公开(公告)号：US20050033202A1

公开(公告)日：2005-02-10

申请号：US10822437

申请日：2004-04-12

申请人： Alan Chow ,  George McLean ,  Vincent Chow ,  Jay Cech ,  Christopher Bonner ,  Vladimir Gelfandbein

发明人： Alan Chow ,  George McLean ,  Vincent Chow ,  Jay Cech ,  Christopher Bonner ,  Vladimir Gelfandbein

IPC分类号： A61H1/00 ,  A61H5/00 ,  A61N1/05 ,  A61N1/36 ,  A61N2/06 ,  A61N2/12

CPC分类号： A61N1/36046 ,  A61H5/00 ,  A61N1/0543 ,  A61N2/06 ,  A61N2/12

摘要： Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.

摘要翻译： 提供用于治疗退行性视网膜疾病的机械活化物体或装置。 这样的装置将机械力施加到眼睛的组织以实现治疗，并且被配置为在眼睛中或眼睛上进行慢性植入（从而施加慢性刺激/刺激）。 所述装置可以被配置为与眼睛的视网膜接触，优选地定位在视网膜下空间中。 各种实施例包括构造成用于与眼睛的至少一部分慢性接触的移动构件，该移动构件由致动器致动。 在一些实施例中，致动器可以相对于移动构件向远侧定位。 或者，移动构件可以由主体构件支撑，其可选地还支撑致动器。

公开(公告)号：US20060142818A1

公开(公告)日：2006-06-29

申请号：US11301352

申请日：2005-12-12

申请人： Alan Chow ,  Vincent Chow

发明人： Alan Chow ,  Vincent Chow

IPC分类号： A61N1/18

CPC分类号： A61F9/0017 ,  A61N1/0543 ,  A61N1/36046

摘要： Methods of using electrical stimulation by itself or in conjunction with growth factors to treat and prevent visual loss due to choroidal, retinal pigment epithelial and/or neuroretinal cell degeneration and dysfunction are presented.

公开(公告)号：US20060142857A1

公开(公告)日：2006-06-29

申请号：US11293871

申请日：2005-12-02

申请人： Alan Chow ,  Vincent Chow

发明人： Alan Chow ,  Vincent Chow

IPC分类号： A61F2/16

CPC分类号： A61N1/0543 ,  A61F9/08 ,  A61N1/36046

摘要： An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space.

摘要翻译： 人眼视网膜装置植入视网膜视网膜失明者中的视网膜视网膜中，通过电刺激视网膜的剩余活细胞诱导人工视觉。 人造视网膜装置包括优选放置在视网膜下空间中的刺激电极单元。

公开(公告)号：US5895415A

公开(公告)日：1999-04-20

申请号：US465766

申请日：1995-06-06

申请人： Vincent Chow ,  Alan Y. Chow

发明人： Vincent Chow ,  Alan Y. Chow

IPC分类号： A61F9/08 ,  A61N1/05 ,  A61N1/36 ,  A61N1/18

CPC分类号： A61N1/05 ,  A61F9/08 ,  A61N1/36046

摘要： An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the MMRI-4s, the nature of induced retinal images may be modulated and improved. An Adaptive Imaging Retinal Stimulation System (AIRES), with a Projection and Tracking Optical System (PTOS), which may be worn as a headset is used for this purpose, and is also disclosed. Color images may even be induced by programming the stimulating pulse durations and frequencies of the AIRES system.

摘要翻译： 公开了一种人造视网膜装置及其功能的刺激和调节方法。 人造视网膜装置由多个多相微光二极管子单元组成。 在因视网膜外层损伤而失明的人中，当手术植入视网膜内空间时，多个这样的装置可以允许有用的形成的人造视觉发展。 称为MMRI-4的一种装置将光转换成电流以刺激视网膜。 MMRI-4的四个微光二极管子单元被定向为使得MMRI-4的每个扁平侧具有PiN配置中的两个亚基和NiP配置中的两个亚基。 通过将实际或计算机控制的可见光图像和计算机控制的红外光图像或照明同时或快速交替地投射到MMRI-4上，可以调制和改善诱导的视网膜图像的性质。 使用具有投影和跟踪光学系统（PTOS）的自适应成像视网膜刺激系统（AIRES）可以作为耳机佩戴，并且还被公开。 甚至可以通过编程AIRES系统的刺激脉冲持续时间和频率来诱导彩色图像。

公开(公告)号：US5091642A

公开(公告)日：1992-02-25

申请号：US522164

申请日：1990-05-11

申请人： Vincent Chow ,  Byron Denenberg

发明人： Vincent Chow ,  Byron Denenberg

IPC分类号： G01N21/78

CPC分类号： G01N21/783

摘要： A monitor for the detection of a target gas by sensing the color change of a colorimetric indicator material. The monitor includes a light detector positioned and having a surface oriented to receive light reflected from the colorimetric indicator material and a light source positioned between the colorimetric indicator material and the light detector and oriented to provide illumination to the colorimetric indicator material but not to the light detector.

