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公开(公告)号:US08822446B2
公开(公告)日:2014-09-02
申请号:US13086546
申请日:2011-04-14
IPC分类号: A61K31/40 , A61K31/505 , A61K31/54 , A61K31/535 , A61K31/44 , C07D239/02 , C07D279/10 , C07D413/04 , C07D471/02
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R1a,R1b,R1c,X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号:US08383624B2
公开(公告)日:2013-02-26
申请号:US12836637
申请日:2010-07-15
申请人: Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
发明人: Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
IPC分类号: A61K31/495
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R1a,R1b,X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号:US20120220572A1
公开(公告)日:2012-08-30
申请号:US13406937
申请日:2012-02-28
IPC分类号: A61K31/519 , A61K31/5377 , A61K31/538 , A61P35/00 , A61K31/55 , C07D471/04 , C07D513/04 , A61K31/541 , C07D487/14 , A61K31/551
CPC分类号: C07D487/14
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中X,Y,Z,R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号:US08710065B2
公开(公告)日:2014-04-29
申请号:US13406937
申请日:2012-02-28
IPC分类号: A61K31/505 , C07D491/00
CPC分类号: C07D487/14
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中X,Y,Z,R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号:US08435980B2
公开(公告)日:2013-05-07
申请号:US12836753
申请日:2010-07-15
申请人: Alan S. Florjancic , Yunsong Tong , Thomas D. Penning , Jane Gong , Magdalena Przytulinska , Douglas Steinman , James Holms , Chunqiu Lai , Gui-Dong Zhu , Keith Woods
发明人: Alan S. Florjancic , Yunsong Tong , Thomas D. Penning , Jane Gong , Magdalena Przytulinska , Douglas Steinman , James Holms , Chunqiu Lai , Gui-Dong Zhu , Keith Woods
IPC分类号: C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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公开(公告)号:US20110257152A1
公开(公告)日:2011-10-20
申请号:US13086546
申请日:2011-04-14
IPC分类号: A61K31/444 , A61P35/00 , A61K31/541 , A61K31/5377 , C07D471/04 , A61K31/513
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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公开(公告)号:US20110015173A1
公开(公告)日:2011-01-20
申请号:US12836753
申请日:2010-07-15
IPC分类号: A61K31/397 , C07D471/04 , A61K31/437 , A61K31/506 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R1a,R1b,R1c,X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号:US20110015172A1
公开(公告)日:2011-01-20
申请号:US12836637
申请日:2010-07-15
申请人: Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
发明人: Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
IPC分类号: A61K31/4985 , C07D471/04 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R1a,R1b,X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号:US06998390B2
公开(公告)日:2006-02-14
申请号:US10420390
申请日:2003-04-22
申请人: Zhenkun Ma , Stevan Djuric , Alan S. Florjancic , Hong Yong
发明人: Zhenkun Ma , Stevan Djuric , Alan S. Florjancic , Hong Yong
CPC分类号: C07H17/08
摘要: Antibacterial compounds having formula (I) and formula (II) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.
摘要翻译: 具有式(I)的化合物<化学id =“CHEM-US-00001”num =“000
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公开(公告)号:US08841334B2
公开(公告)日:2014-09-23
申请号:US12274105
申请日:2008-11-19
申请人: Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson , Xueqing Wang
发明人: Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson , Xueqing Wang
IPC分类号: A61K31/426 , C07D277/08
CPC分类号: C07D277/46 , C07D277/28 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/08
摘要: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译: 本发明涉及式(I)化合物或其药物盐,前体药物,前体药物或其组合的盐,其中R1,R2,R3,R4和L1在说明书中定义,包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式(II)化合物或其药物盐,前药,前体药物或其组合的盐,其中R 1a,R 2a,R x和n如说明书中所定义,包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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