C12N15/39 , A61K38/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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2.发明申请公开(公告)号：US20090155287A1
公开(公告)日：2009-06-18
申请号：US12080766
申请日：2008-04-04
申请人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/76 , A61K39/395 , A61K39/00 , A61P35/04
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要翻译： 提供了修饰的病毒和用于制备修饰的病毒的方法。 提供含有病毒的疫苗。 病毒可以用于治疗诸如增殖性和炎性疾病（包括癌症）的疾病的方法，以及作为抗肿瘤和/或抗血管生成剂。 病毒也可用于诊断方法。
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公开(公告)号：US20130129614A9
公开(公告)日：2013-05-23
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
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公开(公告)号：US20090117034A1
公开(公告)日：2009-05-07
申请号：US12157960
申请日：2008-06-13
申请人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
IPC分类号： A61K51/02 , C12N7/01 , A61K35/76 , A61K49/04 , A61K39/395 , A61P35/00 , A61P35/04 , A61P35/02 , A61B10/00 , A61K49/00 , A61K49/06 , A61K39/285
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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公开(公告)号：US08852927B2
公开(公告)日：2014-10-07
申请号：US12660314
申请日：2010-02-23
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N15/39 , G01N33/574 , C12N7/00 , A61K35/76 , C07K14/705 , A61K38/00
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
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6.发明申请公开(公告)号：US20130273007A1
公开(公告)日：2013-10-17
申请号：US13986866
申请日：2013-06-12
申请人： Aladar A. Szalay , Yong A. Yu , Nanhai Chen , Qian Zhang
发明人： Aladar A. Szalay , Yong A. Yu , Nanhai Chen , Qian Zhang
IPC分类号： A61K35/76
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Lister strain vaccinia viruses that are encode a modified A34R gene resulting in increased extracellular enveloped virus (EEV) form of the virus and/or increased resistance of the virus to neutralizing antibodies. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 编码修饰的A34R基因的Lister菌株痘苗病毒导致增加的细胞外包膜病毒（EEV）形式的病毒和/或增加的病毒抗中和抗体。 病毒可以用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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公开(公告)号：US20110293527A1
公开(公告)日：2011-12-01
申请号：US13136519
申请日：2011-08-02
申请人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
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公开(公告)号：US20100233078A1
公开(公告)日：2010-09-16
申请号：US12660314
申请日：2010-02-23
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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公开(公告)号：US20090136917A1
公开(公告)日：2009-05-28
申请号：US12288887
申请日：2008-10-24
申请人： Aladar A. Szalay , Yong A. Yu , Nanhai Chen , Alexa Frentzen , Qian Zhang
发明人： Aladar A. Szalay , Yong A. Yu , Nanhai Chen , Alexa Frentzen , Qian Zhang
CPC分类号： G01N33/5011 , A61K35/768 , A61K38/45 , C07K14/005 , C12N7/00 , C12N2710/24122 , C12N2710/24132 , C12N2710/24161 , A61K2300/00
摘要： Diagnostic methods and compositions associated with viral therapy are provided. In particular, methods, compositions, and kits to measure markers and therapeutic indicator predictive of viral efficacy in antitumor therapy are provided. Therapeutic viruses and combinations and kits for use in the practicing the methods also are provided.
摘要翻译： 提供与病毒治疗相关的诊断方法和组合。 特别地，提供了用于测量标志物的方法，组合物和试剂盒以及预防抗肿瘤治疗中的病毒功效的治疗指示剂。 还提供了用于实践方法的治疗病毒和组合和试剂盒。
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10.发明申请公开(公告)号：US20090098529A1
公开(公告)日：2009-04-16
申请号：US11975088
申请日：2007-10-16
申请人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.
摘要翻译： 提供了修饰或减毒的病毒以及用于制备修饰的病毒和调节衰减的方法。 提供含有病毒的疫苗。 病毒可以用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。 病毒也可用于诊断方法。
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