摘要翻译： 用于通过感测比色指示剂材料的颜色变化来检测目标气体的监视器。 该监视器包括一个光检测器，其定位并具有被定向成接收从比色指示剂材料反射的光的表面和位于比色指示剂材料和光检测器之间的光源，并定向成向比色指示剂材料提供照明但不对光 探测器。

公开(公告)号：US09526778B2

公开(公告)日：2016-12-27

申请号：US13377070

申请日：2009-06-15

申请人： Sylvie Alonso ,  Rui Li ,  Vincent Chow ,  Camille Locht

发明人： Sylvie Alonso ,  Rui Li ,  Vincent Chow ,  Camille Locht

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/10 ,  A61K39/02 ,  A61K39/12

CPC分类号： A61K39/099 ,  A61K9/0043 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/543 ,  A61K2039/55566 ,  A61K2039/58 ,  C12N2760/16134

摘要： The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.

摘要翻译： 本发明涉及组合物和疫苗，其包括用于治疗或预防哺乳动物流感感染的突变的博德特氏菌属菌株。 此外，本发明还提供了使用组合物或疫苗来保护哺乳动物免受流感感染和/或在哺乳动物中引发针对流感病毒的免疫应答的方法。

公开(公告)号：US07139612B2

公开(公告)日：2006-11-21

申请号：US10600404

申请日：2003-06-20

申请人： Vincent Chow ,  Alan Y. Chow

发明人： Vincent Chow ,  Alan Y. Chow

IPC分类号： A61N1/18

CPC分类号： A61N1/0543 ,  A61F9/08 ,  A61N1/05 ,  A61N1/36046

摘要： An artificial retina device and a retinal stimulation system and method for stimulating and modulating its function is disclosed. The artificial retina device includes multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the artificial retina device, the nature of induced retinal images may be modulated and improved. The retinal stimulation system may be worn as a headset. Color images may be induced by programming the stimulating pulse durations and frequencies of the stimulation.

摘要翻译： 公开了用于刺激和调节其功能的人造视网膜装置和视网膜刺激系统和方法。 人造视网膜装置包括多相微光电二极管子单元。 在因视网膜外层损伤而失明的人中，当手术植入视网膜内空间时，多个这样的装置可以允许有用的形成的人造视觉发展。 通过将实际或计算机控制的可见光图像和计算机控制的红外光图像或照明同时或快速交替地投射到人造视网膜装置上，可以调制和改善诱导的视网膜图像的性质。 视网膜刺激系统可以作为耳机佩戴。 可以通过对刺激的刺激脉冲持续时间和频率进行编程来诱导彩色图像。

公开(公告)号：US06230057B1

公开(公告)日：2001-05-08

申请号：US09100336

申请日：1998-03-26

申请人： Vincent Chow ,  Alan Y. Chow

发明人： Vincent Chow ,  Alan Y. Chow

IPC分类号： A61N118

CPC分类号： A61N1/0543 ,  A61F9/08 ,  A61N1/05 ,  A61N1/36046

摘要： An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. Filter layers disposed on the PiN configuration will allow visible light to induce a PiN current, and filter layers disposed on the NiP configuration will allow infrared light to induce a NiP current. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the MMRI-4s, the nature of induced retinal images may be modulated and improved. An Adaptive Imaging Retinal Stimulation System (AIRES), with a Projection and Tracking Optical System (PTOS), which may be worn as a headset is used for this purpose, and is also disclosed. Color images may even be induced by programming the stimulating pulse durations and frequencies of the AIRES system.

