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公开(公告)号：US08435980B2
公开(公告)日：2013-05-07
申请号：US12836753
申请日：2010-07-15
申请人： Alan S. Florjancic , Yunsong Tong , Thomas D. Penning , Jane Gong , Magdalena Przytulinska , Douglas Steinman , James Holms , Chunqiu Lai , Gui-Dong Zhu , Keith Woods
发明人： Alan S. Florjancic , Yunsong Tong , Thomas D. Penning , Jane Gong , Magdalena Przytulinska , Douglas Steinman , James Holms , Chunqiu Lai , Gui-Dong Zhu , Keith Woods
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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公开(公告)号：US08383624B2
公开(公告)日：2013-02-26
申请号：US12836637
申请日：2010-07-15
申请人： Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
发明人： Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US20110015172A1
公开(公告)日：2011-01-20
申请号：US12836637
申请日：2010-07-15
申请人： Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
发明人： Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
IPC分类号： A61K31/4985 , C07D471/04 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US08822446B2
公开(公告)日：2014-09-02
申请号：US13086546
申请日：2011-04-14
IPC分类号： A61K31/40 , A61K31/505 , A61K31/54 , A61K31/535 , A61K31/44 , C07D239/02 , C07D279/10 , C07D413/04 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US20110257152A1
公开(公告)日：2011-10-20
申请号：US13086546
申请日：2011-04-14
IPC分类号： A61K31/444 , A61P35/00 , A61K31/541 , A61K31/5377 , C07D471/04 , A61K31/513
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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![PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES](/abs-image/US/2013/01/24/US20130023523A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130023523A1
公开(公告)日：2013-01-24
申请号：US13552876
申请日：2012-07-19
申请人： Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqiu Lai , Keith W. Woods
发明人： Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqiu Lai , Keith W. Woods
IPC分类号： C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US07956185B2
公开(公告)日：2011-06-07
申请号：US11753279
申请日：2007-05-24
申请人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
发明人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
IPC分类号： C07D239/02
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
摘要翻译： 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。
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公开(公告)号：US08710065B2
公开(公告)日：2014-04-29
申请号：US13406937
申请日：2012-02-28
IPC分类号： A61K31/505 , C07D491/00
CPC分类号： C07D487/14
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中X，Y，Z，R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US20120220572A1
公开(公告)日：2012-08-30
申请号：US13406937
申请日：2012-02-28
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/538 , A61P35/00 , A61K31/55 , C07D471/04 , C07D513/04 , A61K31/541 , C07D487/14 , A61K31/551
CPC分类号： C07D487/14
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中X，Y，Z，R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US20110015173A1
公开(公告)日：2011-01-20
申请号：US12836753
申请日：2010-07-15
IPC分类号： A61K31/397 , C07D471/04 , A61K31/437 , A61K31/506 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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