-
公开(公告)号：US20120220572A1
公开(公告)日：2012-08-30
申请号：US13406937
申请日：2012-02-28
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/538 , A61P35/00 , A61K31/55 , C07D471/04 , C07D513/04 , A61K31/541 , C07D487/14 , A61K31/551
CPC分类号： C07D487/14
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中X，Y，Z，R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
-
公开(公告)号：US08710065B2
公开(公告)日：2014-04-29
申请号：US13406937
申请日：2012-02-28
IPC分类号： A61K31/505 , C07D491/00
CPC分类号： C07D487/14
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X, Y, Z, R3 and R4 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中X，Y，Z，R 3和R 4在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
-
公开(公告)号：US20080015192A1
公开(公告)日：2008-01-17
申请号：US11753279
申请日：2007-05-24
申请人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
发明人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
IPC分类号： A61K31/50 , A61K31/34 , A61K31/40 , A61K31/505 , A61P35/00 , C07D233/61 , C07D239/24 , C07D307/04 , C07D413/02 , C07D277/08 , C07D239/20 , C07D207/30 , A61K31/5377 , A61K31/4164 , A61K31/425
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译： 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。
-
![6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists](/abs-image/US/2011/08/09/US07994163B2/abs.jpg.150x150.jpg)
4.发明授权6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists 有权6-取代-2,3,4,5-四氢-1H-苯并[d]吖庚因，为5-HT 2C受体激动剂公开(公告)号：US07994163B2
公开(公告)日：2011-08-09
申请号：US11996457
申请日：2006-09-01
申请人： John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
发明人： John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
IPC分类号： A61P3/04 , A61P25/00 , A61P25/22 , A61P25/24 , A61K31/55 , C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
CPC分类号： C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R?N—R″R* where R6 is —(CrC3)alkyl-S—(C0-C3)alkyl-R10, —(C1-C3)alkyl-NR11R12, —(CrC3)alkyl-O—R13. and other substituents are as defined in the specification.
摘要翻译： 本发明提供式（I）的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性的5-HT 2C受体激动剂，用于治疗5-HT2c相关疾病，包括肥胖，强迫症/ 强迫症，抑郁症和焦虑症：R6 DR？N-R“R *其中R6是 - （CrC3）烷基-S-（C0-C3）烷基-R10， - （C1-C3）烷基-NR11R12 - （CrC3 ）烷基-O-R13。 和其它取代基如说明书中所定义。
-
公开(公告)号：US20050131050A1
公开(公告)日：2005-06-16
申请号：US11048037
申请日：2005-01-31
申请人： John Talley , Thomas Penning , Paul Collins , Donald Rogier , James Malecha , Julie Miyashiro , Stephen Bertenshaw , Ish Khanna , Matthew Graneto , Roland Rogers , Jeffery Carter , Stephen Docter , Stella Yu
发明人： John Talley , Thomas Penning , Paul Collins , Donald Rogier , James Malecha , Julie Miyashiro , Stephen Bertenshaw , Ish Khanna , Matthew Graneto , Roland Rogers , Jeffery Carter , Stephen Docter , Stella Yu
IPC分类号： C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K31/416 , A61K31/4152 , C07D231/10 , C07D45/02
CPC分类号： C07D409/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycaronyl, cyano, cyanoalkyl, carboxyl, aminocaronyl, alkylaminocarbonyl, cycloalklaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, amioncarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not arakenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.
-
![6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists](/abs-image/US/2008/10/16/US20080255092A1/abs.jpg.150x150.jpg)
6.发明申请6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists 有权6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂卓作为5-Ht2c受体激动剂公开(公告)号：US20080255092A1
公开(公告)日：2008-10-16
申请号：US11996457
申请日：2006-09-01
申请人： John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
发明人： John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R?N—R″R* where R6 is —(CrC3)alkyl-S—(C0-C3)alkyl-R10, —(C1-C3)alkyl-NR11R12, —(CrC3)alkyl-O—R13. and other substituents are as defined in the specification.
摘要翻译： 本发明提供式（I）的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性的5-HT 2C受体激动剂，用于治疗5-HT2c相关疾病，包括肥胖，强迫症/ 强迫症，抑郁症和焦虑症：R6 DR？N-R''R *其中R6是 - （CrC3）烷基-S-（C0-C3）烷基-R10， - （C1-C3）烷基-NR11R12 - （ C 1 -C 3烷基-O-R 13。 和其它取代基如说明书中所定义。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.031 秒)