摘要翻译： 公开了一种人造视网膜装置及其功能的刺激和调节方法。 人造视网膜装置由多个多相微光二极管子单元组成。 在因视网膜外层损伤而失明的人中，当手术植入视网膜内空间时，多个这样的装置可以允许有用的形成的人造视觉发展。 称为MMRI-4的一种装置将光转换成电流以刺激视网膜。 MMRI-4的四个微光二极管子单元被定向为使得MMRI-4的每个扁平侧具有PiN配置中的两个亚基和NiP配置中的两个亚基。 设置在PiN配置上的滤光层将允许可见光诱导PiN电流，并且设置在NiP配置上的滤光层将允许红外光诱导NiP电流。 通过将实际或计算机控制的可见光图像和计算机控制的红外光图像或照明同时或快速交替地投射到MMRI-4上，可以调制和改善诱导的视网膜图像的性质。 使用具有投影和跟踪光学系统（PTOS）的自适应成像视网膜刺激系统（AIRES）可以作为耳机佩戴，并且还被公开。 甚至可以通过编程AIRES系统的刺激脉冲持续时间和频率来诱导彩色图像。

公开(公告)号：US5397350A

公开(公告)日：1995-03-14

申请号：US56672

申请日：1993-05-03

申请人： Alan Y. Chow ,  Vincent Chow

发明人： Alan Y. Chow ,  Vincent Chow

IPC分类号： A61F9/007 ,  A61F9/08 ,  A61N1/36 ,  H01L27/146 ,  A61N1/00 ,  A61B17/00 ,  A61F2/14

CPC分类号： A61N1/0543 ,  A61F9/00727 ,  A61F9/08 ,  H01L27/14643 ,  A61N1/36046

摘要： Microscopic photoelectric devices with semitransparent surface electrodes are combined with a liquid or other suitable vehicle. Together they are injected into the subretinal space of the eye. The microscopic photoelectric devices transduce incident light into electric current that will stimulate the overlying cellular layers of the retina. In persons suffering from visual disfunction due to outer retinal layer damage, such devices may allow useful formed artificial vision. The preferred independent surface electrode microphotodiodes (ISEMCP's) may be in the shape of microspheres, microdiscs or other microshapes. The ISEMCP's are formed of either PiN or NiP type semiconductors, or a combination of both, in a single unit. These devices will form a dipole when exposed to light due to the electric current generated. A magnetic field applied in the vicinity of the eye may help align the ISEMCP's within the retina so that their photo-active surfaces face the incident light. Alternatively, the ISEMCP's may be embedded and prealigned in a transparent flexible sheet, permeable to nutrients and oxygen, before implantation into the subretinal space. Such sheet will allow passage of biological nutrients and oxygen around the ISEMCP's. This sheet may also dissolve leaving behind ISEMCP units lying separately, or in an arranged pattern produced by a surrounding mesh.

摘要翻译： 具有半透明表面电极的显微光电装置与液体或其它合适的载体组合。 一起将它们注入眼睛的视网膜下腔。 微观光电器件将入射光转换成电流，其将刺激视网膜的上层细胞层。 由于外部视网膜层损伤导致视觉障碍的人，这种装置可能允许有用的形成的人造视觉。 优选的独立表面电极微光二极管（ISEMCP）可以是微球，微型盘或其他微形状的形状。 ISEMCP由PiN或NiP型半导体或两者的组合组成，在单个单元中。 当由于产生的电流而暴露于光时，这些器件将形成偶极子。 施加在眼睛附近的磁场可以帮助对准视网膜内的ISEMCP，使得它们的光活性表面面对入射光。 或者，ISEMCP可以在植入视网膜内空间之前嵌入并预先对准在透明柔性片材中，其可渗透营养物质和氧气。 这样的片材将允许ISEMCP周围的生物营养物质和氧气通过。 该片也可以溶解，留下ISEMCP单元分开放置，或以围绕网格产生的排列图案。

公开(公告)号：US5258858A

公开(公告)日：1993-11-02

申请号：US517109

申请日：1990-04-30

申请人： Vincent Chow

发明人： Vincent Chow

IPC分类号： H04N1/19 ,  H04N1/03 ,  H04N1/04

CPC分类号： H04N1/02835 ,  H04N1/03 ,  H04N1/1936 ,  H04N2201/02487

摘要： An optical scanner is disclosed that includes light transmitting and receiving optical fibers to illuminate and scan an image to be copied, transmitted or stored.

摘要翻译： 公开了一种光扫描器，其包括光发射和接收光纤以照亮和扫描要复制，发送或存储的图像。