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    Allylaminoesters and their application in therapeutics
    1.
    发明授权
    Allylaminoesters and their application in therapeutics 失效
    烯丙基氨基酯及其在治疗中的应用

    公开(公告)号：US5472970A

    公开(公告)日：1995-12-05

    申请号：US309004

    申请日：1994-09-19

    申请人： Alain P. Calvet ,  Agnes G. Grouhel ,  Jean-Louis Junien

    发明人： Alain P. Calvet ,  Agnes G. Grouhel ,  Jean-Louis Junien

    IPC分类号： C07C215/28 ,  C07C219/22 ,  C07D213/79 ,  C07D213/80 ,  A61K31/22 ,  A61K31/235 ,  A61K31/44 ,  C07D213/55

    CPC分类号： C07D213/79 ,  C07C215/28 ,  C07C219/22 ,  C07D213/80

    摘要： Allylaminoesters of the formula (I): ##STR1## in which: R.sub.1 is H or low-molecular-weight alkyl,R.sub.2 is low-molecular-weight alkyl, cycloalkyl, or low-molecular-weight phenylcycloalkyl, pyridyl or phenyl, low-molecular-weight phenylalkyl, low-molecular-weight diphenylalkyl, low-molecular-weight phenylalkenyl, in which the phenyl cycle may be mono-, di- or trisubstituted by chlorine atoms, low-molecular-weight alkyl radicals, low-molecular-weight alkoxy, or trifluoromethyl, acetamide or acetyloxy radicals, their racemic forms, their (S) enantiomers and their addition salts. Also, antiallergic drugs containing the same.

    摘要翻译： 式（I）的烯丙基氨基酯：其中：R 1是H或低分子量烷基，R 2是低分子量烷基，环烷基或低分子量苯基环烷基，吡啶基或苯基 ，低分子量苯基烷基，低分子量二苯基烷基，低分子量苯基烯基，其中苯基周期可以被氯原子单，二或三取代，低分子量烷基，低分子量苯基烷基， 分子量的烷氧基或三氟甲基，乙酰胺或乙酰氧基，它们的外消旋体，它们的（S）对映体及其加成盐。 而且，含有相同的抗过敏药物。

    Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
    6.
    发明授权
    Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments 失效
    甾族酯在17位酯化并在21位硫酯化，其制备方法及其用作药物

    公开(公告)号：US4427671A

    公开(公告)日：1984-01-24

    申请号：US397715

    申请日：1982-07-13

    申请人： Dieran R. Torossian ,  Gilbert G. Aubard ,  Claude P. Roux ,  Agnes G. Grouhel

    发明人： Dieran R. Torossian ,  Gilbert G. Aubard ,  Claude P. Roux ,  Agnes G. Grouhel

    IPC分类号： A61K31/57 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07J31/00 ,  A61K31/56 ,  C07J7/00

    CPC分类号： C07J31/006 ,  Y10S514/826

    摘要： Compounds of formula: ##STR1## wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen, T and U, independently of each other, represent hydrogen atoms or together form a double bond, V is a hydrogen atom or a methyl group at the .alpha.-position, W is a hydrogen atom or a halogen atom at the .alpha.-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z.sub.1 is a hydrogen atom, a methyl group at the .alpha.- or .beta.-position, while Z.sub.2 is a hydrogen atom, or Z.sub.1 and Z.sub.2 together form a methylene group. These compounds have anti-inflammatory activity.

    摘要翻译： 其中A和B各自独立地表示具有1至6个碳原子的直链或支链烷基或任选被1至6个碳原子的烷基单取代或多取代的苯基， 6个碳原子，具有1至6个碳原子的烷氧基或卤素，T和U彼此独立地表示氢原子或一起形成双键，V是氢原子或α-位上的甲基， W是α位上的氢原子或卤素原子，X是β位上的羟基，Y是氢原子，X和Y可以一起代表氧原子，Z1是氢原子， 甲基在α或β-位，而Z 2是氢原子，或Z 1和Z 2一起形成亚甲基。 这些化合物具有抗炎活性。