公开(公告)号：US20080096857A1

公开(公告)日：2008-04-24

申请号：US10588419

申请日：2005-02-08

申请人： Alain H. Curaudeau ,  Herma C. Neyndorff ,  Jing-Song Tao ,  Julia G. Levy ,  David W.C. Hunt ,  Morgan Chun Lam ,  Patrick Mark Curry ,  Valery Rubinchik

发明人： Alain H. Curaudeau ,  Herma C. Neyndorff ,  Jing-Song Tao ,  Julia G. Levy ,  David W.C. Hunt ,  Morgan Chun Lam ,  Patrick Mark Curry ,  Valery Rubinchik

IPC分类号： A61K31/555 ,  A61K31/5415 ,  A61K31/409 ,  A61K31/195

CPC分类号： A61K31/07 ,  A61K31/203 ,  A61K31/409 ,  A61K31/555 ,  A61K41/0061 ,  A61K41/0071 ,  A61K41/0076 ,  A61N5/062

摘要： The present method involves the photodynamic treatment of hyperactive gland disorders. The method involves the topical administration of a photosensitizer composition comprising hydrophobic and/or lipophilic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to affected skin and subsequent exposure of that skin to energy of a wavelength capable of activating the photosensitizer.

摘要翻译： 本方法涉及光动力学治疗多发性腺体疾病。 该方法包括局部施用包含疏水性和/或亲脂性绿色卟啉如雷米他芬，聚乙二醇和皮肤渗透增强剂如油醇和TRANSCUTOL TM的光敏剂组合物，以影响皮肤并随后暴露于皮肤的能量 波长能够激活光敏剂。

公开(公告)号：US20100056982A1

公开(公告)日：2010-03-04

申请号：US10588571

申请日：2005-02-04

申请人： Alain H. Curaudeau ,  Herma C. Neyndorff ,  Jinj-Song Tao ,  Morgan Chun Lam ,  Patrick Mark Curry ,  Valery Rubinchik ,  David W.C. Hunt

发明人： Alain H. Curaudeau ,  Herma C. Neyndorff ,  Jinj-Song Tao ,  Morgan Chun Lam ,  Patrick Mark Curry ,  Valery Rubinchik ,  David W.C. Hunt

IPC分类号： A61K41/00 ,  A61M37/00 ,  A61N5/06

CPC分类号： A61K31/07 ,  A61K31/203 ,  A61K31/409 ,  A61K31/555 ,  A61K41/0061 ,  A61K41/0071 ,  A61K41/0076 ,  A61N5/062

摘要： The present method involves the photodynamic treatment of acne vulgaris. The method involves the topical administration of a photosensitizer composition comprising hydrophobic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to acne-affected skin and subsequent exposure of that skin to energy of a wavelength of activating the photosensitizer.

摘要翻译： 本方法涉及寻常痤疮的光动力治疗。 该方法包括局部施用包含疏水性绿色卟啉如雷米普芬，聚乙二醇和皮肤渗透促进剂如油醇和TRANSCUTOL TM的光敏剂组合物，以治疗受痤疮影响的皮肤，并随后将该皮肤暴露于激活波长的波长的能量 光敏剂

公开(公告)号：US5597722A

公开(公告)日：1997-01-28

申请号：US274507

申请日：1994-07-13

申请人： John Chapman ,  Patricia M. Logan ,  Herma C. Neyndorff ,  Janice North

发明人： John Chapman ,  Patricia M. Logan ,  Herma C. Neyndorff ,  Janice North

IPC分类号： A61L2/00 ,  C12N7/06 ,  A01N1/02

CPC分类号： A61L2/0011 ,  A01N1/0215 ,  A01N1/0294

摘要： The present invention provides a method for inactivating pathogens in a body fluid, such as plasma, red cells, platelets, leukocytes, and bone marrow. The present invention minimizes adverse effects caused by the photosensitive agents while retaining the disinfecting activity of such agents and processes. Pursuant to the present invention, prior to irradiating a body fluid including a photoactive drug, the extracellular fluid, which in the case of blood components includes plasma proteins is at least substantially reduced. Additionally, after the irradiation process, the resultant body fluid is prevented from contacting additional extracellular fluid, e.g., plasma proteins, for a predefined period.

摘要翻译： 本发明提供了灭活体液如血浆，红细胞，血小板，白细胞和骨髓中的病原体的方法。 本发明最小化由感光剂引起的不利影响，同时保持这些试剂和方法的消毒活性。 根据本发明，在照射包含光活性药物的体液之前，在血液成分包括血浆蛋白质的情况下的细胞外液体至少显着降低。 此外，在照射过程之后，防止所得体液接触另外的细胞外液，例如血浆蛋白，预定时间。

公开(公告)号：US5360734A

公开(公告)日：1994-11-01

申请号：US10469

申请日：1993-01-28

申请人： John Chapman ,  Patricia M. Logan ,  Herma C. Neyndorff ,  Janice North

发明人： John Chapman ,  Patricia M. Logan ,  Herma C. Neyndorff ,  Janice North

IPC分类号： A01N1/02 ,  A61K31/34 ,  A61K31/40 ,  A61K31/54 ,  A61K41/00 ,  A61L2/00 ,  A61P31/12 ,  C12N7/06

CPC分类号： A61L2/0011 ,  A01N1/0215 ,  A61K41/0071

摘要： The present invention provides a method for inactivating pathogens in a body fluid, such as plasma, red cells, platelets, leukocytes, and bone marrow. The present invention minimizes adverse effects caused by the photosensitive agents while retaining the disinfecting activity of such agents and processes. Pursuant to the present invention, prior to irradiating a body fluid including a photoactive drug, the extracellular fluid, which in the case of blood components includes plasma proteins is at least substantially reduced. Additionally, after the irradiation process, the resultant body fluid is prevented from contacting additional extracellular fluid, e.g., plasma proteins, for a predefined period.

摘要翻译： 本发明提供了灭活体液如血浆，红细胞，血小板，白细胞和骨髓中的病原体的方法。 本发明最小化由感光剂引起的不利影响，同时保持这些试剂和方法的消毒活性。 根据本发明，在照射包含光活性药物的体液之前，在血液成分包括血浆蛋白质的情况下的细胞外液体至少显着降低。 此外，在照射过程之后，防止所得体液接触另外的细胞外液，例如血浆蛋白，预定时间。