公开(公告)号：US20100137326A1

公开(公告)日：2010-06-03

申请号：US12706814

申请日：2010-02-17

申请人： Alan K. Mallams ,  Vincent Madison ,  Kamil Paruch

发明人： Alan K. Mallams ,  Vincent Madison ,  Kamil Paruch

IPC分类号： A61K31/4985 ,  C07D471/04 ,  C07D487/04 ,  C07D401/12 ,  C07D401/14 ,  A61K31/444 ,  A61K31/519 ,  A61K31/4439 ,  A61P35/00

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridine and imidazo[1,5-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：US20070054925A1

公开(公告)日：2007-03-08

申请号：US11396079

申请日：2006-03-31

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhen He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhen He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/495

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：US20070054906A1

公开(公告)日：2007-03-08

申请号：US11396001

申请日：2006-03-31

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhen He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhen He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs

IPC分类号： A61K31/5377 ,  A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US07514442B2

公开(公告)日：2009-04-07

申请号：US11395676

申请日：2006-03-31

申请人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Carmen S. Alvarez ,  Tin Yau Chan ,  Chad Knutson ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Carmen S. Alvarez ,  Tin Yau Chan ,  Chad Knutson ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P35/04

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US20070037824A1

公开(公告)日：2007-02-15

申请号：US10654546

申请日：2003-09-03

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhen He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhen He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：US07119200B2

公开(公告)日：2006-10-10

申请号：US10776988

申请日：2004-02-11

申请人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Hobbs ,  Douglas Walsh Hobbs

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Hobbs ,  Douglas Walsh Hobbs

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/495

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：US20080050384A1

公开(公告)日：2008-02-28

申请号：US11788847

申请日：2007-04-20

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhenmin He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs ,  Paul Kirschmeier ,  Rajat Bannerji

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Ronald Doll ,  Viyyoor Girijavallabhan ,  Alan Mallams ,  Carmen Alvarez ,  Kartik Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry Fischmann ,  Lawrence Dillard ,  Vinh Tran ,  Zhenmin He ,  Ray James ,  Haengsoon Park ,  Vidyadhar Paradkar ,  Douglas Hobbs ,  Paul Kirschmeier ,  Rajat Bannerji

IPC分类号： A61K31/519 ,  A61K31/33 ,  A61K31/4965 ,  A61K31/56 ,  A61K31/675 ,  A61K33/24 ,  A61K38/46 ,  A61P19/02 ,  A61P35/00 ,  A61P43/00 ,  A61P29/00 ,  A61K39/395 ,  A61K33/36 ,  A61K31/7004 ,  A61K31/655 ,  A61K31/535 ,  A61K31/497

CPC分类号： A61K31/33 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/519 ,  A61K31/535 ,  A61K31/555 ,  A61K31/56 ,  A61K31/655 ,  A61K31/675 ,  A61K31/7004 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US20070066621A1

公开(公告)日：2007-03-22

申请号：US11514548

申请日：2006-08-31

申请人： Alan Mallams ,  Vincent Madison ,  Kamil Paruch

发明人： Alan Mallams ,  Vincent Madison ,  Kamil Paruch

IPC分类号： A61K31/519 ,  A61K31/496 ,  C07D487/04 ,  C07D471/02 ,  A61K31/4745

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridine and imidazo[1,5-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新的吡唑并[1,5-a]吡啶，吡唑并[1,5-c]嘧啶和2H-吡唑并[4,5-a]吡啶的4-氰基，4-氨基和4-氨基甲基衍生物， 吲唑化合物和咪唑并[1,2-a]吡啶和咪唑并[1,5-a]吡嗪化合物的5-氰基，5-氨基和5-氨基甲基衍生物作为细胞周期蛋白依赖性激酶的抑制剂，制备这些化合物的方法， 含有一种或多种这样的化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US07161003B1

公开(公告)日：2007-01-09

申请号：US10654546

申请日：2003-09-03

申请人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Paradkar ,  Douglas Walsh Hobbs

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Paradkar ,  Douglas Walsh Hobbs

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US07807683B2

公开(公告)日：2010-10-05

申请号：US11396001

申请日：2006-03-31

申请人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Paradkar ,  Douglas Walsh Hobbs

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Paradkar ,  Douglas Walsh Hobbs

IPC分类号： A61K31/519 ,  A61P35/04 ,  A61P35/02 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。