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公开(公告)号:US20050059726A1
公开(公告)日:2005-03-17
申请号:US10499529
申请日:2002-12-20
申请人: Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
发明人: Alan Borthwick , Chuen Chan , Henry Kelly , Nigel King , Savvas Kleanthous , Andrew Mason , Ivan Pinto , Derek Pollard , Stefan Senger , Gita Shah , Nigel Watson , Robert Young
IPC分类号: A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4365 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/546 , A61P3/00 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P11/08 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P41/00 , A61P43/00 , C07D207/26 , C07D207/273 , C07D401/12 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/404 , C07D43/02 , C07D45/02 , C07D49/02
CPC分类号: C07D207/273 , C07D401/12 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04
摘要: The present invention relates to novel compounds and pharmaceutically acceptable derivatives thereof. The invention also relates to processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and to the use of compounds in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译: 本发明涉及新化合物及其药学上可接受的衍生物。 本发明还涉及制备化合物的方法,含有该化合物的药物组合物,以及化合物在医药中的用途,特别是在改善指定因子Xa抑制剂的临床病症中。
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2.
公开(公告)号:US20070185162A1
公开(公告)日:2007-08-09
申请号:US11630100
申请日:2005-06-21
申请人: Alan Borthwick , Deidre Mary Hickey , John Liddle , Andrew Mason , Derek Pollard , Steven Sollis
发明人: Alan Borthwick , Deidre Mary Hickey , John Liddle , Andrew Mason , Derek Pollard , Steven Sollis
IPC分类号: A61K31/445 , C07D241/04
CPC分类号: C07D401/06 , C07D403/06 , C07D413/06
摘要: Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-ethylpropyl, R3 is a heterocyclic group optionally substituted by one or more C1-6 alkyl groups, R4 represents methyl and R5 represents hydrogen or methyl and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
摘要翻译: 其中R 1是2-二氢茚基,R 2的式(I)化合物是1-乙基丙基,R 3是任选取代的杂环基 通过一个或多个C 1-6烷基,R 4代表甲基,R 5表示氢或甲基,其药学上可接受的衍生物被描述 ,其制备方法,含有它们的药物组合物及其在医药中的用途,特别是其作为催产素拮抗剂的用途。
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