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公开(公告)号：US20110028395A1
公开(公告)日：2011-02-03
申请号：US12522042
申请日：2008-01-03
IPC分类号： A61K38/08 , C07K7/06 , C07K7/08 , A61K38/10 , C07H21/00 , C12N15/63 , C12N5/071 , A61K31/7088 , A61P35/00
CPC分类号： C07K14/57518 , A61K38/00 , C07K14/00
摘要： The invention generally features compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators. As described in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
摘要翻译： 本发明通常具有可用于调节血管形成的组合物和方法，以及提供血管新生调节剂的系统和有效鉴定的方法。 如下文更详细地描述的，使用基于生物信息学的系统计算方法来鉴定已在体外和/或体内表征的新型血管生成肽调节剂。
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公开(公告)号：US08507434B2
公开(公告)日：2013-08-13
申请号：US12522042
申请日：2008-01-03
CPC分类号： C07K14/57518 , A61K38/00 , C07K14/00
摘要： Compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators are described. As discussed in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
摘要翻译： 描述了可用于调节血管形成的组合物和方法，以及提供系统和有效鉴定血管生成调节剂的方法。 如下面更详细地讨论的，使用基于生物信息学的系统计算方法来鉴定已经在体外和/或体内表征的新型血管生成肽调节剂。
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公开(公告)号：US08557772B2
公开(公告)日：2013-10-15
申请号：US13369240
申请日：2012-02-08
CPC分类号： C07K14/47 , C07K14/472 , C07K14/475 , C07K14/78 , C12N9/6421 , C12N9/6489
摘要： Compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators are described. As discussed in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
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公开(公告)号：US20120232012A1
公开(公告)日：2012-09-13
申请号：US13369240
申请日：2012-02-08
IPC分类号： A61K38/10 , A61K48/00 , A61P9/00 , C07K7/08 , C07K14/47 , C07K14/52 , C07K7/06 , C12N15/63 , C12N5/071 , C12N1/22 , C12N5/10 , C12N1/19 , C12N15/85 , A61K38/08 , A61K38/17 , A61K38/19 , C12N15/12
CPC分类号： C07K14/47 , C07K14/472 , C07K14/475 , C07K14/78 , C12N9/6421 , C12N9/6489
摘要： The invention generally features compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators. As described in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
摘要翻译： 本发明通常具有可用于调节血管形成的组合物和方法，以及提供血管新生调节剂的系统和有效鉴定的方法。 如下文更详细地描述的，使用基于生物信息学的系统计算方法来鉴定已在体外和/或体内表征的新型血管生成肽调节剂。
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公开(公告)号：US20100144641A1
公开(公告)日：2010-06-10
申请号：US11992001
申请日：2006-09-12
IPC分类号： A61K38/16 , C07K7/06 , C07K7/08 , C12N15/74 , C12N1/00 , A61K38/08 , A61K38/10 , C07K1/00 , A61P35/00
CPC分类号： C07K14/47 , C07K14/472 , C07K14/475 , C07K14/78 , C12N9/6421 , C12N9/6489
摘要： The invention generally features compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of angiogenesis modulators. As described in more detail below, a systematic computational methodology based on bioinformatics was used to identify novel peptide modulators of angiogenesis that have been characterized in vitro and/or in vivo.
摘要翻译： 本发明通常具有可用于调节血管形成的组合物和方法，以及提供血管新生调节剂的系统和有效鉴定的方法。 如下文更详细地描述的，使用基于生物信息学的系统计算方法来鉴定已在体外和/或体内表征的新型血管生成肽调节剂。
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公开(公告)号：US09717694B2
公开(公告)日：2017-08-01
申请号：US13272042
申请日：2011-10-12
申请人： Jordan Jamieson Green , Aleksander S. Popel , Joel Chaim Sunshine , Ron B. Shmueli , Stephany Yi Tzeng , Kristen Lynn Kozielski
发明人： Jordan Jamieson Green , Aleksander S. Popel , Joel Chaim Sunshine , Ron B. Shmueli , Stephany Yi Tzeng , Kristen Lynn Kozielski
IPC分类号： A61K9/50 , A61K38/39 , A61K9/00 , A61K9/06 , A61K9/19 , A61K9/51 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/34 , B82Y5/00 , C12N15/88 , C12N15/11
CPC分类号： A61K9/5026 , A61K9/0019 , A61K9/06 , A61K9/19 , A61K9/5146 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/39 , A61K47/34 , B82Y5/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10T428/2982
摘要： Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
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7.发明申请MIMETIC PEPTIDES DERIVED FROM COLLAGEN TYPE IV AND THEIR USE FOR TREATING ANGIOGENESIS- AND LYMPHAGIOGENESIS-DEPENDENT DISEASES 审中-公开从胶原IV型衍生的胶体蛋白及其用于治疗血管发生和淋巴细胞生成的疾病公开(公告)号：US20130316950A1
公开(公告)日：2013-11-28
申请号：US13992998
申请日：2011-12-12
申请人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
发明人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
IPC分类号： C07K14/78
摘要： Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.
