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1.发明申请公开(公告)号：US20050011239A1
公开(公告)日：2005-01-20
申请号：US10858987
申请日：2004-06-01
申请人： Alan Lurie , Joseph Thomas , William Bullwinkel
发明人： Alan Lurie , Joseph Thomas , William Bullwinkel
CPC分类号： E05B17/04 , E05B9/086 , E05B13/105 , E05B63/0056 , E05B65/0864 , E05C5/02 , Y10T70/5195 , Y10T70/7576 , Y10T70/765 , Y10T70/7661
摘要： A convertible mortise/rim cylinder lock assembly having a removable core is disclosed. The lock assembly includes a housing having a longitudinal bore, a removable core dimensioned to be received within the longitudinal bore, a drive member and an actuator. The lock assembly includes a drive member retainer assembly which rotatably secures the drive member within the longitudinal bore of the lock assembly housing. The removable core is removable from the housing independently of the drive member. A core retainer member is provided on the removable core to prevent removal of the core from the lock housing when the removable core is in a locked position. The lock assembly may include a kit having mortise and rim cylinder actuator configurations. The selected actuator may be secured to the drive member to selectively adapt the lock assembly for use as a mortise or a rim cylinder lock assembly.
摘要翻译： 公开了一种具有可移除芯的可转换的榫眼/轮辋缸锁组件。 锁组件包括具有纵向孔的壳体，尺寸适于容纳在纵向孔内的可移除的芯，驱动构件和致动器。 锁组件包括驱动构件保持器组件，其将驱动构件可旋转地固定在锁组件壳体的纵向孔内。 可拆卸的芯部可独立于驱动构件从壳体移除。 芯部保持构件设置在可移除芯上，以防止当可移除芯处于锁定位置时将芯从锁壳移除。 锁组件可以包括具有榫眼和轮辋缸致动器配置的套件。 所选择的致动器可以固定到驱动构件以选择性地适配锁组件以用作榫眼或轮辋缸锁组件。
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公开(公告)号：US20050011237A1
公开(公告)日：2005-01-20
申请号：US10859386
申请日：2004-06-01
申请人： Alan Lurie , Joseph Thomas , William Bullwinkel
发明人： Alan Lurie , Joseph Thomas , William Bullwinkel
CPC分类号： E05B17/04 , E05B9/086 , E05B13/105 , E05B63/0056 , E05B65/0864 , E05C5/02 , Y10T70/5195 , Y10T70/7576 , Y10T70/765 , Y10T70/7661
摘要： A plunger lock assembly having a removable core is provided. The lock assembly includes a housing defining a first longitudinal bore and a barrel reciprocably mounted within the first longitudinal bore between an advanced position and a retracted position. The barrel defines a second longitudinal bore and is operably associated with a plunger. A core is removable mounted within the second longitudinal bore of the barrel and includes a key slot for receiving an operating key. A drive member is positioned within the second longitudinal bore and is movable from an unlocked position to a locked position by operation of the operating key. A retainer assembly is operably associated with the drive member to axially retain the drive member within the second longitudinal bore such that the core is removable from the second longitudinal bore independently of the drive member. A biasing member is provided for urging the barrel towards the retracted position.
摘要翻译： 提供了具有可移除芯的柱塞锁组件。 锁定组件包括限定第一纵向孔的壳体和在先进位置和缩回位置之间可往复运动地安装在第一纵向孔内的桶。 筒体限定第二纵向孔并与柱塞可操作地相关联。 芯可拆卸地安装在筒的第二纵向孔内，并且包括用于接收操作钥匙的钥匙槽。 驱动构件定位在第二纵向孔内并且可以通过操作钥匙从解锁位置移动到锁定位置。 保持器组件与驱动构件可操作地相关联，以将驱动构件轴向保持在第二纵向孔内，使得芯可以独立于驱动构件从第二纵向孔移除。 偏置构件被设置用于朝着缩回位置推动镜筒。
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公开(公告)号：US09023661B2
公开(公告)日：2015-05-05
申请号：US12250953
申请日：2008-10-14
申请人： Joseph Thomas , Michael T. Cash
发明人： Joseph Thomas , Michael T. Cash
IPC分类号： G01N33/533 , G01N33/53 , G01N33/542 , G01N33/66 , G01N33/92
CPC分类号： G01N33/542 , G01N33/66 , G01N33/92
摘要： A method for determining the presence or amount of one or more ligands or analytes in a sample including contacting the sample with a biosensor having an environmentally-sensitive dye conjugated to a binding member, wherein the biosensor compound exhibits a detectable color change as a result of binding to the ligand or analyte or as a result of a change in concentration of the ligand or analyte in the sample. The presently disclosed biosensors can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples.
