公开(公告)号：US20130209490A1

公开(公告)日：2013-08-15

申请号：US13852079

申请日：2013-03-28

申请人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Lu ,  Jing Wu

发明人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Lu ,  Jing Wu

IPC分类号： A61K38/18 ,  A61K38/16 ,  A61K31/7088 ,  A61K45/06 ,  A61K39/395 ,  G01N33/50

CPC分类号： A61K38/1875 ,  A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61K45/06 ,  G01N33/5091 ,  G01N33/74 ,  G01N2333/495 ,  G01N2800/7052 ,  A61K2300/00

摘要： The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.

摘要翻译： 本发明提供使用BMP9和/或BMP10拮抗剂抑制纤维化的新方法，以及治疗或抑制纤维化病症的方法。 本发明还提供了通过检测BMP9和/或BMP10的水平来评估受试者是否具有发展为纤维化疾病的风险的方法。 还提供了通过检测和比较BMP9和BMP10的预处理水平与BMP9和BMP10的后处理水平来评估治疗方案用于治疗纤维化病症的功效的方法。

公开(公告)号：US20160228509A9

公开(公告)日：2016-08-11

申请号：US13852079

申请日：2013-03-28

申请人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Lu ,  Jing Wu

发明人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Lu ,  Jing Wu

IPC分类号： A61K38/18 ,  A61K38/16 ,  A61K31/7088 ,  A61K45/06 ,  A61K39/395 ,  G01N33/50

CPC分类号： A61K38/1875 ,  A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61K45/06 ,  G01N33/5091 ,  G01N33/74 ,  G01N2333/495 ,  G01N2800/7052 ,  A61K2300/00

摘要： The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.

公开(公告)号：US20120183543A1

公开(公告)日：2012-07-19

申请号：US13319133

申请日：2010-05-07

申请人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett

发明人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K38/02 ,  A61K31/7105 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/566 ,  A61P9/00 ,  A61P11/00 ,  A61P1/18 ,  A61P1/16 ,  A61P13/12 ,  A61P21/00 ,  A61P17/00 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  A61P37/06 ,  A61P13/00 ,  A61P35/00 ,  C12N5/071

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.

摘要翻译： 本发明提供使用BMP9和/或BMP10拮抗剂抑制纤维化的新方法，以及治疗或抑制纤维化病症的方法。 本发明还提供了通过检测BMP9和/或BMP10的水平来评估受试者是否具有发展为纤维化疾病的风险的方法。 进一步提供了通过检测和比较BMP9和BMP10的预处理水平与BMP9和BMP10的后处理水平来评估治疗方案治疗纤维化病症的功效的方法。

公开(公告)号：US08563254B2

公开(公告)日：2013-10-22

申请号：US12905273

申请日：2010-10-15

申请人： Michaela Bowden ,  Alan Buckler ,  Chantale T. Guy

发明人： Michaela Bowden ,  Alan Buckler ,  Chantale T. Guy

IPC分类号： G01N33/53 ,  A61K31/16

CPC分类号： G01N33/57407 ,  G01N2333/4703 ,  G01N2333/5421 ,  G01N2333/912 ,  G01N2500/00 ,  G01N2800/52

摘要： The present invention provides novel biomarkers, and methods of using said biomarkers, for assessing the efficacy of a treatment regimen for treating cancer in a subject, particularly for treating cancer via Hsp90 inhibition. The present invention also provides methods of identifying test agents capable of treating cancer, particularly in the case of cancers characterized by high levels of IL-8.

摘要翻译： 本发明提供新的生物标志物和使用所述生物标志物的方法，用于评估治疗方案用于治疗受试者的癌症的功效，特别是通过Hsp90抑制治疗癌症。 本发明还提供鉴定能够治疗癌症的试验剂的方法，特别是在以高水平的IL-8为特征的癌症的情况下。