摘要翻译： 公开了具有抗血管生成和抗肿瘤发生特性的模拟肽及其用于治疗癌症，眼部疾病如年龄相关性黄斑变性和其它血管发生依赖性疾病的方法。 更具体地，在内皮细胞增殖，迁移，粘附和管形成测定中表现出抗血管生成活性的活性非半胱氨酸类似物（模拟物），体外人乳腺癌细胞中的抗迁移活性，抗血管生成和抗 - 公开了乳腺癌异种移植模型体内的致瘤活性和年龄相关性黄斑变性模型。 目前公开的模拟肽还表现出抗淋巴管生成和直接抗致瘤性质。
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公开(公告)号：US20120114759A1
公开(公告)日：2012-05-10
申请号：US13272042
申请日：2011-10-12
申请人： Jordan Jamieson Green , Aleksander S. Popel , Joel Chaim Sunshine , Ron B. Shmueli , Stephany Yi Tzeng , Kristen Lynn Kozielski
发明人： Jordan Jamieson Green , Aleksander S. Popel , Joel Chaim Sunshine , Ron B. Shmueli , Stephany Yi Tzeng , Kristen Lynn Kozielski
IPC分类号： A61K9/14 , A61K31/713 , A61K48/00 , A61K31/7105 , A61K31/711 , A61K47/34 , A61P35/00 , A61K38/10 , A61K38/08 , A61K38/20 , A61K38/39 , C12N5/071 , C12N15/85 , A61P27/02 , C08G75/00 , C08L5/00 , A61K38/02 , B82Y30/00
CPC分类号： A61K9/5026 , A61K9/0019 , A61K9/06 , A61K9/19 , A61K9/5146 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/39 , A61K47/34 , B82Y5/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10T428/2982
摘要： Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
摘要翻译： 用于将物质（例如治疗剂，例如肽）递送至靶标例如细胞的聚合物纳米颗粒，微粒和凝胶及其用于治疗疾病的用途，包括血管发生依赖性疾病，例如年龄相关性黄斑 变性和癌症。 公开了通过聚合物颗粒和凝胶递送系统配制，稳定和施用单一肽或肽组合的方法。
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公开(公告)号：US20160374949A9
公开(公告)日：2016-12-29
申请号：US13272042
申请日：2011-10-12
申请人： Jordan Jamieson Green , Aleksander S. Popel , Joel Chaim Sunshine , Ron B. Shmueli , Stephany Yi Tzeng , Kristen Lynn Kozielski
发明人： Jordan Jamieson Green , Aleksander S. Popel , Joel Chaim Sunshine , Ron B. Shmueli , Stephany Yi Tzeng , Kristen Lynn Kozielski
IPC分类号： A61K9/14 , A61K31/713 , A61K48/00 , A61K31/7105 , A61K31/711 , A61K47/34 , A61P35/00 , A61K38/10 , A61K38/08 , A61K38/20 , A61K38/39 , C12N5/071 , C12N15/85 , A61P27/02 , C08G75/00 , C08L5/00 , A61K38/02 , B82Y30/00
CPC分类号： A61K9/5026 , A61K9/0019 , A61K9/06 , A61K9/19 , A61K9/5146 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/39 , A61K47/34 , B82Y5/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , Y10T428/2982
摘要： Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
摘要翻译： 用于将物质（例如治疗剂，例如肽）递送至靶标例如细胞的聚合物纳米颗粒，微粒和凝胶及其用于治疗疾病的用途，包括血管发生依赖性疾病，例如年龄相关性黄斑 变性和癌症。 公开了通过聚合物颗粒和凝胶递送系统配制，稳定和施用单一肽或肽组合的方法。
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10.发明授权Mimetic peptides derived from collagen type IV and their use for treating angiogenesis- and lymphagiogenesis-dependent diseases 有权衍生自IV型胶原的模拟肽及其用于治疗血管生成和淋巴管生成依赖性疾病的用途公开(公告)号：US09056923B2
公开(公告)日：2015-06-16
申请号：US13992998
申请日：2011-12-12
申请人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
发明人： Aleksander S. Popel , Elena V. Rosca , Jacob E. Koskimaki , Corban G. Rivera , Niranjan B. Pandey , Amir P. Tamiz
摘要： Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties.
摘要翻译： 公开了具有抗血管生成和抗肿瘤发生特性的模拟肽及其用于治疗癌症，眼部疾病如年龄相关性黄斑变性和其它血管发生依赖性疾病的方法。 更具体地，在内皮细胞增殖，迁移，粘附和管形成测定中表现出抗血管生成活性的活性非半胱氨酸类似物（模拟物），体外人乳腺癌细胞中的抗迁移活性，抗血管生成和抗 - 公开了乳腺癌异种移植模型体内的致瘤活性和年龄相关性黄斑变性模型。 目前公开的模拟肽还表现出抗淋巴管生成和直接抗致瘤性质。
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