摘要翻译： 一种用于确定样品中一种或多种配体或分析物的存在或量的方法，包括使样品与具有与结合成员共轭的环境敏感染料的生物传感器接触，其中生物传感器化合物由于 与配体或分析物结合，或作为样品中配体或分析物的浓度变化的结果。 目前公开的生物传感器可用于检测生物样品中生理重要代谢物如葡萄糖，脂肪酸和乳酸盐的存在或数量。
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公开(公告)号：US08838271B2
公开(公告)日：2014-09-16
申请号：US13390662
申请日：2010-11-29
CPC分类号： G01T7/00
摘要： Systems and methods are provided for localizing a radiation or chemical source utilizing a swarm of robotic devices. According to one example, a robotic device will attempt to localize a source by measuring the concentration of source particles in air, and operating in a Chemotactic state, an Anemotactic state, or a Spiraling state.
摘要翻译： 提供了用于利用一群机器人设备来定位辐射或化学源的系统和方法。 根据一个示例，机器人设备将尝试通过测量空气中的源粒子的浓度来定位源，并且在趋向状态，静止状态或螺旋状态下操作。
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公开(公告)号：US20090311290A1
公开(公告)日：2009-12-17
申请号：US12583219
申请日：2009-08-17
IPC分类号： A61K39/245 , A61P31/22
CPC分类号： A61K9/0034 , A61K9/0031 , A61K9/02 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/541 , C12N2710/16622 , C12N2710/16634
摘要： The invention is directed to a suppository based vaccine delivery system for immunizing against urogenital and anorectally transmitted infectious disease in humans and animals and a method for treating the same. More particularly, this invention is directed to a suppository based vaccine delivery system for the prophylaxis against or treatment of urogenital or anorectal transmitted infectious diseases, such as from viral or microbial pathogens. The suppository based delivery system comprises vaccine and/or vaccine adjuvant(s) comprised of whole or fractionated viral or other microbial pathogens, or their purified cellular constituents, whether native, mutated, synthetic, cloned or recombinantly expressed, that consists of nucleic acids, proteins, lipids or other antigenic determinants capable of producing humoral or cellular-mediated immunity in humans or animals; and a polyethylene glycol base; wherein the suppository is adapted to be inserted into a bodily orifice of a human or animal so as to allow the suppository to be in contact with tissue of the bodily orifice to facilitate transfer of vaccine or vaccine adjuvant(s) material therethrough.
摘要翻译： 本发明涉及一种用于在人类和动物中免疫泌尿生殖和肛门直肠传播的传染病的基于栓剂的疫苗递送系统及其治疗方法。 更具体地，本发明涉及一种基于栓剂的疫苗递送系统，用于预防或治疗泌尿生殖或肛门直肠传播的传染病，例如病毒或微生物病原体。 基于栓剂的递送系统包括由全部或分馏的病毒或其他微生物病原体组成的疫苗和/或疫苗佐剂，或其纯化的细胞成分，无论是天然的，突变的，合成的，克隆的或重组表达的，由核酸组成， 能够在人或动物中产生体液或细胞介导的免疫的蛋白质，脂质或其它抗原决定簇; 和聚乙二醇碱; 其中栓剂适于插入人或动物的身体孔中，以便使栓剂与身体孔的组织接触以促进疫苗或疫苗佐剂材料通过其传送。
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公开(公告)号：US06735991B2
公开(公告)日：2004-05-18
申请号：US10194045
申请日：2002-07-10
申请人： Alan E. Lurie , Joseph Thomas
发明人： Alan E. Lurie , Joseph Thomas
IPC分类号： E05B6544
CPC分类号： E05B17/2088 , E05B15/0205 , E05B15/10 , Y10T70/5097 , Y10T70/5102 , Y10T70/5327
摘要： A tamper resistant lock assembly is disclosed which is configured to prevent keyless operation of the lock assembly. The tamper resistant lock assembly includes a lock housing having a bolt slidably supported therein and a strike. The lock housing is secured to a mounting plate which is adapted to be fastened to a movable member such as a door. The strike is adapted to be fastened to a support member such as a door jam at a position to facilitate engagement between the bolt and the strike when the movable member is in a closed position. The strike includes a C-shaped catch member defining a recess having an opening which is configured to receive an engagement portion of the strike when the movable member is in the closed position. The engagement portion of the strike is also C-shaped and defines a recess. When the engagement portion of the presently disclosed strike is engaged by the catch member of the presently disclosed bolt, a lip portion of the bolt is positioned within the recess of the engagement portion of the strike and a lip portion of the strike is positioned within the recess of the catch member of the strike to provide an interlocking engagement which resists tampering.
摘要翻译： 公开了防拆锁组件，其被配置为防止锁组件的无钥匙操作。 防拆锁组件包括具有可滑动地支撑在其中的螺栓和撞击的锁壳体。 锁定壳体固定到适于紧固到诸如门的可移动构件的安装板。 撞击适于在可移动部件处于关闭位置时被固定到支撑部件，例如门卡在位置以便于螺栓和打击之间的接合。 撞击包括限定具有开口的凹部的C形卡扣构件，该开口构造成当可动构件处于关闭位置时容纳撞击的接合部分。 撞击的接合部分也是C形并且限定凹部。 当目前公开的冲击的接合部分被当前公开的螺栓的卡扣构件接合时，螺栓的唇部位于撞击的接合部分的凹部内，并且撞击的唇部位于 罢工构件的凹部以提供抵抗篡改的互锁接合。
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公开(公告)号：US08962342B2
公开(公告)日：2015-02-24
申请号：US12134594
申请日：2008-06-06
IPC分类号： G01N21/65 , G01N33/58 , A61K49/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C09B23/10 , C09B63/00
CPC分类号： G01N21/658 , A61K49/0021 , A61K49/0065 , A61K49/0093 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07D265/36 , C07D405/06 , C07D417/06 , C09B23/105 , C09B63/00 , G01N33/587 , G01N2201/06113 , Y10T428/2982 , Y10T436/24
摘要： Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is selected from the group consisting of: wherein X1 is CR4 or N; and Y is selected from the group consisting of:
摘要翻译： 公开了包含式A-Y的表面增强拉曼散射（SERS）报道分子及其使用方法的纳米颗粒，其中A选自：其中X 1是CR 4或N; Y选自：
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公开(公告)号：US07765991B2
公开(公告)日：2010-08-03
申请号：US11463489
申请日：2006-08-09
申请人： Joseph Thomas , James Kerns
发明人： Joseph Thomas , James Kerns
IPC分类号： F02M33/02
CPC分类号： F02D41/3845 , F02D41/0032 , F02D41/1454 , F02D41/222 , F02D41/2448 , F02D41/2451 , F02D2250/31 , F02M25/089
摘要： A method of controlling an internal combustion engine having a fuel vapor purging system and a fuel delivery system including a fuel pump and a fuel pressure sensor for detecting the fuel pressure provided by the fuel pump is disclosed. In one example, the method includes, during a degraded condition of the fuel pressure sensor, adjusting the fuel pump output in response to an operating condition, adjusting at least one of a condition of the fuel vapor purging system and adaptive learning of a characteristic of the fuel delivery system; and further adjusting the fuel pump output in response to an output of an exhaust gas sensor while also adjusting an amount of fuel injected into a cylinder of the engine in response to said output of the exhaust gas sensor.
摘要翻译： 公开了一种控制具有燃料蒸气净化系统的内燃机和包括用于检测燃料泵所提供的燃料压力的燃料泵和燃料压力传感器的燃料输送系统的方法。 在一个示例中，该方法包括在燃料压力传感器的劣化状态期间响应于操作条件调节燃料泵输出，调节燃料蒸气净化系统的状态和自适应学习中的至少一个 燃油输送系统; 并且响应于排气传感器的输出而进一步调节燃料泵输出，同时响应于所述废气传感器的输出来调节喷射到发动机的气缸中的燃料量。
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9.发明申请公开(公告)号：US20080311675A1
公开(公告)日：2008-12-18
申请号：US12124553
申请日：2008-05-21
申请人： Joseph Thomas , Michael T. Cash
发明人： Joseph Thomas , Michael T. Cash
IPC分类号： G01N33/566 , C07D405/06 , C07K14/00 , C07K16/00
CPC分类号： G01N33/582 , A61K8/498 , C09B23/105 , C09B57/02 , C12M1/34 , G01N33/53 , G01N33/533 , G01N33/66
摘要： The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When conjugated with a binding protein, the fluorophores exhibit a ratiometric response to one or more ligands or target analytes. The presently disclosed fluorophore-binding protein conjugates can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples.
摘要翻译： 目前公开的主题提供在可见光谱区域中具有发射波长的硫醇反应性，环境敏感的荧光染料或荧光团。 当与结合蛋白结合时，荧光团对一种或多种配体或靶分析物显示出比例的响应。 目前公开的荧光团结合蛋白结合物可用于检测生物样品中生理重要代谢物如葡萄糖，脂肪酸和乳酸盐的存在或数量。
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公开(公告)号：US20060016174A1
公开(公告)日：2006-01-26
申请号：US10898641
申请日：2004-07-23
IPC分类号： F01N3/00
CPC分类号： F01N3/0842 , F01N3/0871 , Y02A50/2325
摘要： An improved engine control system using a NOx sensor is disclosed. In one example, the NOx sensor structure and/or signals are modified to improve distance transmission of NOx sensor output signals so that at least some processing electronics can be relocated remote to the sensor and in an engine control unit, or other such control unit utilizing the NOx sensor signals, and controlling the NOx sensor heaters, if applicable.
摘要翻译： 公开了一种改进的使用NOx传感器的发动机控制系统。 在一个示例中，NOx传感器结构和/或信号被修改以改善NOx传感器输出信号的距离传输，使得至少一些处理电子装置可以远程地重新定位到传感器和发动机控制单元或其他这样的控制单元中，利用 NOx传感器信号，并且如果适用，则控制NOx传感器加热器。
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